Role of steroid priming in the treatment of chronic hepatitis B

2000 ◽  
Vol 15 (5 (Suppl.)) ◽  
pp. E41-E45 ◽  
Author(s):  
Osamu Yokosuka
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B

scholarly journals Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yong Li ◽  
Chuanlong Zhu ◽  
Faxi Wang ◽  
Tiantian Zhu ◽  
Jun Li ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Treatment Response ◽  
Chronic Hepatitis B ◽  
Hepg2 Cells ◽  
Hbv Dna ◽  
Stat Signaling ◽  
Ifn Treatment

Interferon-α (IFN-α) has limited response rate in the treatment of chronic hepatitis B (CHB). The underlying mechanism of differential responsiveness to IFN remains elusive. It has been recently reported that SART1 mediates antiviral effects of IFN-α in the hepatitis C virus (HCV) cell culture model. In this study, we investigated the role of SART1 in antiviral activity of IFN-α against hepatitis B virus (HBV) using blood and liver biopsy samples from chronic hepatitis B patients treated with pegylated IFN-α and HepG2 cells transfected with cloned HBV DNA. We observed that the basal SART1 expression in liver and PBMCs before IFN treatment was significantly higher in responders than in nonresponders. Furthermore, baseline SART1 expression level positively correlated with the degree of HBV DNA and HBeAg decline after IFN treatment. Mechanistically, silencing SART1 abrogated the antiviral activity of IFN-α, reduced the expression of IFN-stimulated genes (ISGs) Mx, OAS, and PKR, and attenuated JAK-STAT signaling in HepG2 cells, suggesting that SART1 regulates IFN-mediated antiviral activity through JAK-STAT signaling and ISG expression. Our study elucidates the important role of SART1 in IFN-mediated anti-HBV response and provides new insights into understanding variation of IFN treatment response in CHB patients.

Role of CYP27B1+2838 promoter polymorphism in the treatment of chronic hepatitis B HBeAg negative with PEG-interferon

2014 ◽  
Vol 22 (3) ◽  
pp. 318-327 ◽  
Author(s):  
L. Boglione ◽  
J. Cusato ◽  
A. De Nicolò ◽  
G. Cariti ◽  
G. Di Perri ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Promoter Polymorphism

Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

2008 ◽  
Vol 48 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Patrick Marcellin ◽  
Françoise Pequignot ◽  
Elisabeth Delarocque-Astagneau ◽  
Jean-Pierre Zarski ◽  
Nathalie Ganne ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Alcohol Consumption ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Hiv Coinfection
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