scholarly journals Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Yi-Yu Lu ◽  
Yu Zhao ◽  
Ya-Nan Song ◽  
Shu Dong ◽  
Bin Wei ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Serum Cytokine ◽  
Zheng Differentiation ◽  
Profiling Analysis ◽  
Cytokine Profiling

scholarly journals Circulating miR-583 and miR-663 Refer to ZHENG Differentiation in Chronic Hepatitis B

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Hui Zhang ◽  
Yan Guan ◽  
Yi-Yu Lu ◽  
Yi-Yang Hu ◽  
Shuang Huang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Target Genes ◽  
Enrichment Analysis ◽  
Deficiency Syndrome ◽  
Mapk Signaling ◽  
Pathway Enrichment Analysis ◽  
Roc Curve Analysis ◽  
Zheng Differentiation

Traditional Chinese medicine (TCM) ZHENG as the key pathological principle is to understand the human homeostasis and guide TCM treatment. Here, circulating microRNAs (miRNAs) were utilized to differentiate between ZHENGs including liver-gallbladder dampness-heat syndrome (LGDHS) and liver-kidney yin deficiency syndrome (LKYDS) in chronic hepatitis B (CHB). Sera samples of CHB patients with LGDHS (n=35), LKYDS (n=24), and healthy controls (Ctrls,n=21) were analyzed by microarray and real-time RT-PCR. Receiver-operator characteristic (ROC) curves were established to evaluate the levels of serum miRNA for discriminating LGDHS and LKYDS. The target genes of miRNAs were predicted by TargetScan. Gene Ontology (GO) and pathways were analyzed using DAVID tool. The results showed that 22 miRNAs were differentially expressed between LGDHS and LKYDS (fold change>2.0 andP<0.01). Circulating miR-583 and miR-663 were significantly higher (P<0.001) in CHB patients with LGDHS than those with LKYDS and Ctrls. ROC curve analysis revealed that miR-583 and miR-663 were sensitive and specific enough to distinguish LGDHS from LKYDS. Pathway enrichment analysis indicated that 354 putative targets for miR-583 and 68 putative targets for miR-663 were mainly involved in Axon guidance, Neurotrophin, and MAPK signaling pathway. miR-583 and miR-663 may be potential markers for ZHENG differentiation in CHB.

scholarly journals Serum cytokine levels in patients with chronic hepatitis B according to lamivudine therapy

2011 ◽  
Vol 25 (6) ◽  
pp. 414-421 ◽  
Author(s):  
Younhee Park ◽  
Yongjung Park ◽  
Kwang-Hyub Han ◽  
Hyon-Suk Kim
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Serum Cytokine ◽  
Lamivudine Therapy ◽  
Cytokine Levels

Serum cytokine/chemokine profiles in acute exacerbation of chronic hepatitis B: Clinical and mechanistic implications

2014 ◽  
Vol 29 (8) ◽  
pp. 1629-1636 ◽  
Author(s):  
Hui-Lin Wu ◽  
Jia-Horng Kao ◽  
Ting-Chih Chen ◽  
Wen-Hsuan Wu ◽  
Chen-Hua Liu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Acute Exacerbation ◽  
Chronic Hepatitis B ◽  
Serum Cytokine

scholarly journals Differential Serum Cytokine Profiles in Patients with Chronic Hepatitis B, C, and Hepatocellular Carcinoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jacqueline Estevez ◽  
Vincent L. Chen ◽  
Ondrej Podlaha ◽  
Biao Li ◽  
An Le ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Serum Cytokine ◽  
Cytokine Profiles

scholarly journals The association between serum cytokine and chemokine levels and antiviral response by entecavir treatment in chronic hepatitis B patients

2017 ◽  
Vol 23 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Mio Kurihara ◽  
Masataka Tsuge ◽  
Eisuke Murakami ◽  
Nami Mori ◽  
Waka Ohishi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Antiviral Response ◽  
Serum Cytokine
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