Enzyme and Cofactor Engineering

2018 ◽  
pp. 167-186
Author(s):  
George N. Bennett ◽  
Ka-Yiu San
Keyword(s):  
Cofactor Engineering

scholarly journals Manipulation of the ATP pool as a tool for metabolic engineering

2015 ◽  
Vol 43 (6) ◽  
pp. 1140-1145 ◽  
Author(s):  
Oliver Hädicke ◽  
Steffen Klamt
Keyword(s):  
Metabolic Engineering ◽  
Product Yield ◽  
Volumetric Productivity ◽  
Special Focus ◽  
Process Performance ◽  
Performance Parameters ◽  
Cofactor Engineering ◽  
Atp Pool ◽  
Fine Tune

Cofactor engineering has been long identified as a valuable tool for metabolic engineering. Besides interventions targeting the pools of redox cofactors, many studies addressed the adenosine pools of microorganisms. In this mini-review, we discuss interventions that manipulate the availability of ATP with a special focus on ATP wasting strategies. We discuss the importance to fine-tune the ATP yield along a production pathway to balance process performance parameters like product yield and volumetric productivity.

Redirecting metabolic fluxes through cofactor engineering: Role of CoA-esters pool during l(−)-carnitine production by Escherichia coli

2007 ◽  
Vol 132 (2) ◽  
pp. 110-117 ◽  
Author(s):  
Vicente Bernal ◽  
Beatriz Masdemont ◽  
Paula Arense ◽  
Manuel Cánovas ◽  
José Luis Iborra
Keyword(s):  
Escherichia Coli ◽  
Cofactor Engineering ◽  
Metabolic Fluxes

scholarly journals Cofactor engineering improved CALB production in Pichia pastoris through heterologous expression of NADH oxidase and adenylate kinase

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181370 ◽  
Author(s):  
Charumathi Jayachandran ◽  
Balakumaran Palanisamy Athiyaman ◽  
Meenakshisundaram Sankaranarayanan
Keyword(s):  
Pichia Pastoris ◽  
Heterologous Expression ◽  
Adenylate Kinase ◽  
Nadh Oxidase ◽  
Cofactor Engineering

A new approach for efficient synthesis of phenyllactic acid from L-phenylalanine: Pathway design and cofactor engineering

2018 ◽  
Vol 42 (5) ◽  
pp. e12584 ◽  
Author(s):  
Xiuting Wang ◽  
Ying Hou ◽  
Long Liu ◽  
Jianghua Li ◽  
Guocheng Du ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Cofactor Engineering ◽  
Phenyllactic Acid ◽  
New Approach
Sign in / Sign up

Export Citation Format

Share Document