Comparative Kidney Carcinogenesis in Laboratory Rodents and Humans

2021 ◽  
pp. 439-466
Author(s):  
Gordon C. Hard
Keyword(s):  
Laboratory Rodents

scholarly journals Can the Hole–Board Test Predict a Rat’s Exploratory Behavior in a Free-Exploration Test?

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1068
Author(s):  
Wojciech Pisula ◽  
Klaudia Modlinska ◽  
Katarzyna Goncikowska ◽  
Anna Chrzanowska
Keyword(s):  
Exploratory Behavior ◽  
Predictive Value ◽  
Previous Experience ◽  
General Hypothesis ◽  
Free Exploration ◽  
Laboratory Rodents ◽  
Board Test ◽  
Motivational Mechanism ◽  
Hole Board ◽  
Hole Board Test

This study focuses on the rat activity in a hole–board setting that we considered a type of exploratory behavior. The general hypothesis is based on the claim that a motivational mechanism is central to both the response to novelty in a highly familiarized environment and the activity in the hole–board apparatus. Our sample consisted of 80 experimentally naive Lister Hooded rats. All rats were tested in the hole–board apparatus. Twenty individuals with the highest hole-board scores and twenty subjects with the lowest hole–board scores subsequently underwent an established free-exploration test. In our study, the scores obtained in the hole–board test had little predictive value for the rats’ activity in the free-exploration test. Based on our previous experience in studying exploratory behavior in the free-exploration test and the data presented in this paper, we suggest that the hole–board test is not an appropriate tool for measuring exploratory behavior in laboratory rodents.

An improved, portable machine designed to induce and maintain surgical anaesthesia in small laboratory rodents

1982 ◽  
Vol 16 (3) ◽  
pp. 227-230 ◽  
Author(s):  
M. L. Norris ◽  
P. Miles
Keyword(s):  
Mongolian Gerbils ◽  
Small Laboratory ◽  
Golden Hamsters ◽  
Laboratory Rodents

The machine was successfully used to induce and maintain anaesthesia by inhalation of methoxyflurane in Mongolian gerbils, mice and golden hamsters.

scholarly journals Frequent serial fecal corticoid measures from rats reflect circadian and ovarian corticosterone rhythms

2005 ◽  
Vol 184 (1) ◽  
pp. 153-163 ◽  
Author(s):  
S A Cavigelli ◽  
S L Monfort ◽  
T K Whitney ◽  
Y S Mechref ◽  
M Novotny ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Temporal Acuity ◽  
Non Invasive ◽  
Laboratory Rodents ◽  
Sprague Dawley Rats ◽  
Single Animal ◽  
Invasive Method ◽  
Luteinizing Hormone Surge ◽  
Corticosterone Metabolites ◽  
Fecal Corticosterone Metabolites

The circadian glucocorticoid rhythm provides important information on the functioning of the hypothalamic-pituitary-adrenal axis in individuals. Frequent repeated blood sampling can limit the kinds of studies conducted on this rhythm, particularly in small laboratory rodents that have limited blood volumes and are easily stressed by handling. We developed an extraction and assay protocol to measure fecal corticosterone metabolites in repeated samples collected from undisturbed male and female adult Sprague–Dawley rats. This fecal measure provides a non-invasive method to assess changes in corticosterone within a single animal over time, with sufficient temporal acuity to quantify several characteristics of the circadian rhythm: e.g. the nadir, acrophase, and asymmetry (saw-tooth) of the rhythm. Males excreted more immunoreactive fecal corticoids than did females. Across the estrous cycle, females produced more fecal corticoids on proestrus (the day of the preovulatory luteinizing hormone surge) than during estrus or metestrus. These results establish a baseline from which to study environmental, psychological, and physiological disturbances of the circadian corticosterone rhythm within individual rats.

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