Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan

There has been considerable progress in characterising chronic lymphocytic leukemia with respect to the underlying biology and the corresponding clinical presentation. Most patients with CLL live for years without the need for therapy. This does not hold true for patients that exhibit inactivation of the tumour suppressor p53 or, possibly, its pathway members. Deletions of chromosome 17p and mutations of TP53 are the main characteristic of aggressive and refractory disease. In this review we will outline the current understanding of mechanisms known to contribute to dysfunctional p53 and its connection to microRNAs.

Download Full-text

New Concepts in the Pathogenesis, Diagnosis, Prognostic Factors and Clinical Presentation of Chronic Lymphocytic Leukemia

Reviews in Clinical and Experimental Hematology ◽

10.1046/j.1468-0734.2000.00008.x ◽

2000 ◽

Vol 4 (2) ◽

pp. 103-117 ◽

Cited By ~ 6

Author(s):

Michael Hallek

Keyword(s):

Prognostic Factors ◽

Chronic Lymphocytic Leukemia ◽

Clinical Presentation ◽

Lymphocytic Leukemia ◽

New Concepts

Download Full-text

Successful Outcomes of Severe COVID-19 in Patient with Chronic Lymphocytic Leukemia: Diagnostic Challenges in Immunocompromised Hosts

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2020.044 ◽

2020 ◽

Vol 12 (1) ◽

pp. e2020044

Author(s):

Alexandre Malek

Keyword(s):

Public Health ◽

Chronic Lymphocytic Leukemia ◽

Clinical Presentation ◽

Severe Case ◽

Lymphocytic Leukemia ◽

Health Crisis ◽

Public Health Crisis ◽

Current Outbreak ◽

Novel Coronavirus ◽

Immunocompromised Hosts

The emergence and spread of 2019 novel coronavirus has led to an unprecedented public health crisis around the globe and has threatened the life of millions of people. We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis, treatment and specimens sampling pitfalls. This case highlights the importance of a comprehensive diagnostic approach of pneumonia in immunocompromised hosts, including timely and safe bronchoscopy, because the broad differential diagnosis, more challenging with the current outbreak of COVID-19.

Download Full-text

An unusual clonal chromosome abnormality der(17)t(11;17)(q24;p13)inv(11)(q13;q23) in a patient with chronic lymphocytic leukemia

Archives of Case Reports ◽

10.29328/journal.acr.1001053 ◽

2021 ◽

Vol 5 (2) ◽

pp. 028-031

Author(s):

Monti Valentina ◽

Serpenti Fabio ◽

Farina Lucia ◽

Moiraghi Maria Luisa ◽

Testi Maria Adele ◽

...

Keyword(s):

Chronic Lymphocytic Leukemia ◽

B Lymphocytes ◽

Clinical Presentation ◽

Chromosome Abnormality ◽

Lymphocytic Leukemia ◽

Response To Treatment

Chronic Lymphocytic Leukemia (CLL) is a common clonal neoplasm of small, mature B-lymphocytes. CLL is a heterogeneous disease with different clinical presentation, response to treatment and survival.

Download Full-text