Systems Approaches to Achieving Quarantine Security

Author(s):  
Eric B. Jang ◽  
Harold R. Moffitt
Keyword(s):  
1971 ◽  
Author(s):  
Frank Baker ◽  
Nolan Penn ◽  
Dwight Harshbarger ◽  
Henry Wechsler ◽  
Denise Thum ◽  
...  
Keyword(s):  

2017 ◽  
Vol 23 (32) ◽  
pp. 4773-4793 ◽  
Author(s):  
Nivedita Singh ◽  
Sherry Freiesleben ◽  
Olaf Wolkenhauer ◽  
Yogeshwer Shukla ◽  
Shailendra K. Gupta

The identification and validation of novel drug–target combinations are key steps in the drug discovery processes. Cancer is a complex disease that involves several genetic and environmental factors. High-throughput omics technologies are now widely available, however the integration of multi-omics data to identify viable anticancer drug-target combinations, that allow for a better clinical outcome when considering the efficacy-toxicity spectrum, is challenging. This review article provides an overview of systems approaches which help to integrate a broad spectrum of technologies and data. We focus on network approaches and investigate anticancer mechanism and biological targets of resveratrol using reverse pharmacophore mapping as an in-depth case study. The results of this case study demonstrate the use of systems approaches for a better understanding of the behavior of small molecule inhibitors in receptor binding sites. The presented network analysis approach helps in formulating hypotheses and provides mechanistic insights of resveratrol in neoplastic transformations.


2011 ◽  
Vol 10 (5) ◽  
pp. 266-279 ◽  
Author(s):  
T. Pfau ◽  
N. Christian ◽  
O. Ebenhoh
Keyword(s):  

2020 ◽  
Vol 37 (4) ◽  
pp. 214-233 ◽  
Author(s):  
Jennifer Whyte ◽  
Ana Mijic ◽  
Rupert J. Myers ◽  
Panagiotis Angeloudis ◽  
Michel-Alexandre Cardin ◽  
...  

2008 ◽  
Vol 45 (4) ◽  
pp. 567-581 ◽  
Author(s):  
Thomas E. Robey ◽  
Mark K. Saiget ◽  
Hans Reinecke ◽  
Charles E. Murry

2012 ◽  
Vol 367 (1599) ◽  
pp. 2108-2118 ◽  
Author(s):  
Louise Barrett ◽  
S. Peter Henzi ◽  
David Lusseau

Understanding human cognitive evolution, and that of the other primates, means taking sociality very seriously. For humans, this requires the recognition of the sociocultural and historical means by which human minds and selves are constructed, and how this gives rise to the reflexivity and ability to respond to novelty that characterize our species. For other, non-linguistic, primates we can answer some interesting questions by viewing social life as a feedback process, drawing on cybernetics and systems approaches and using social network neo-theory to test these ideas. Specifically, we show how social networks can be formalized as multi-dimensional objects, and use entropy measures to assess how networks respond to perturbation. We use simulations and natural ‘knock-outs’ in a free-ranging baboon troop to demonstrate that changes in interactions after social perturbations lead to a more certain social network, in which the outcomes of interactions are easier for members to predict. This new formalization of social networks provides a framework within which to predict network dynamics and evolution, helps us highlight how human and non-human social networks differ and has implications for theories of cognitive evolution.


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