Snake Venom Matrix Metalloproteinases (svMMPs)

2021 ◽  
pp. 381-388
Author(s):  
Inácio L. M. Junqueira-de-Azevedo ◽  
Juan David Bayona-Serrano
Keyword(s):  
Matrix Metalloproteinases ◽  
Snake Venom

COMPARISON OF SNAKE VENOM REPROLYSIN AND MATRIX METALLOPROTEINASES AS MODELS OF TNF-α CONVERTING ENZYME

1997 ◽  
Vol 7 (10) ◽  
pp. 1219-1224 ◽  
Author(s):  
Drew E Van Dyk ◽  
Petra Marchand ◽  
Robert C Bruckner ◽  
Jay W Fox ◽  
Bruce D Jaffee ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Snake Venom ◽  
Converting Enzyme ◽  
Tnf Α

Snake venom matrix metalloproteinases: A new major class of proteolytic toxins across dipsadidae

Toxicon ◽  
2020 ◽  
Vol 177 ◽  
pp. S55
Author(s):  
Juan David Bayona Serrano ◽  
Pollyanna Fernandes Campos ◽  
Luciana Aparecida Freitas de Sousa ◽  
Ursula Castro de Oliveira ◽  
Débora Andrade Silva ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Snake Venom ◽  
Major Class

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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