scholarly journals Human adipose-derived stem cell transplantation as a potential therapy for collagen VI-related congenital muscular dystrophy

2014 ◽  
Vol 5 (1) ◽  
pp. 21 ◽  
Author(s):  
Vitali Alexeev ◽  
Machiko Arita ◽  
Adele Donahue ◽  
Paolo Bonaldo ◽  
Mon-Li Chu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Muscular Dystrophy ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Congenital Muscular Dystrophy ◽  
Collagen Vi ◽  
Adipose Derived Stem Cell

Effects of xenogeneic adipose-derived stem cell transplantation on acute-on-chronic liver failure

2013 ◽  
Vol 12 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Wei Zhu ◽  
Xiao-Lei Shi ◽  
Jiang-Qiang Xiao ◽  
Guang-Xiang Gu ◽  
Yi-Tao Ding ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Liver Failure ◽  
Cell Transplantation ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Adipose Derived Stem Cell

Adipose-derived stem cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy

2021 ◽  
Vol 1750 ◽  
pp. 147121
Author(s):  
Lili Wang ◽  
Yingchun Zhao ◽  
Xiaochun Pan ◽  
Yu Zhang ◽  
Lin Lin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Temporal Lobe Epilepsy ◽  
Learning And Memory ◽  
Cell Transplantation ◽  
Temporal Lobe ◽  
Rat Model ◽  
Adipose Derived Stem Cell

scholarly journals Congenital muscular dystrophy-associated inflammatory chemokines provide axes for effective recruitment of therapeutic adult stem cell into muscles

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Vitali Alexeev ◽  
Jacquelyn Olavarria ◽  
Paolo Bonaldo ◽  
Luciano Merlini ◽  
Olga Igoucheva
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Muscular Dystrophy ◽  
Continuous Production ◽  
Neuromuscular Disorders ◽  
Congenital Muscular Dystrophy ◽  
Entire Body ◽  
Collagen Vi ◽  
Directional Migration ◽  
Term Survival

Abstract Background Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness. The two most prevalent forms of CMD, collagen VI-related myopathies (COL6RM) and laminin α2 deficient CMD type 1A (MDC1A), are both caused by deficiency or dysfunction of extracellular matrix proteins. Previously, we showed that an intramuscular transplantation of human adipose-derived stem cells (ADSC) into the muscle of the Col6a1−/− mice results in efficient stem cell engraftment, migration, long-term survival, and continuous production of the collagen VI protein, suggesting the feasibility of the systemic cellular therapy for COL6RM. In order for this therapeutic approach to work however, stem cells must be efficiently targeted to the entire body musculature. Thus, the main goal of this study is to test whether muscle homing of systemically transplanted ADSC can be enhanced by employing muscle-specific chemotactic signals originating from CMD-affected muscle tissue. Methods Proteomic screens of chemotactic molecules were conducted in the skeletal muscles of COL6RM- and MDC1A-affected patients and CMD mouse models to define the inflammatory and immune activities, thus, providing potential markers of disease activity or treatment effect. Also using a pre-clinical animal model, recapitulating mild Ullrich congenital muscular dystrophy (UCMD), the therapeutic relevance of identified chemotactic pathways was investigated in vivo, providing a basis for future clinical investigations. Results Comprehensive proteomic screens evaluating relevant human and mouse skeletal muscle biopsies offered chemotactic axes to enhance directional migration of systemically transplanted cells into CMD-affected muscles, including CCL5-CCR1/3/5, CCL2-CCR2, CXCL1/2-CXCR1,2, and CXCL7-CXCR2. Also, the specific populations of ADSC selected with an affinity for the chemokines being released by damaged muscle showed efficient migration to injured site and presented their therapeutic effect. Conclusions Collectively, identified molecules provided insight into the mechanisms governing directional migration and intramuscular trafficking of systemically infused stem cells, thus, permitting broad and effective application of the therapeutic adult stem cells for CMD treatment.

scholarly journals The Relative Contribution of Paracine Effect versus Direct Differentiation on Adipose-Derived Stem Cell Transplantation Mediated Cardiac Repair

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59020 ◽  
Author(s):  
Dezhong Yang ◽  
Wei Wang ◽  
Liangpeng Li ◽  
Yulan Peng ◽  
Peng Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Cardiac Repair ◽  
Direct Differentiation ◽  
Relative Contribution ◽  
Adipose Derived Stem Cell

scholarly journals Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage

2013 ◽  
Vol 4 (4) ◽  
pp. 91 ◽  
Author(s):  
Phuc Van Pham ◽  
Khanh Hong-Thien Bui ◽  
Dat Ngo ◽  
Ngoc Vu ◽  
Nhung Truong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Articular Cartilage ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Platelet Rich Plasma ◽  
Adipose Derived Stem Cell

scholarly journals Paracrine Mechanism of Angiogenesis in Adipose-Derived Stem Cell Transplantation

2014 ◽  
Vol 72 (2) ◽  
pp. 234-241 ◽  
Author(s):  
Hirotaka Suga ◽  
Jason P. Glotzbach ◽  
Michael Sorkin ◽  
Michael T. Longaker ◽  
Geoffrey C. Gurtner
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Adipose Derived Stem Cell

scholarly journals Congenital muscular dystrophy-associated inflammatory chemokines provide axes for effective recruitment of therapeutic adult stem cell into muscles

2020 ◽  
Author(s):  
Vitali Alexeev ◽  
Jacquelyn Olavarria ◽  
Paolo Bonaldo ◽  
Luciano Merlini ◽  
Olga Igoucheva
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Muscular Dystrophy ◽  
Continuous Production ◽  
Neuromuscular Disorders ◽  
Congenital Muscular Dystrophy ◽  
Entire Body ◽  
Collagen Vi ◽  
Directional Migration ◽  
Term Survival

Abstract Background: Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness. The two most prevalent forms of CMD, collagen VI-related myopathies (COL6RM) and laminin a2 deficient CMD type 1A (MDC1A), are both caused by deficiency or dysfunction of extracellular matrix proteins. Previously, we showed that an intramuscular transplantation of human adipose-derived stem cells (ADSC) into the muscle of the Col6a1-/- mice results in efficient stem cell engraftment, migration, long-term survival, and continuous production of the collagen VI protein, suggesting the feasibility of the systemic cellular therapy for COL6RM. In order for this therapeutic approach to work however, stem cells must be efficiently targeted to the entire body musculature. Thus, the main goal of this study is to test whether muscle homing of systemically transplanted ADSC can be enhanced by employing muscle-specific chemotactic signals originating from CMD-affected muscle tissue. Methods: Proteomic screens of chemotactic molecules were conducted in the skeletal muscles of COL6RM- and MDC1A-affected patients and CMD mouse models to define the inflammatory and immune activities, thus, providing potential markers of disease activity or treatment effect. Also using a pre-clinical animal model, recapitulating mild Ullrich congenital muscular dystrophy (UCMD), the therapeutic relevance of identified chemotactic pathways was investigated in vivo, providing a basis for future clinical investigations.Results: Comprehensive proteomic screens evaluating relevant human and mouse skeletal muscle biopsies offered chemotactic axes to enhance directional migration of systemically transplanted cells into CMD-affected muscles, including CCL5-CCR1/3/5, CCL2-CCR2, CXCL1/2-CXCR1,2 and CXCL7-CXCR2. Also, the specific populations of ADSC selected with an affinity for the chemokines being released by damaged muscle showed efficient migration to injured site and presented their therapeutic effect.Conclusions: Collectively, identified molecules provided insight into the mechanisms governing directional migration and intra-muscular trafficking of systemically infused stem cells, thus, permitting broad and effective application of the therapeutic adult stem cells for CMD treatment.

scholarly journals Electrophysiological consequence of adipose-derived stem cell transplantation in infarcted porcine myocardium

EP Europace ◽  
2007 ◽  
Vol 9 (12) ◽  
pp. 1218-1221 ◽  
Author(s):  
P. Fotuhi ◽  
Y.-H. Song ◽  
E. Alt
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Adipose Derived Stem Cell

scholarly journals Vitamin C Improves Therapeutic Effects of Adipose-derived Stem Cell Transplantation in Mouse Tendonitis Model

In Vivo ◽  
2017 ◽  
Vol 31 (3) ◽  
pp. 343-348 ◽  
Author(s):  
KYUNG-KU KANG ◽  
EUN-JOO LEE ◽  
YOUG-DEUK KIM ◽  
MYUNG-JIN CHUNG ◽  
JUN-YOUNG KIM ◽  
...  
Keyword(s):  
Stem Cell ◽  
Vitamin C ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Effects ◽  
Adipose Derived Stem Cell

Adipose-derived stem cell transplantation for therapeutic lymphangiogenesis in a mouse secondary lymphedema model

2015 ◽  
Vol 10 (5) ◽  
pp. 549-562 ◽  
Author(s):  
Shuhei Yoshida ◽  
Rodrigo Hamuy ◽  
Yuuichi Hamada ◽  
Hiroshi Yoshimoto ◽  
Akiyoshi Hirano ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Secondary Lymphedema ◽  
Adipose Derived Stem Cell
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