scholarly journals Jakyakgamcho-tang in the relief of delayed-onset muscle soreness in healthy adults: study protocol for a randomized, double-blind, placebo-controlled, crossover design clinical trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Kyungsun Han ◽  
Ojin Kwon ◽  
So-Young Jung ◽  
In-hwa Park ◽  
Man-Suk Hwang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Study Protocol ◽  
Muscle Soreness ◽  
Delayed Onset Muscle Soreness ◽  
Crossover Design ◽  
Healthy Adults ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Delayed Onset

scholarly journals Jakyakgamcho-tang in the Relief of Delayed-Onset Muscle Soreness in Healthy Adults: study protocol for a randomized, double-blind, placebo-controlled, cross-over design clinical trial

2019 ◽  
Author(s):  
Kyungsun Han ◽  
Ojin Kwon ◽  
So-Young Jung ◽  
In-hwa Park ◽  
Man-Suk Hwang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Sports Injuries ◽  
Delayed Onset Muscle Soreness ◽  
Clinical Effects ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Blood Tests ◽  
Delayed Onset

Abstract Background Muscle soreness after exercise, or so-called delayed onset muscle soreness (DOMS), may cause significant changes to muscle function and may increase the risk of sports injuries. Therefore, various therapeutic strategies have been studied to help recovery after exercise. Jakyakgamcho-tang (JGT) is a widely prescribed herbal medicine to treat muscle pain and cramps in traditional Eastern medicine. The aim of this study was to evaluate the effect of JGT for reducing pain and improving muscle damage after exercise. Methods This study is a randomized, double-blind, placebo-controlled, cross-over design clinical trial. A total of 30 healthy male adults will be recruited. Subjects who voluntarily wish to participate in this study will be hospitalized for 4 days. On the first day, the subjects will perform a standardized treadmill exercise for 1 hour to induce DOMS. After the exercise, the subjects will take either JGT or a placebo for 3 days. After a more than 1 week wash-out period, the subjects will repeat the same process with the other drug. Pain intensity, calf circumference, and pain threshold will be measured as outcome measures. Blood tests and blood pressure will be measured as safety assessments. In addition, blood tests for muscle damage and inflammation markers, such as creatine kinase, interleukin-6, and C-reactive protein will be analyzed. Discussion This will be the first trial to assess the effect of JGT on exercise-induced muscle soreness. Our findings will provide valuable data to determine the clinical effects of JGT on DOMS.

scholarly journals Jakyakgamcho-tang in the Relief of Delayed-Onset Muscle Soreness in Healthy Adults: study protocol for a randomized, double-blind, placebo-controlled, cross-over design clinical trial

2020 ◽  
Author(s):  
Kyungsun Han ◽  
Ojin Kwon ◽  
So-Young Jung ◽  
In-hwa Park ◽  
Man-Suk Hwang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Muscle Damage ◽  
Muscle Soreness ◽  
Sports Injuries ◽  
Delayed Onset Muscle Soreness ◽  
Clinical Effects ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Blood Tests ◽  
Delayed Onset

Abstract Background Muscle soreness after exercise, or so-called delayed onset muscle soreness (DOMS), may cause significant changes to muscle function and may increase the risk of sports injuries. Therefore, various therapeutic strategies have been studied to help recovery after exercise. Jakyakgamcho-tang (JGT) is a widely prescribed herbal medicine to treat muscle pain and cramps in traditional Eastern medicine. The aim of this study was to evaluate the effect of JGT for reducing pain and improving muscle damage after exercise. Methods This study is a randomized, double-blind, placebo-controlled, cross-over design clinical trial. A total of 30 healthy male adults will be recruited. Subjects who voluntarily wish to participate in this study will be hospitalized for 4 days. On the first day, the subjects will perform a standardized treadmill exercise for 1 hour to induce DOMS. After the exercise, the subjects will take either JGT or a placebo for 3 days. After a more than 1 week wash-out period, the subjects will repeat the same process with the other drug. Pain intensity, calf circumference, and pain threshold will be measured as outcome measures. Blood tests and blood pressure will be measured as safety assessments. In addition, blood tests for muscle damage and inflammation markers, such as creatine kinase, interleukin-6, and C-reactive protein will be analyzed. Discussion This will be the first trial to assess the effect of JGT on exercise-induced muscle soreness. Our findings will provide valuable data to determine the clinical effects of JGT on DOMS.

scholarly journals The Efficacy and Safety of Shen Guo Lao Nian Granule for Common Cold of Qi-Deficiency Syndrome: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase II Clinical Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-11
Author(s):  
Xuemei Liu ◽  
Juanjuan Fu ◽  
Tao Fan ◽  
Wei Liu ◽  
Hongli Jiang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Study Protocol ◽  
Common Cold ◽  
Dose Group ◽  
Deficiency Syndrome ◽  
Phase Ii Clinical Trial ◽  
High Dose ◽  
Double Blind ◽  
Double Blind Placebo

Background. Common cold is one of the most frequently occurring illnesses in primary healthcare services and represents considerable disease burden. Common cold of Qi-deficiency syndrome (CCQDS) is an important but less addressed traditional Chinese medicine (TCM) pattern. We designed a protocol to explore the efficacy, safety, and optimal dose of Shen Guo Lao Nian Granule (SGLNG) for treating CCQDS. Methods/Design. This is a multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. A total of 240 eligible patients will be recruited from five centers. Patients are randomly assigned to high-dose group, middle-dose group, low-dose group, or control group in a 1 : 1 : 1 : 1 ratio. All drugs are required to be taken 3 times daily for 5 days with a 5-day follow-up period. Primary outcomes are duration of all symptoms, total score reduction on Jackson’s scale, and TCM symptoms scale. Secondary outcomes include every single TCM symptom duration and score reduction, TCM main symptoms disappearance rate, curative effects, and comparison between Jackson’s scale and TCM symptom scale. Ethics and Trial Registration. This study protocol was approved by the Ethics Committee of Clinical Trials and Biomedicine of West China Hospital of Sichuan University (number IRB-2014-12) and registered with the Chinese Clinical Trial Registry (ChiCTR-IPR-15006349).

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