Clinicopathological features of program death ligand-1 (PD-L1) expression with tumor-infiltrating lymphocytes (TILs), mismatch repair (MMR) and Epstein-Barr virus (EBV) status in a large cohort of gastric cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 4053-4053
Author(s):  
Akihito Kawazoe ◽  
Takeshi Kuwata ◽  
Yasutoshi Kuboki ◽  
Kohei Shitara ◽  
Akiko Nagatsuma ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mismatch Repair ◽  
Epstein Barr Virus ◽  
Tumor Infiltrating Lymphocytes ◽  
Clinicopathological Features ◽  
Large Cohort ◽  
Barr Virus ◽  
Epstein Barr ◽  
Infiltrating Lymphocytes ◽  
Program Death Ligand

Prognostic value of tumor infiltrating lymphocytes in Epstein-Barr virus-associated gastric cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 4062-4062
Author(s):  
Shinkyo Yoon ◽  
Soo Jung Lee ◽  
Yee Soo Chae ◽  
Byung Wook Kang ◽  
Jong Gwang Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Tumor Infiltrating Lymphocytes ◽  
Barr Virus ◽  
Epstein Barr ◽  
Infiltrating Lymphocytes

Clinicopathological features of program death ligand-1 expression with mismatch repair, Epstein-Barr virus status, and cancer genome alterations in metastatic gastric cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 4040-4040 ◽  
Author(s):  
Akihito Kawazoe ◽  
Kohei Shitara ◽  
Yasutoshi Kuboki ◽  
Hideaki Bando ◽  
Takashi Kojima ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mismatch Repair ◽  
Epstein Barr Virus ◽  
Metastatic Gastric Cancer ◽  
Cancer Genome ◽  
Clinicopathological Features ◽  
Barr Virus ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Epstein Barr

4040 Background: Recently, anti-programmed death 1 (PD-1) or its ligand (PD-L1) antibodies have shown promising activities in metastatic gastric cancer (MGC). However, little is known about detailed clinicopathological features of PD-L1 expression in patients (pts) with MGC. Methods: Pts with histologically confirmed MGC were eligible for this prospective observational study. PD-L1 expression on tumor cell (TC) or inflammatory cell (IC) and mismatch repair (MMR) were analyzed by immunohistochemistry (IHC). Epstein–Barr virus (EBV) was detected by in situ hybridization. The expressions of tyrosine kinase receptors (RTKs) such as HER2, EGFR and MET and cancer genome alterations were also evaluated by IHC or next generation sequencing. Results: A total of 237 pts were enrolled from September 2015 to December 2016. Samples of 199 (84.0%) pts were obtained from biopsy. PD-L1 expression on TC and IC was positive in 27 (11.4%) and 167 pts (70.5%), respectively. One hundred and seventy-one pts (72.2%) had positive PD-L1 expression on either TC or IC. MMR deficient (D-MMR) and EBV was detected in 14 (6.9%, n = 203) and 14 pts (5.9%, n = 237), respectively. PD-L1 expression on TC was more frequently observed in pts with D-MMR (P < 0.001) and KRAS mutation (P < 0.001), while that on IC was more frequently observed in pts with EBV+ (P = 0.045), lymph node metastasis (P = 0.001), and lung metastasis (P = 0.045). In contrast, pts with peritoneal metastasis were associated with less frequent PD-L1 expression in IC (P = 0.003). A significant association was not observed between PD-L1 expression and RTKs expression or presence of other gene alterations. D-MMR was significantly associated with intestinal type (P = 0.026) and absence of liver metastasis (P = 0.022). PD-L1 expression on either TC or IC was not prognostic factor (hazard ratio; 0.92, P = 0.741). Seven pts with D-MMR and seven pts with EBV+ MGC were enrolled in clinical trials of anti-PD-1/PD-L1 antibodies. Conclusions: PD-L1 expression in MGC was associated with some clinicopathological features. Impact of these characteristics on efficacy of anti-PD-1/PD-L1 antibody warrants further evaluation.

scholarly journals Prognostic Value of Tumor-Infiltrating Lymphocytes and Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated and -Negative Gastric Carcinoma

2021 ◽  
Vol 12 ◽  
Author(s):  
Na Cheng ◽  
Peng Li ◽  
Huanhuan Cheng ◽  
Xiaoxiao Zhao ◽  
Min Dong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Tumor Infiltrating Lymphocytes ◽  
Barr Virus ◽  
Tertiary Lymphoid Structures ◽  
Epstein Barr ◽  
Lymphoid Structures ◽  
Infiltrating Lymphocytes

BackgroundTumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response against cancer and tertiary lymphoid structures (TLS) may contribute to lymphocytes recruitment. Both of them have been reported as potential prognostic parameters in some human malignancies. However, the roles of TILs, TLS, and their correlation in Epstein-Barr Virus-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) are largely unknown.MethodsTo observe the correlation among TILs, TLS, and clinicopathological characteristics and their prognostic significance in EBVaGC and EBVnGC, respectively. TILs and TLS were assessed by morphology and/or immunohistochemistry, and accompanied by clinicopathological analysis from 846 gastric cancer patients in multiple institutions.ResultsForty-two (5.0%) cases of EBVaGC and 804 cases of EBVnGC were identified by in situ hybridization, respectively. For EBVnGC, higher TILs grade was correlated with TLS-present. EBVnGC patients with high TILs grade and TLS-present exhibited survival benefits. TILs (P = 0.001) and TLS (P = 0.003), especially TILs &amp; TLS (P &lt; 0.001) were independent prognostic factors in EBVnGC. A nomogram was constructed and validated for predicting the probability of overall survival and performed well with a good calibration. No significant prognostic value was detected in EBVaGC.ConclusionTILs and TLS, especially TILs &amp; TLS were promising prognostic indicators for overall survival in EBVnGC. TILs and TLS were highly overlapping in their extent and prognostic abilities, and may be considered as a coindicator of prognosis of gastric cancer. The evaluations of TILs and TLS are simple and can be assessed routinely in pathological diagnosis.

scholarly journals Prognostic value of tumor-infiltrating lymphocytes in Epstein–Barr virus-associated gastric cancer

2016 ◽  
Vol 27 (3) ◽  
pp. 494-501 ◽  
Author(s):  
B.W. Kang ◽  
A.N. Seo ◽  
S. Yoon ◽  
H.I. Bae ◽  
S.W. Jeon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Epstein Barr Virus ◽  
Tumor Infiltrating Lymphocytes ◽  
Barr Virus ◽  
Epstein Barr ◽  
Infiltrating Lymphocytes

Presence of Epstein-Barr virus in esophageal cancer is restricted to tumor infiltrating lymphocytes

2005 ◽  
Vol 194 (4) ◽  
pp. 187-191 ◽  
Author(s):  
Sabine Awerkiew ◽  
Axel zur Hausen ◽  
Stephan E. Baldus ◽  
Arnulf H. Hölscher ◽  
Svetlana I. Sidorenko ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Epstein Barr Virus ◽  
Tumor Infiltrating Lymphocytes ◽  
Barr Virus ◽  
Epstein Barr ◽  
Infiltrating Lymphocytes

scholarly journals Prevalence of Helicobacter pylori Infection, Its Virulent Genotypes, and Epstein-Barr Virus in Peruvian Patients With Chronic Gastritis and Gastric Cancer

2019 ◽  
pp. 1-9 ◽  
Author(s):  
Carlos A. Castaneda ◽  
Miluska Castillo ◽  
Iván Chavez ◽  
Fernando Barreda ◽  
Nancy Suarez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Chronic Gastritis ◽  
Epstein Barr Virus ◽  
Quantitative Polymerase Chain Reaction ◽  
Geographic Location ◽  
Clinicopathological Features ◽  
Barr Virus ◽  
Virulent Strains ◽  
Epstein Barr

PURPOSE Helicobacter pylori (HP) and Epstein Barr virus (EBV) infections induce chronic gastritis (CG) and are accepted carcinogenics of gastric cancer (GC). Our objective for this study was to determine the prevalence of these agents and clinicopathological features of GC and CG associated with the infection. PATIENTS AND METHODS A single-center cohort of 375 Peruvian patients with GC and 165 control subjects with CG were analyzed. Evaluation of HP and EBV genes was performed through quantitative polymerase chain reaction. RESULTS Prevalence of HP was 62.9% in the whole population and 60.8% in the GC subset. The cagA gene was detected in 79.9%; vacAs1 and vacAm1 alleles in 41.6% and 60.7%, respectively; and concurrent expression of vacAs1 and vacAm1 in 30.4% of infected patients in the whole series. The prevalence of EBV was 14.1% in the whole population and was higher in GC ( P < .001). Coinfection of HP and EBV was found in 7.8% and was also higher in GC in univariate ( P < .001) and multivariate ( P = .011) analyses. Infection rates of HP and EBV were not associated with a geographic location in the whole series. Few clinicopathological features have been associated with infectious status. CONCLUSION Prevalence of HP infection and virulent strains are high in the Peruvian population. Infection by EBV was more frequent in patients with GC.

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