Predictive role of carcinoembryonic antigen (CEA) for therapeutic efficacy of angiogenesis-targeting therapy in colorectal cancer: Novel clinical observation based upon recently discovered CEA biology.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 3574-3574 ◽  
Author(s):  
K. H. Bramswig ◽  
G. W. Prager ◽  
A. Martel ◽  
G. Heinze ◽  
B. R. Binder ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Therapeutic Efficacy ◽  
Clinical Observation ◽  
Targeting Therapy ◽  
Predictive Role

scholarly journals Predictive Value of UGT1A1 Polymorphisms in Irinotecan-Induced Toxicity and Therapeutic Efficacy in Colorectal Cancer Patients

2020 ◽  
Vol 4 (2) ◽  
pp. 39-46
Author(s):  
Qianqian Yu ◽  
Zhihuan Li ◽  
Xiaoqi Nie ◽  
Lu Wang ◽  
Chen Gong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Metabolic Pathways ◽  
Therapeutic Efficacy ◽  
Advanced Colorectal Cancer ◽  
Inactive Form ◽  
Predictive Role ◽  
Colorectal Cancer Patients ◽  
The Impact

Irinotecan-based chemotherapy is a fundamental cytotoxic regimen for advanced colorectal cancer. The disposition of irinotecan is known to vary in a fashion partially depending on genetic variations in the drug metabolic pathways. UDP-glucuronosyltransferase (UGT)1A1 is a predominant enzyme that converts the active metabolite of irinotecan to the inactive form via a glucuronidation process. Several UGT1A1 polymorphisms are linked to SN-38 glucuronidation and irinotecan-related adverse events, while the predictive role of UGT1A1 polymorphisms regarding therapeutic outcome is controversial. In this review, we will evaluate the impact of UGT1A1 genotypes on irinotecan-induced toxicity and therapeutic efficacy in colorectal cancer patients receiving irinotecan-based treatment.

scholarly journals Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ying-nan Yang ◽  
Rui Zhang ◽  
Jing-wen Du ◽  
Heng-heng Yuan ◽  
Yan-jing Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Predictive Role

Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: A meta-analysis

2015 ◽  
Vol 51 (5) ◽  
pp. 587-594 ◽  
Author(s):  
Filippo Pietrantonio ◽  
Fausto Petrelli ◽  
Andrea Coinu ◽  
Maria Di Bartolomeo ◽  
Karen Borgonovo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
Meta Analysis ◽  
Braf Mutations ◽  
Predictive Role

scholarly journals Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Eng-Yen Huang ◽  
Jen-Chieh Chang ◽  
Hong-Hwa Chen ◽  
Chieh-Ying Hsu ◽  
Hsuan-Chih Hsu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Carcinoembryonic Antigen ◽  
Potential Role
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