Paclitaxel Pharmacokinetics, Threshold Models, and Dosing Strategies

2003 ◽  
Vol 21 (14) ◽  
pp. 2803-2804 ◽  
Author(s):  
Alex Sparreboom ◽  
Jaap Verweij
Keyword(s):  
Threshold Models ◽  
Dosing Strategies

Lithium: Serum levels, renal effects, and dosing strategies

1992 ◽  
Vol 28 (4) ◽  
pp. 355-362 ◽  
Author(s):  
Michael J. Gitlin
Keyword(s):  
Serum Levels ◽  
Renal Effects ◽  
Dosing Strategies

scholarly journals Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Robert Qaqish ◽  
Yui Watanabe ◽  
Marcos Galasso ◽  
Cara Summers ◽  
A adil Ali ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Lung Lavage ◽  
Post Injury ◽  
Surfactant Replacement ◽  
Recruitment Maneuvers ◽  
Surfactant Replacement Therapy ◽  
Dosing Strategies ◽  
Yorkshire Pigs ◽  
Saline Lavage ◽  
Protective Systems

Abstract Background There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems that become deranged in ARDS such as surfactant. Although results of surfactant replacement therapy (SRT) in ARDS have been mixed, questions remain incompletely answered regarding timing and dosing strategies of surfactant. Furthermore, there are only few truly clinically relevant ARDS models in the literature. The primary aim of our study was to create a clinically relevant, reproducible model of severe ARDS requiring extracorporeal membrane oxygenation (ECMO). Secondly, we sought to use this model as a platform to evaluate a bronchoscopic intervention that involved saline lavage and SRT. Methods Yorkshire pigs were tracheostomized and cannulated for veno-venous ECMO support, then subsequently given lung injury using gastric juice via bronchoscopy. Animals were randomized post-injury to either receive bronchoscopic saline lavage combined with SRT and recruitment maneuvers (treatment, n = 5) or recruitment maneuvers alone (control, n = 5) during ECMO. Results PaO2/FiO2 after aspiration injury was 62.6 ± 8 mmHg and 60.9 ± 9.6 mmHg in the control and treatment group, respectively (p = 0.95) satisfying criteria for severe ARDS. ECMO reversed the severe hypoxemia. After treatment with saline lavage and SRT during ECMO, lung physiologic and hemodynamic parameters were not significantly different between treatment and controls. Conclusions A clinically relevant severe ARDS pig model requiring ECMO was established. Bronchoscopic saline lavage and SRT during ECMO did not provide a significant physiologic benefit compared to controls.

scholarly journals Evaluation of Direct Oral Anticoagulant Prescribing in Patients With Moderate to Severe Renal Impairment

2021 ◽  
Vol 27 ◽  
pp. 107602962098790
Author(s):  
Clara Ting ◽  
Megan Rhoten ◽  
Jillian Dempsey ◽  
Hunter Nichols ◽  
John Fanikos ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Renal Impairment ◽  
Severe Renal Impairment ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Bleeding Events ◽  
Increase Risk ◽  
Severe Chronic Kidney Disease ◽  
Dosing Strategies ◽  
Require Dose

Patients with renal impairment require dose adjustments for direct oral anticoagulants (DOACs), though there is uncertainty regarding their use in severe chronic kidney disease. Inappropriately dosed DOACs may increase risk of ischemic events when under-dosed, or risk of bleeding when over-dosed. The purpose of this study was to describe DOAC selection, dosing strategies, and associated clinical outcomes in patients with moderate to severe renal impairment at our institution. This was a single-center retrospective analysis of adult outpatients with moderate to severe renal impairment (estimated creatinine clearance <50 mL/min, including need for hemodialysis) who were prescribed a DOAC by a cardiologist between June 1, 2015 and December 1, 2018. Outcomes evaluated included the percentage of patients who received appropriate and inappropriate DOAC dosing, prescriber reasons for inappropriate DOAC dosing if documented, and incidence of thrombotic and bleeding events. A total of 207 patients were included. Overall, 61 (29.5%) patients received inappropriate dosing, with 43 (70.5%) being under-dosed and 18 (29.5%) being over-dosed as compared to FDA-labeled dosing recommendations for atrial fibrillation or venous thromboembolism (VTE). By a median follow-up duration of 20 months, stroke occurred in 6 (3.3%) patients receiving DOACs for atrial fibrillation, and VTE occurred in 1 (4.3%) patient receiving a DOAC for VTE. International Society on Thrombosis and Haemostasis major or clinically relevant nonmajor bleeding occurred in 25 (12.1%) patients. Direct oral anticoagulants were frequently prescribed at off-label doses in patients with moderate to severe renal impairment, with a tendency toward under-dosing.

Genetic Models of Affective Disorder: Application to Twin Data

1980 ◽  
Vol 29 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Miron Baron
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Monozygotic Twins ◽  
Threshold Models ◽  
Twin Data ◽  
Bipolar Illness ◽  
Major Locus ◽  
Unipolar Disorder ◽  
Locus Model ◽  
Multiple Threshold

Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.

scholarly journals Frequentist model averaging for threshold models

2018 ◽  
Vol 71 (2) ◽  
pp. 275-306 ◽  
Author(s):  
Yan Gao ◽  
Xinyu Zhang ◽  
Shouyang Wang ◽  
Terence Tai-leung Chong ◽  
Guohua Zou
Keyword(s):  
Model Averaging ◽  
Threshold Models ◽  
Frequentist Model Averaging

scholarly journals Asymmetric capital structure adjustments: New evidence from dynamic panel threshold models

2012 ◽  
Vol 19 (4) ◽  
pp. 465-482 ◽  
Author(s):  
Viet Anh Dang ◽  
Minjoo Kim ◽  
Yongcheol Shin
Keyword(s):  
Capital Structure ◽  
Threshold Models ◽  
Dynamic Panel ◽  
New Evidence

scholarly journals Dynamic network signal processing using latent threshold models

2015 ◽  
Vol 47 ◽  
pp. 5-16 ◽  
Author(s):  
Jouchi Nakajima ◽  
Mike West
Keyword(s):  
Signal Processing ◽  
Dynamic Network ◽  
Threshold Models

Dosing Strategies for Antiplatelet Therapy in Percutaneous Coronary Intervention

2010 ◽  
Vol 38 (2) ◽  
pp. 50-58 ◽  
Author(s):  
Gilles Lemesle ◽  
Gabriel Maluenda ◽  
Laurent Bonello ◽  
Cédric Delhaye ◽  
Arnaud Sudre ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Antiplatelet Therapy ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
Dosing Strategies
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