scholarly journals Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Yaqi Wang ◽  
Xiaomin Zhang ◽  
Qiao Song ◽  
Yuli Hou ◽  
Jing Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Chromatin Accessibility ◽  
Ad Mouse Model

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes

2010 ◽  
Vol 1348 ◽  
pp. 149-155 ◽  
Author(s):  
Roxanne Sterniczuk ◽  
Michael C. Antle ◽  
Frank M. LaFerla ◽  
Richard H. Dyck
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Changes ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 1. Circadian changes

2010 ◽  
Vol 1348 ◽  
pp. 139-148 ◽  
Author(s):  
Roxanne Sterniczuk ◽  
Richard H. Dyck ◽  
Frank M. LaFerla ◽  
Michael C. Antle
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Circadian Changes ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model

scholarly journals Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease

2020 ◽  
Vol 10 (4) ◽  
pp. 875-883 ◽  
Author(s):  
Hugo Ferreira ◽  
João Martins ◽  
Ana Nunes ◽  
Paula I. Moreira ◽  
Miguel Castelo-Branco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model

scholarly journals Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease

2021 ◽  
Author(s):  
Dominic I Javonillo ◽  
Kristine M. Tran ◽  
Jimmy Phan ◽  
Edna Hingco ◽  
Enikö A. Kramár ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Models ◽  
Mouse Model ◽  
Long Term Potentiation ◽  
Plaque Burden ◽  
Complex Disorders ◽  
Depth Analysis ◽  
Ad Mouse Model

Animal models of disease are valuable resources for investigating pathogenic mechanisms and potential therapeutic interventions. However, for complex disorders such as Alzheimer's disease (AD), the generation and availability of innumerous distinct animal models present unique challenges to AD researchers and hinder the success of useful therapies. Here, we conducted an in-depth analysis of the 3xTg-AD mouse model of AD across its lifespan to better inform the field of the various pathologies that appear at specific ages, and comment on drift that has occurred in the development of pathology in this line since its development 20 years ago. This modern characterization of the 3xTg-AD model includes an assessment of impairments in behavior, cognition, and long-term potentiation followed by quantification of amyloid beta (Aβ) plaque burden and neurofibrillary tau tangles, biochemical levels of Aβ, and tau protein, and neuropathological markers such as gliosis and accumulation of dystrophic neurites. We also present a novel comparison of the 3xTg-AD model with the 5xFAD model using the same deep-phenotyping characterization pipeline. The results from these analyses are freely available via the AD Knowledge Portal (https://admodelexplorer.synapse.org). Our work demonstrates the utility of a characterization pipeline that generates robust and standardized information relevant to investigating and comparing disease etiologies of current and future models of AD.

Characterization of a 3xTg-AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background

Synapse ◽  
2018 ◽  
Vol 72 (4) ◽  
pp. e22025 ◽  
Author(s):  
Jessica Virgili ◽  
Meryem Lebbadi ◽  
Cyntia Tremblay ◽  
Isabelle St-Amour ◽  
Caroline Pierrisnard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model ◽  
Senescence Accelerated Mouse

scholarly journals Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer’s Disease

2019 ◽  
pp. 1816-1821
Author(s):  
Hugo Ferreira ◽  
João Martins ◽  
Ana Nunes ◽  
Paula I. Moreira ◽  
Miguel Castelo-Branco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model

scholarly journals Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease

2021 ◽  
Author(s):  
Samuel Morabito ◽  
Emily Miyoshi ◽  
Neethu Michael ◽  
Saba Shahin ◽  
Alessandra Cadete Martini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chromatin Accessibility ◽  
Single Nucleus

REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease

Life Sciences ◽  
2014 ◽  
Vol 116 (2) ◽  
pp. 83-89 ◽  
Author(s):  
E. Orta-Salazar ◽  
A. Aguilar-Vázquez ◽  
H. Martínez-Coria ◽  
S. Luquín-De Anda ◽  
M. Rivera-Cervantes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Protein Expression ◽  
Induced Changes ◽  
Ad Mouse Model

Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)

2020 ◽  
Author(s):  
Bernhard Baumann ◽  
Danielle J. Harper ◽  
Antonia Lichtenegger ◽  
Johanna Gesperger ◽  
Tanja Himmel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Optical Coherence Tomography ◽  
Mouse Model ◽  
Optical Coherence ◽  
Model Of Alzheimer’S Disease

scholarly journals Altered slow (<1 Hz) and fast (beta and gamma) neocortical oscillations in the 3xTg-AD mouse model of Alzheimer's disease under anesthesia

2019 ◽  
Vol 79 ◽  
pp. 142-151 ◽  
Author(s):  
Patricia Castano-Prat ◽  
Lorena Perez-Mendez ◽  
Maria Perez-Zabalza ◽  
Coral Sanfeliu ◽  
Lydia Giménez-Llort ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Ad Mouse Model
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