Development and validation of a simple and rapid ICP-OES method for quantification of elemental impurities in voriconazole drug substance

Abstract Background The aim of the present study was to develop and validate an inductively coupled plasma optical emission spectroscopic (ICP–OES) method for quantification of elemental impurities, i.e., Lead, Palladium, and Zinc, in voriconazole drug substance, and this method was employed for the regular sample analysis of Lead, Palladium, and Zinc in voriconazole drug substance for pharmaceutical use. The method has been validated using RF power of 1150 W, auxiliary gas of 0.5 L/min, and nebulizer flow of 0.4 L/min and plasma view at axial mode for Lead and Palladium and radial mode for Zinc. The wavelength was monitored for Lead, Palladium, and Zinc at 220.3 nm, 340.4 nm, and 213.8 nm respectively. Results The method is selective and is capable of detecting desired elemental impurities with regulatory acceptance limits in the presence of other elements. The validation experiments involve the demonstration of system suitability, specificity, LOD and LOQ, linearity, precision, and accuracy experiments. The linearity results obtained ˃ 0.9990 for all three impurities. Conclusion The proposed method is simple, sensitive quality control tool for the simultaneous quantitative determination of Lead, Palladium, and Zinc at low levels in voriconazole drug substance. Graphical abstract

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Trace Elemental Analysis of Bulk Thorium Using an Automated Separation–Inductively Coupled Plasma Optical Emission Spectroscopy Methodology

Applied Spectroscopy ◽

10.1177/0003702820961390 ◽

2020 ◽

pp. 000370282096139

Author(s):

Benjamin T. Manard ◽

Shalina C. Metzger ◽

Sarah K. Wysor ◽

Veronica C. Bradley ◽

Benjamin D. Roach ◽

...

Keyword(s):

Trace Element ◽

Inductively Coupled Plasma ◽

Emission Spectroscopy ◽

Optical Emission Spectroscopy ◽

Optical Emission ◽

Icp Oes ◽

Inductively Coupled ◽

Elemental Impurities ◽

Trace Elemental ◽

Automated Platform

Presented here is a novel automated method for determining the trace element composition of bulk thorium by inductively coupled plasma–optical emission spectroscopy (ICP-OES). ICP-OES is a universal approach for measuring the trace elemental impurities present in actinide-rich materials; however, due to the emission rich spectrum of the actinide, a separation from the trace elements is warranted for spectrochemical analysis. Here, AG MP-1 ion exchange resin was utilized for retention of the Th matrix, while allowing the trace element impurities to be separated prior to subsequent analysis using ICP-OES. After demonstrating the separation on traditional gravity-driven columns, the methodology was transitioned to an automated platform for comparison. This automated platform utilizes syringe-driven sample and solvent flow and can collect the trace element and thorium fractions in separate locations. While reducing the sample size (500 µL, 1.5 mg of Th), maintaining the overall separation efficiency (recoveries >95%), and illustrating the sample throughput ability (n = 10+), this automated methodology could be readily adopted to nuclear facilities in which the determination of trace elemental impurities in Th samples is warranted.

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10.3403/30373495 ◽

2019 ◽

Keyword(s):

Inductively Coupled Plasma ◽

Chemical Species ◽

Optical Emission ◽

Icp Oes ◽

Species Determination ◽

Inductively Coupled

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An on-line matrix separation and preconcentration procedure for ICP-OES determination of Cd, Co, Cu, Mn and Pb traces in Zr and Zr-Nb alloys using a cation-exchange resin microcolumn

Journal of Analytical Atomic Spectrometry ◽

10.1039/d1ja00033k ◽

2021 ◽

Author(s):

Masoud Aghahoseini ◽

Gholamhassan Azimi ◽

M. K. Amini

Keyword(s):

Inductively Coupled Plasma ◽

Cation Exchange Resin ◽

Optical Emission ◽

Emission Spectrometry ◽

Icp Oes ◽

Inductively Coupled ◽

Separation And Preconcentration ◽

On Line ◽

Plasma Optical Emission Spectrometry

Determination of traces of Cd, Co, Cu, Mn and Pb elements in zirconium and its alloys by inductively coupled plasma optical emission spectrometry (ICP OES) suffers from severe spectral interferences...

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