Cerebellar Stimulation for Spasticity and Seizures

In cats anesthetized with chloralose-urethane mixture, stimulation of an afferent nerve evoked a vasoconstrictor reflex (VCR) and a galvanic skin response (GSR) in the pads of the feet. Stimulation of the ventromedial medullary reticular substance at the level of the obex abolished the VCR and the GSR. VCR could also be reduced by occlusion during prolonged stimulation of another spinal or visceral afferent pathway. Medulla stimulation was effective without itself causing a sympathetic discharge to the paw, showing that inhibition rather than occlusion was operative. Anterior cerebellar stimulation also inhibited the VCR. Carotid sinus nerve stimulation did not abolish the VCR. It is concluded that the effective mechanism includes a bulbospinal inhibitory path projecting on a spinal vasoconstrictor reflex arc. This arrangement is similar to the descending pathways inhibiting other spinal reflexes but the VCR-inhibitory path can be activated independently of them.

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The critical need to develop tools assessing cerebellar reserve for the delivery and assessment of non-invasive cerebellar stimulation

Cerebellum & Ataxias ◽

10.1186/s40673-020-00126-w ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Mario Manto ◽

Shinji Kakei ◽

Hiroshi Mitoma

Keyword(s):

Daily Practice ◽

Clinical Applications ◽

Non Invasive ◽

Very High ◽

Cerebellar Disorders ◽

Cerebellar Stimulation

AbstractNon-invasive cerebellar stimulation (NICS) aims to modulate cerebello-cerebral loops and cerebro-spinal loops, both for research and clinical applications. It is of paramount importance to establish and validate morphological and functional tools to quantify cerebellar reserve, defined as the capacity for restoration and compensation to pathology of the cerebellum. Using NICS without efforts to estimate cerebellar reserve will end up in conflicting results due to the very high heterogeneity of cerebellar disorders encountered in daily practice.

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Deep anterior cerebellar stimulation reduces symptoms of secondary dystonia in patients with cerebral palsy treated due to spasticity

Clinical Neurology and Neurosurgery ◽

10.1016/j.clineuro.2015.05.017 ◽

2015 ◽

Vol 135 ◽

pp. 62-68 ◽

Cited By ~ 25

Author(s):

Paweł Sokal ◽

Marcin Rudaś ◽

Marek Harat ◽

Łukasz Szylberg ◽

Piotr Zieliński

Keyword(s):

Cerebral Palsy ◽

Secondary Dystonia ◽

Cerebellar Stimulation

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Chronic cerebellar stimulation and developmental reflexes

Journal of Neurosurgery ◽

10.3171/jns.1977.46.4.0506 ◽

1977 ◽

Vol 46 (4) ◽

pp. 506-511 ◽

Cited By ~ 21

Author(s):

Richard D. Penn ◽

Mary Liz Etzel

Keyword(s):

Cerebral Palsy ◽

Anterior Lobe ◽

Chronic Stimulation ◽

Content Type ◽

Motor Disabilities ◽

Primitive Reflexes ◽

Developmental Scale ◽

Motor Retardation ◽

Fine Print ◽

Cerebellar Stimulation

✓ The changes in motor function in cerebral palsy patients produced by chronic anterior lobe cerebellar stimulation were documented with the Milani-Comparetti developmental scale, which allows comparison between functional gains and reflex patterns. Two patients with marked motor retardation and primitive reflexes were followed serially over several months of stimulation. Using these measures, the efficiency of chronic stimulation can be assessed, although many years will be needed to evaluate its role in treating motor disabilities.

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