The Efficacy of Downward Counterfactual Thinking for Regulating Emotional Memories in Anxious Individuals

Aversive autobiographical memories sometimes prompt maladaptive emotional responses and contribute to affective dysfunction in anxiety and depression. One way to regulate the impact of such memories is to create a downward counterfactual thought–a mental simulation of how the event could have been worse–to put what occurred in a more positive light. Despite its intuitive appeal, counterfactual thinking has not been systematically studied for its regulatory efficacy. In the current study, we compared the regulatory impact of downward counterfactual thinking, temporal distancing, and memory rehearsal in 54 adult participants representing a spectrum of trait anxiety. Participants recalled regretful experiences and rated them on valence, arousal, regret, and episodic detail. Two to six days later, they created a downward counterfactual of the remembered event, thought of how they might feel about it 10 years from now, or simply rehearsed it. A day later, participants re-rated the phenomenological characteristics of the events. Across all participants, downward counterfactual thinking, temporal distancing, and memory rehearsal were equally effective at reducing negative affect associated with a memory. However, in individuals with higher trait anxiety, downward counterfactual thinking was more effective than rehearsal for reducing regret, and it was as effective as distancing in reducing arousal. We discuss these results in light of the functional theory of counterfactual thinking and suggest that they motivate further investigation into downward counterfactual thinking as a means to intentionally regulate emotional memories in affective disorders.

Time-dependent emotional memory transformation: divergent pathways of item memory and contextual dependency

Emotional memory can persist strikingly long, but it is believed that not all its elements are protected against the fading effects of time. So far, studies of emotional episodic memory have mostly investigated retention up to 24h post-encoding, and revealed that central emotional features (items) are usually strengthened, while contextual binding of the event is reduced. However, even though it is known for neutral memories that central versus contextual elements evolve differently with longer passage of time, the time-dependent evolution of emotional memories remains unclear. Hypothetically, compared to neutral memories, emotional item memory becomes increasingly stronger, accompanied by accelerated decay of – already fragile – links with their original encoding contexts, resulting in progressive reductions in contextual dependency. Here, we tested these predictions in a large-scale study. Participants encoded emotional and neutral episodes, and were assessed 30 minutes (N = 40), one day (N = 40), one week (N = 39), or two weeks (N = 39) later on item memory, contextual dependency, and subjective quality of memory. The results show that, with the passage of time, emotional memories were indeed characterized by increasingly stronger item memory and weaker contextual dependency. Interestingly, analyses of the subjective quality of memories revealed that stronger memory for emotional items with time was expressed in familiarity, whereas increasingly smaller contextual dependency for emotional episodes was reflected in recollection. Together, these findings uncover the time-dependent transformation of emotional episodic memories, thereby shedding light on the ways healthy and maladaptive human memories may develop.

Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia

The idea that maladaptive memories may be rendered susceptible to interference after reactivation raises the possibility of reactivating and neutralizing clinically-relevant emotional memories. In this study, we sought to investigate the feasibility of such a “reconsolidation-based” intervention for arachnophobia, drawing upon previous research that successfully reduced fear of spiders in a subclinical sample. In Experiment 1, we piloted several reactivation procedures for conducting a reconsolidation-based treatment for arachnophobic individuals. All procedures involved some form of brief exposure to a fear-provoking spider, followed by the administration of 40 mg propranolol. In Experiment 2, we conducted a double-blind, placebo-controlled assessment of one procedure tested in Experiment 1. In Experiment 1, we found that most reactivation procedures produced drops in self-reported fear of spiders from pre- to post-treatment, including fear declines that were apparent up to 6- and even 14-months later. However, in Experiment 2, we found no evidence that the participants receiving propranolol were better off than those who received placebo. While our findings are limited by the small sample sizes used, they nevertheless show a different pattern of responses than was observed in a previous reconsolidation-based intervention for subclinical spider fearful participants. Alterations to the protocol made to accommodate the clinical participants may have led to greater opportunities for non-specific effects (e.g., exposure, placebo effects) to drive change in the participants. Our findings highlight both the challenges of translating reconsolidation-based procedures into clinical interventions, as well as the importance of controls for non-specific effects in reconsolidation-based research.

Negotiating Gender in Everyday Life: Toward a Conceptual Model of Gender Dysphoria in Adolescents

A growing number of adolescents are seeking medical care to alleviate gender dysphoria (GD). This qualitative study explored the subjective experiences of GD among help-seeking transgender and gender nonconforming (TGNC) youth in order to develop a more nuanced conceptualization of the phenomenon. Fifteen life-mode interviews were conducted with newly referred youth between the ages of 13 and 19. All participants were assigned female at birth. The data were analyzed using thematic analysis. The participants targeted five major themes that characterize GD: (1) Bodily sensations were constant reminders of GD throughout the day, (2) emotional memories from the past of being different and outside triggered GD, (3) the process of coming out was a transformative experience that changed how the participants understood themselves, (4) GD both increased and decreased in relation to others, (5) everyday life required careful negotiation to feel whole without developing new forms of GD. Based on the results, we suggest a more conceptually nuanced model of GD, one which accounts for how bodily sensations and emotional memories from the past were sources that elicited GD. The sources were mediated through the process of coming out and relating to others, and this resulted in the negotiation of GD today. The conceptual model suggested in the present study could ideally shed light on preexisting knowledge on TGNC youth struggling with GD. In addition, an improved understanding of GD could ideally help clinicians when addressing individual treatment needs.

Neural dynamics of retrieval suppression in abolishing item-specific cortical pattern of unwanted emotional memories

When reminded of an unpleasant experience, people often try to exclude the unwanted memory from awareness in an effort to forget it, a process known as retrieval suppression. Yet, how fast can individual memories be targeted and controlled, and the neural dynamics in modulating cortical traces of individual memories, remain elusive. Here, using multivariate decoding analyses on time-domain and time-frequency-domain EEGs, we found that retrieval suppression of aversive memories was distinct from retrieval and passive viewing, when given a reminder. Specifically, early elevation of mid-frontal theta power during the first 500 ms distinguished retrieval suppression from passive viewing, suggesting that suppression recruited early active control processes. On an item-level, we could discern activities relating to individual memories during active retrieval-initially, based on perceptual responses to reminders (0-500 ms) and later, via the reinstatement and maintenance of the target aversive scenes (500-3000 ms). Critically, suppressing retrieval significantly weakened (during 420-600 ms) and eventually abolished these item-specific cortical patterns till cue disappeared (1200-3000 ms), suggesting the successful exclusion of the unwelcome memory from awareness. Suppression of item-specific cortical patterns bore behavioral consequences in predicting subsequent episodic forgetting. These findings provide unique insight into the neural dynamics underlying the control of unwelcome memories: upon perceiving an unwelcome reminder, people rapidly deploy inhibitory control to truncate retrieval within 500 ms, which likely terminate the reminder-to-memory conversion at around 500 ms that would ordinarily arise through hippocampal pattern completion. We concluded that both rapid and sustained control are critical in abolishing cortical patterns of individual memories, limiting unwelcome awareness, and precipitating later forgetting.

Imagery Rescripting Helps Victims Cope With Experienced Injustice

In clinical psychology, imagery rescripting (ImRs) is a promising intervention to target negative emotional memories after victimization experiences. The present research tested the effects of ImRs in “minor” cases of experienced injustice. After imagining being the victim of an injustice, participants ( N = 272) were randomly assigned to one of four conditions in a univariate design (treatment: active ImRs, passive ImRs; control: pleasant imagery, imagery rehearsal). Dependent variables were positive and negative affect; mediator variables were justice-related satisfaction and empowerment. Both justice-related satisfaction and empowerment increased positive and decreased negative affect, but empowerment was higher in the active than in the passive ImRs condition (while justice-related satisfaction was increased by both ImRs conditions). These results suggest that ImRs can be beneficial even in minor victimization experiences and that these beneficial effects are mediated by both empowerment and justice-related satisfaction.

Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation

Reconsolidation is a process by which memories are destabilized, updated, and then restabilized. Strong memories are resistant to undergoing reconsolidation. Here, we addressed whether an overtrained fear memory could be made susceptible to reconsolidation by first extinguishing, and then renewing, the memory. Rats were trained with ten tone-footshock pairings, followed by eight days of tone extinction in the training context. The next day, rats were placed into a second context and memory for the tone was renewed/reactivated with a single tone presentation. Immediately following reactivation, rats received an injection of midazolam or vehicle. Rats were then tested for freezing to the tone in a third context. Midazolam had no effect in rats that did not undergo tone extinction, but significantly attenuated freezing to the tone in extinguished rats. Thus, rats that received tone extinction underwent tone memory reconsolidation following its renewal. In a second experiment, we administered the reactivation session and midazolam injections prior to extinction. Midazolam had no effect and rats extinguished at a rate similar to controls. These data suggest that strong emotional memories are capable of updating following weakening of memory expression through extinction.