Treatment outcomes in patients with opioid use disorder initiated by prescription: a systematic review protocol

Abstract Background Although medications for opioid use disorder (MOUD) models are the most efficacious evidence-based treatment for opioid use disorder, there remains a high percentage of patients experiencing unfavorable treatment outcomes. Greater understanding of how social network support functions with respect to MOUD treatment outcomes may possibly increase treatment outcomes. Social network support are the kinds of support, such as assistance or help, that people receive from friends, family, peers and neighbors, paid or unpaid, in their social network. We aim to provide quality evidence to understand the role of social network support on MOUD treatment outcomes. Methods A systematic review of experimental and observational studies will be conducted. PubMed, MEDLINE, Embase, PsycINFO and Sociological Abstracts will be searched, updated to capture current literature. Primary outcomes will include adherence to MOUD, defined as continuation in or completion of an MOUD program; and opioid use, defined as the percentage of urine samples negative for opioids and/or self-reported drug use. The systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Quality assessments will be conducted using criteria from the Cochrane Handbook. A narrative synthesis will be conducted for all included studies. Discussion This systematic review seeks to provide policymakers, administrators, practitioners and researchers with a systematic and reproducible strategy to query the literature around the role of social network support on MOUD treatment outcomes. Systematic review registration International Prospective Register for Systematic Reviews (PROSPERO), CRD42018095645.

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The role of social network support in treatment outcomes for medication for opioid use disorder: A systematic review

Journal of Substance Abuse Treatment ◽

10.1016/j.jsat.2021.108367 ◽

2021 ◽

pp. 108367

Author(s):

Navin Kumar ◽

William Oles ◽

Benjamin A. Howell ◽

Kamila Janmohamed ◽

Selena T. Lee ◽

...

Keyword(s):

Systematic Review ◽

Social Network ◽

Treatment Outcomes ◽

Opioid Use Disorder ◽

Opioid Use ◽

Network Support ◽

Social Network Support

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The role of social network support on treatment outcomes for medication for opioid use disorder: a systematic review protocol

10.21203/rs.2.20720/v2 ◽

2020 ◽

Author(s):

Navin Kumar ◽

Benjamin A. Howell ◽

Marcus Alexander ◽

Patrick G. O'Connor

Keyword(s):

Systematic Review ◽

Social Network ◽

Treatment Outcomes ◽

Systematic Reviews ◽

Opioid Use Disorder ◽

Opioid Use ◽

Support Functions ◽

Network Support ◽

Social Network Support

Abstract Background Although medications for opioid use disorder (MOUD) models are the most efficacious evidence-based treatment for opioid use disorder, there remains a high percentage of patients experiencing unfavorable treatment outcomes. Greater understanding of how social network support functions with respect to MOUD treatment outcomes may possibly improve treatment outcomes. Social network support are the kinds of support, such as assistance or help, that people receive from friends, family, peers and neighbors, paid or unpaid, in their social network. We aim to provide quality evidence to understand the role of social network support on MOUD treatment outcomes. Methods A systematic review of experimental and observational studies will be conducted. PubMed, MEDLINE, Embase, PsycINFO and Sociological Abstracts will be searched. Primary outcomes will include adherence to MOUD, defined as continuation in or completion of an MOUD program; and opioid use, defined as the percentage of urine samples negative for opioids and/or self-reported drug use. The systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Quality assessments will be conducted using criteria from the Cochrane Handbook. A narrative synthesis will be conducted for all included studies. Discussion This systematic review seeks to provide policymakers, administrators, practitioners and researchers with a systematic and reproducible strategy to query the literature around the role of social network support on MOUD treatment outcomes. Systematic review registration International Prospective Register for Systematic Reviews (PROSPERO), CRD42018095645.

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Treatment Outcomes in Patients With Opioid Use Disorder Who Were First Introduced to Opioids by Prescription: A Systematic Review and Meta-Analysis

Frontiers in Psychiatry ◽

10.3389/fpsyt.2020.00812 ◽

2020 ◽

Vol 11 ◽

Author(s):

Nitika Sanger ◽

Meha Bhatt ◽

Nikhita Singhal ◽

Balpreet Panesar ◽

Alessia D’Elia ◽

...

Keyword(s):

Systematic Review ◽

Treatment Outcomes ◽

Meta Analysis ◽

Opioid Use Disorder ◽

Opioid Use

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Perioperative Dexmedetomidine Infusion, as Opioid-Sparing Strategy, in Patients Undergoing General Anesthesia: A Systematic Review Protocol

The Open Anesthesia Journal ◽

10.2174/2589645801913010139 ◽

2019 ◽

Vol 13 (1) ◽

pp. 139-143 ◽

Cited By ~ 1

Author(s):

Marco Fiore ◽

Aniello Alfieri ◽

Maria B. Passavanti ◽

Anna Battimelli ◽

Alessia Gatani ◽

...

Keyword(s):

Systematic Review ◽

General Anesthesia ◽

Pain Control ◽

Meta Analysis ◽

Secondary Outcome ◽

Systematic Review Protocol ◽

Opioid Use ◽

Opioid Sparing ◽

Review Protocol ◽

Sparing Effect

Introduction: Although there are multiple analgesia techniques, opioids remain the most widely used drug for pain control. Postoperative Nausea and Vomiting (PONV), sleepiness, respiratory, and gastrointestinal disorder are common complications of postoperative opioid use, which makes the decrease in opioid demand, through combination with non-opioid agents, desirable. Dexmedetomidine (DEX) is an alpha2-adrenergic agonist with sedative and anxiolytic effects. Recently, some studies proved the evidence of its notable opioid-sparing effect. Furthermore DEX, compared to opioids, seems to have the advantage of not inhibiting spontaneous breathing. Aim: This systematic review protocol aims to define the analgesic effect of perioperative DEX infusion and the cumulative opioid consumption of patients undergoing general anesthesia. Methods: The review will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta- Analysis Protocols (PRISMA- P) statement and the Cochrane recommendations for Systematic Reviews of Interventions. Results: The primary outcomes will be 1) The effect of DEX infusion, on pain control, compared to placebo or other treatments and 2) The opioid-sparing effect of DEX infusion compared to placebo or other treatments. The secondary outcome will be a) Respiratory depression, b) Hypotension requiring fluid infusion and/or amine, c) Bradycardia requiring vasoactive drugs, d) Needing of prolonged hospital stay, e) PONV and gastrointestinal disorders. Conclusion: A sub-analysis is planned for i) The type of surgery performed, ii) Patient’s gender, iii) Patients age. If possible, a meta- analysis (including sub-analysis and sensitivity analysis for all assessed outcomes) will be performed. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach will be followed to create a Summary of Findings. The Registration Number for this Systematic Review is CRD42018086687.

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Sleep and cognition in schizophrenia spectrum disorders: A systematic review protocol.

10.31234/osf.io/cbxud ◽

2020 ◽

Author(s):

Sean Carruthers ◽

Gemma Brunetti ◽

Susan Rossell

Keyword(s):

Systematic Review ◽

Mental Illnesses ◽

Schizophrenia Spectrum Disorders ◽

Systematic Review Protocol ◽

Schizophrenia Spectrum Disorder ◽

Schizophrenia Spectrum ◽

Review Protocol ◽

Spectrum Disorders ◽

Sleep And Cognition ◽

The Relationship

Schizophrenia spectrum disorders are chronic and debilitating mental illnesses characterised by both cognitive impairments and sleep deficits. In this systematic review protocol, we outline an approach to examine the available literature investigating the relationship between sleep and cognition in individuals with schizophrenia spectrum disorder.

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