scholarly journals Insights into the mechanism of a novel shockwave-assisted needle-free drug delivery device driven by in situ-generated oxyhydrogen mixture which provides efficient protection against mycobacterial infections

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Janardhanraj Subburaj ◽  
Akshay Datey ◽  
Jagadeesh Gopalan ◽  
Dipshikha Chakravortty
Keyword(s):  
Drug Delivery ◽  
Free Drug ◽  
Delivery Device ◽  
Mycobacterial Infections ◽  
Drug Delivery Device ◽  
Efficient Protection

Experimental studies on shock wave and particle dynamics in a needle-free drug delivery device

2017 ◽  
Vol 41 ◽  
pp. 390-400 ◽  
Author(s):  
Guang Zhang ◽  
Ik In Lee ◽  
Tokitada Hashimoto ◽  
Toshiaki Setoguchi ◽  
Heuy Dong Kim
Keyword(s):  
Shock Wave ◽  
Drug Delivery ◽  
Experimental Studies ◽  
Particle Dynamics ◽  
Free Drug ◽  
Delivery Device ◽  
Drug Delivery Device

scholarly journals Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures

2021 ◽  
Vol 7 (1) ◽  
pp. eabd4639
Author(s):  
Hyunwoo Joo ◽  
Youngsik Lee ◽  
Jaemin Kim ◽  
Jeong-Suk Yoo ◽  
Seungwon Yoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Survival Rates ◽  
Animal Experiments ◽  
Wearable Devices ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Novel Treatment ◽  
Medical Emergencies

Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.

A study on the gas-solid particle flows in a needle-free drug delivery device

2013 ◽  
Vol 22 (4) ◽  
pp. 340-344 ◽  
Author(s):  
Md. Alim Iftekhar Rasel ◽  
Md. Abu Taher ◽  
H. D. Kim
Keyword(s):  
Drug Delivery ◽  
Solid Particle ◽  
Free Drug ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Particle Flows

scholarly journals Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

2003 ◽  
Vol 51 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Masako Kajihara ◽  
Toshihiko Sugie ◽  
Hiroo Maeda ◽  
Akihiko Sano ◽  
Keiji Fujioka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Water Soluble ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Novel Drug
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