scholarly journals Long-term observation of incremental response and antibodies to voltage-gated calcium channels in patients with Lambert–Eaton myasthenic syndrome: two case reports

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Ilka Schneider ◽  
Malte E Kornhuber ◽  
Frank Hanisch
Keyword(s):  
Calcium Channels ◽  
Case Reports ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Myasthenic Syndrome ◽  
Long Term Observation

scholarly journals Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update

2021 ◽  
Vol 11 (8) ◽  
pp. 1035
Author(s):  
Maria Pia Giannoccaro ◽  
Patrizia Avoni ◽  
Rocco Liguori
Keyword(s):  
Potassium Channels ◽  
Neuromuscular Junction ◽  
Calcium Channels ◽  
Myasthenia Gravis ◽  
Neuromuscular Transmission ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Immune Mediated ◽  
Recent Developments ◽  
Myasthenic Syndrome

The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ.

Interaction of synaptotagmin with voltage gated calcium channels: A role in Lambert-Eaton myasthenic syndrome?

1993 ◽  
Vol 3 (5-6) ◽  
pp. 451-454 ◽  
Author(s):  
Pascale David ◽  
Nicole Martin-Moutot ◽  
Christian Leveque ◽  
Oussama El Far ◽  
Masami Takahashi ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Myasthenic Syndrome

Two Intra-Amygdaloid Pathways to the Central Amygdala Exhibit Different Mechanisms of Long-Term Potentiation

2005 ◽  
Vol 93 (5) ◽  
pp. 3012-3015 ◽  
Author(s):  
Yu Fu ◽  
Patricia Shinnick-Gallagher
Keyword(s):  
Synaptic Plasticity ◽  
Calcium Channels ◽  
Long Term Potentiation ◽  
Central Amygdala ◽  
Voltage Gated ◽  
Emotional Memories ◽  
Voltage Gated Calcium Channels ◽  
Term Potentiation ◽  
Primary Output

Synaptic plasticity in the amygdala is thought to underlie aversive or rewarding learning and emotional memories. In this study, different mechanisms were found to underlie synaptic plasticity in lateral (LA) and basolateral (BLA) amygdala pathways to the primary output nucleus of the amygdala, the central amygdala (CeA). Specifically, 1) long-term potentiation (LTP) at the BLA-CeA synapses was independent of inhibition and mediated through N-methyl-d-aspartate receptors (NMDARs) and L-type voltage-gated calcium channels (VGCCs), and 2) LTP in the LA-CeA pathway was gated by inhibition and mediated through VGCCs but not NMDARs.

The action of Lambert-Eaton myasthenic syndrome immunoglobulin G on cloned human voltage-gated calcium channels

2002 ◽  
Vol 25 (5) ◽  
pp. 715-724 ◽  
Author(s):  
Ashwin Pinto ◽  
Kazuo Iwasa ◽  
Claire Newland ◽  
John Newsom-Davis ◽  
Bethan Lang
Keyword(s):  
Calcium Channels ◽  
Immunoglobulin G ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Myasthenic Syndrome
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