A Controlled Comparison of Fluoxetine and Amitriptyline in Depressed Out-patients

1987 ◽  
Vol 151 (3) ◽  
pp. 337-340 ◽  
Author(s):  
J. P. R. Young ◽  
A. Coleman ◽  
M. H. Lader
Keyword(s):  
Sleep Disturbances ◽  
Treated Group ◽  
Blind Study ◽  
Serotonin Uptake ◽  
Dry Mouth ◽  
Selective Serotonin ◽  
Double Blind Study ◽  
Double Blind ◽  
Uptake Inhibitor ◽  
Serotonin Uptake Inhibitor

Fluoxetine, a selective serotonin uptake inhibitor (mean dose 73 mg each morning) was compared with amitriptyline (mean dose 122 mg at night) in a double-blind study of 64 depressed out-patients. Fifty patients completed the 6-week trial. The drugs did not differ with respect to psychiatrists' ratings, but amitriptyline was slightly superior with respect to patients' ratings. The amitriptyline-treated group had complaints of dry mouth and dizziness on standing; the fluoxetine-treated group of sleep disturbances, nausea, and headaches.

Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine

1988 ◽  
Vol 94 (1) ◽  
pp. 141-143 ◽  
Author(s):  
William F. Byerley ◽  
Elizabeth J. McConnell ◽  
R. Tyler McCabe ◽  
Ted M. Dawson ◽  
Bernard I. Grosser ◽  
...  
Keyword(s):  
Rat Brain ◽  
Adrenergic Receptors ◽  
Chronic Administration ◽  
Serotonin Uptake ◽  
Selective Serotonin ◽  
Beta Adrenergic Receptors ◽  
Beta Adrenergic ◽  
Uptake Inhibitor ◽  
Serotonin Uptake Inhibitor

A Double-Blind Out-Patient Trial of Indalpine vs Mianserin

1985 ◽  
Vol 147 (3) ◽  
pp. 306-309 ◽  
Author(s):  
G. J. Naylor ◽  
B. Martin
Keyword(s):  
Side Effects ◽  
Treated Group ◽  
Blind Study ◽  
Antidepressant Effect ◽  
Double Blind Study ◽  
Double Blind ◽  
Significant Difference

SummaryIndalpine 150 mg per day and mianserin 60 mg per day were compared in a double-blind study of 65 depressed out-patients: 52 patients completed the 4-week trial. At the end of four weeks there was no significant difference in antidepressant effect between the two drugs; but in the first two weeks, improvement in the mianserin-treated group was significantly greater than that in the indalpine group. The mianserin-treated group reported more side-effects of sedation (eg. drowsiness, clumsiness, heaviness of limbs etc.) and one patient on indalpine developed a mild leucopenia.

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