Phase I accelerated dose-escalation, pharmacokinetic (PK) and pharmacodynamic study of PF-03814735, an oral aurora kinase inhibitor, in patients with advanced solid tumors: Preliminary results

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 2517-2517 ◽  
Author(s):  
S. F. Jones ◽  
H. A. Burris ◽  
H. Dumez ◽  
J. R. Infante ◽  
C. Fowst ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Kinase Inhibitor ◽  
Aurora Kinase ◽  
Advanced Solid Tumors ◽  
Aurora Kinase Inhibitor ◽  
Preliminary Results ◽  
Pharmacodynamic Study

scholarly journals Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of ENMD-2076, a Novel Angiogenic and Aurora Kinase Inhibitor, in Patients with Advanced Solid Tumors

2010 ◽  
Vol 17 (4) ◽  
pp. 849-860 ◽  
Author(s):  
Jennifer R. Diamond ◽  
Bruno R. Bastos ◽  
Ryan J. Hansen ◽  
Daniel L. Gustafson ◽  
S. Gail Eckhardt ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Kinase Inhibitor ◽  
Aurora Kinase ◽  
Advanced Solid Tumors ◽  
Aurora Kinase Inhibitor ◽  
Pharmacodynamic Study

scholarly journals Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors

2010 ◽  
Vol 67 (2) ◽  
pp. 305-314 ◽  
Author(s):  
Anne M. Traynor ◽  
Maureen Hewitt ◽  
Glenn Liu ◽  
Keith T. Flaherty ◽  
Jason Clark ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Kinase Inhibitor ◽  
Aurora Kinase ◽  
Adult Patients ◽  
Advanced Solid Tumors ◽  
Aurora Kinase Inhibitor ◽  
Dose Escalation Study

A first-in-human (FIH) phase I study of SAR125844, a novel selective MET kinase inhibitor, in patients (pts) with advanced solid tumors: Dose escalation results.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 2506-2506 ◽  
Author(s):  
Eric Angevin ◽  
Gianluca Spitaleri ◽  
Antoine Hollebecque ◽  
Tommaso De Pas ◽  
Jean-Charles Soria ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Advanced Solid Tumors
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