scholarly journals Risk alleles for IgA nephropathy-associated SNPs conferred completely opposite effects to idiopathic membranous nephropathy in Chinese Han

2017 ◽  
Vol 65 (5) ◽  
pp. 1059-1064 ◽  
Author(s):  
Xiaosong Qin ◽  
Chen Wang ◽  
Guanting Lu ◽  
Mengle Peng ◽  
Guixue Cheng ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
Idiopathic Membranous Nephropathy ◽  
Chinese Han ◽  
Risk Alleles

scholarly journals MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy

2016 ◽  
Vol 28 (5) ◽  
pp. 1651-1664 ◽  
Author(s):  
Zhao Cui ◽  
Li-jun Xie ◽  
Fang-jin Chen ◽  
Zhi-yong Pei ◽  
Li-jie Zhang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mhc Class Ii ◽  
Membranous Nephropathy ◽  
Class Ii ◽  
Idiopathic Membranous Nephropathy ◽  
Amino Acid Residues ◽  
Risk Alleles

scholarly journals A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy

2020 ◽  
Vol 42 (2) ◽  
pp. 254-258
Author(s):  
David Campos Wanderley ◽  
Bárbara Dornelas Jones ◽  
Fabricio Augusto Marques Barbosa ◽  
Stanley de Almeida Araujo
Keyword(s):  
Nephrotic Syndrome ◽  
Iga Nephropathy ◽  
Male Patient ◽  
Membranous Nephropathy ◽  
Rare Case ◽  
The Other ◽  
Idiopathic Membranous Nephropathy ◽  
Secondary Literature ◽  
Nephrotic Range Proteinuria ◽  
Histopathology Examination

ABSTRACT Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of autoantibodies (PLA2R and THSD7A) directed against podocyte antigens. The detection of antibodies against a domain favors IMN. The presence of autoantibodies against one of the domains would in theory exclude the possibility of there being autoantibodies against the other domain. However, cases of patients with PLA2R- and THSD7A-positive disease have been recently reported, showing that antibodies against two targets may be concomitantly produced via yet unknown pathophysiological mechanisms. This study reports the case of a 46-year-old male patient with nephrotic-range proteinuria, hematuria, hypoalbuminemia, and hypercholesterolemia submitted to biopsy and histopathology examination (LM, IF, IHC, and EM) eventually diagnosed with PLA2R- and THSD7A-positive IMN associated with IgA nephropathy, stressing our experience with the use of IgG subclasses, PLA2R, and THSD7A in the workup for MN and the relevance of adopting a broad and adequate approach to elucidating and acquiring knowledge of the pathophysiology of IMN.

scholarly journals Variants in the Promoter Region of HLA-DQA1 were Associated with Idiopathic Membranous Nephropathy in a Chinese Han Population

2017 ◽  
Vol 130 (14) ◽  
pp. 1677-1682 ◽  
Author(s):  
Xiao-Song Qin ◽  
Jian-Hua Liu ◽  
Guan-Ting Lyu ◽  
Meng-Le Peng ◽  
Fu-Ning Yang ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Promoter Region ◽  
Chinese Han Population ◽  
Idiopathic Membranous Nephropathy ◽  
Chinese Han ◽  
Han Population ◽  
Hla Dqa1

scholarly journals PLA2R1 and HLA-DQA1 gene variations in idiopathic membranous nephropathy in South China

2021 ◽  
Vol 50 (1) ◽  
pp. 33-41
Author(s):  
Fan Wang ◽  
Ting-Ting Wang ◽  
Xiao-Wan Liang ◽  
Jian-Da Lu ◽  
Qiong-Hong Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Serum Albumin ◽  
Membranous Nephropathy ◽  
Spontaneous Remission ◽  
Idiopathic Membranous Nephropathy ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
Chinese Han ◽  
Phospholipase A2 Receptor ◽  
Hla Dqa1

ABSTRACT Introduction: Associations of variations in PLA2R1 and HLA-DQA1 genes with susceptibility to idiopathic membranous nephropathy (IMN) have been well documented. Association with spontaneous remission, however, is poorly defined in the Chinese Han population. Methods: A Chinese cohort of 117 IMN patients and 138 healthy controls were recruited between July 2009 and November 2019. Case-control studies for single-nucleotide polymorphisms (SNPs) within HLA-DQA1 (rs2187668) and PLA2R1 (rs35771982, rs4664308, rs3749117, rs3749119) genes were performed. The contributions of these polymorphisms to predict susceptibility, titre of autoantibodies against the M-type phospholipase A2 receptor (anti-PLA2R1), glomerular PLA2R1 expression, and spontaneous remission were analysed. Results: We found that variations in PLA2R1 (SNPs rs35771982, rs4664308, rs3749117) were strongly associated with IMN susceptibility, while SNP (rs2187668) within HLA-DQA1 did not increase the risk of IMN. All SNPs in PLA2R1 and HLA-DQA1 were not statistically associated with anti-PLA2R1 titre, glomerular PLA2R1 expression and spontaneous remission after Bonferroni correction (P>0.0167). Clinical and pathological parameters such as lower levels of serum albumin, higher levels of anti-PLA2R1 and glomerular PLA2R1 expression were independent risk factors for non-spontaneous remission. Conclusion: This study confirms that variations in PLA2R1 (SNPs rs35771982, rs4664308, rs3749117) are risk factors for IMN. We found excellent association of serum albumin level, anti-PLA2R1 titre and glomerular PLA2R1 positivity with non-spontaneous remission in IMN. Keywords: HLA-DQA1, idiopathic membranous nephropathy, PLA2R1, susceptibility, spontaneous remission

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