Post-activation Performance Enhancement after a Bout of Accentuated Eccentric Loading in Collegiate Male Volleyball Players

The purpose of this study was to investigate the benefit of post-activation performance enhancement (PAPE) after accentuated eccentric loading (AEL) compared to traditional resistance loading (TR). Sixteen male volleyball athletes were divided in AEL and TR group. AEL group performed 3 sets of 4 repetitions (eccentric: 105% of concentric 1RM, concentric: 80% of concentric 1RM) of half squat, and TR group performed 3 sets of 5 repetitions (eccentric & concentric: 85% of 1RM). Countermovement jump (CMJ), spike jump (SPJ), isometric mid-thigh pull (IMTP), and muscle soreness test were administered before (Pre) exercise, and 10 min (10-min), 24 h (24-h), and 48 h (48-h) after exercise. A two-way repeated measures analysis of variance was used to analyze the data. Peak force and rate of development (RFD) of IMTP in AEL group were significantly greater (p < 0.05) than TR group. The height, peak velocity, and RFD of CMJ, height of SPJ, and muscle soreness showed no interaction effects (p > 0.05) groups x time. AEL seemed capable to maintain force production in IMTP, but not in CMJ and SPJ. It is recommended the use of accentuated eccentric loading protocols to overcome the fatigue.

Risk factors for the progression of trachomatous scarring in a cohort of women in a trachoma low endemic district in Tanzania

Background Trachoma, a chronic conjunctivitis caused by Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. Trachoma has been targeted for elimination as a public health problem which includes reducing trachomatous inflammation—follicular prevalence in children and reducing trachomatous trichiasis prevalence in adults. The rate of development of trachomatous trichiasis, the potentially blinding late-stage trachoma sequelae, depends on the rate of trachomatous scarring development and progression. Few studies to date have evaluated the progression of trachomatous scarring in communities that have recently transitioned to a low trachomatous inflammation—follicular prevalence. Methodology/Principal findings Women aged 15 and older were randomly selected from households in 48 communities within Kongwa district, Tanzania and followed over 3.5 years for this longitudinal study. Trachomatous inflammation—follicular prevalence was 5% at baseline and at follow-up in children aged 1–9 in Kongwa, Tanzania. 1018 women aged 15 and older had trachomatous scarring at baseline and were at risk for trachomatous scarring progression; 691 (68%) completed follow-up assessments. Photographs of the upper tarsal conjunctiva were obtained at baseline and follow-up and graded for trachomatous scarring using a previously published four-step severity scale. The overall cumulative 3.5-year progression rate of scarring was 35.3% (95% CI 31.6–39.1). The odds of TS progression increased with an increase in age in women younger than 50, (OR 1.03, 95% CI 1.01–1.05, p = 0.005) as well as an increase in the household poverty index (OR 1.29, 95% CI 1.13–1.48, p = 0.0002). Conclusions/Significance The 3.5-year progression of scarring among women in Kongwa, a formerly hyperendemic now turned hypoendemic district in central Tanzania, was high despite a low active trachoma prevalence. This suggests that the drivers of scarring progression are likely not related to on-going trachoma transmission in this district.

Ramularia leaf spot in barley

Ramularia leaf spot is an emerging pathogen across barley growing regions of the world. It's rise from minor to major disease has been rapid over the last twenty years. The causal pathogen, Ramularia collo-cygni is poorly understood but it has been shown to have a complex life cycle and the ability to exist on many hosts in an endophytic state. The rate of development of fungicide resistance in the fungus is also extremely fast and many of the major single site fungicides are no longer effective in many countries. With multisite fungicides having their approval or reconsidered and no consistent varietal resistance available, control of the disease is increasing challenging. This chapter reviews the latest research into Ramularia biology and control and highlights the areas where recent advances have been made.

ANALYSIS OF DEVELOPING RAW MATERIALS IN NORTH KURIL ZONE OF FAR EASTERN FISHERIES IN 2010–2019

The article presents the analysis of the development of commercial objects in the North-Kuril zone of the Far Eastern fisheries basin for a ten-year period. The resource potential of this zone was found to consist of 11 objects for which the total allowable catches were established (TAC objects) and of 4 objects, the extraction of which is carried out within the recommended volumes (non-TAC objects). The main objects of production in the North-Kuril zone were pollock, Commander squid and terpug, the production volumes of each species, in the total catch of all objects, amounted to 48, 26 and 13%, respectively. The production volumes of the rest commercial objects amounted to a total of about 13%. An analysis of the dynamics of changes in the TACs was carried out for each test fishing object. A decrease of catch volumes in 2019, compared to 2010, was observed in three objects: terpugs, halibut and macrurus. For these objects during the period under review there was found a decrease in TAC volumes. Analysis of the development of the objects under study during the period 2010-2019 showed that crabs, scallops and pollock in the studied time interval had consistently high catch volumes and a high degree of development. The average rate of development of these objects was about 90% or more. The remaining 8 fishing objects were under-developed annually. The average degree of development of Far Eastern flounder, Commander squid, terpug, cod, sea bass was about 55-75%. The lowest average rate of development (less than 50%) was observed in halibut, pinchback and macrurus. It has been inferred that it is necessary to conduct further studies of fishing activities to develop the resource potential for subsequent modeling and optimization of fishing processes

Astrocytes and their Phenomenal Possibilities in the Treatment of Various Neurodegenerative Disorders: An Overview

At present, research in the field of the brain does not cease to surprise us with new facts and discoveries that no one could have suspected about 30 years ago. But it was at the time when it became clear that the cerebral neurons are not the only cells that can respond to changes in the external environment. A real scientific boom began to study a heterogeneous group called glia. And scientists are paying close attention to the largest of them – astrocytes. Understanding the importance of astrocytes in the mechanisms of repair and damage to brain cells in various forms of CNS pathology determines the possibility of targeted search for drugs that affect the rate of development of reactive astrogliosis in response to various brain injuries. At the same time, pharmacological modulation of activated astrocytes and other components of glia can be an integral part of the therapy of neurological diseases.

POS0111 DEVELOPMENT OF DAMAGE AND MORTALITY IN AN INCEPTION COHORT OF SLE PATIENTS

Background:There had been very limited data on the development of damage and mortality in an inception cohort of SLE patients who were recruited very soon after diagnosis.Objectives:This study aimed to analyse the development of damage and death in an inception cohort of SLE patients recruited within 1 year of diagnosis with up to 13 years of follow-up.Methods:This was a prospective multi-centre longitudinal study in the UK of SLE patients recruited within 12 months of achieving 1997 ACR revised criteria for SLE. Data were collected on BILAG-2004, BILAG2004-Pregnancy Index (during pregnancy), SLICC/ACR DI (SDI), cumulative drug exposure and death at every visit. Information on cardiovascular risk factors and antiphospholipid syndrome status were also collected. This study ran from 1st January 2005 to 31st December 2017. Mortality and development of damage were analysed.Results:There were 273 patients recruited (91.2% female, 59.3% Caucasian, 17.2% African/Caribbean, 17.2% South Asian) with mean age at recruitment of 38.5 years (SD 14.8). 97.8% had no damage at recruitment (2.2% had SDI score of 1). Median follow-up was 73.4 months (range: 1.8, 153.8) with total follow-up of 1767 patient-years.There were 13 deaths (4.8%): 76.9% female, 84.6% Caucasian, 15.4% South Asian, mean age 62.6 years (± SD 15.8) and mean disease duration 3 years (± SD 1.8). Causes of death were cancer in 5 (38.5%), infection in 3 (23.1%), ischaemic heart disease in 1 (7.7%) and unknown in 4 (30.8%).114 new damage items in 83 patients occurred during follow-up. The distribution of damage was musculoskeletal (21, 18.4%), ophthalmic (18, 15.8%), neuropsychiatric (18, 15.8%), renal (14, 12.3%), malignancy (12, 10.5%), cutaneous (7, 6.1%), GIT (7, 6.1%), cardiac (6, 5.3%), pulmonary (4, 3.5%), diabetes mellitus (4, 3.5%) and vascular (3, 2.6%). The rate of development of damage appears to be higher in the first 3 years which subsequently stabilised (Table 1).Table 1.Incidence rate of development of damage over period of follow-up at 3 yearly intervalsPeriod of follow-up (year)Person-years at riskNumber of new items of damageIncidence rate, per 1000 person-years (95% CI)0 – 3753.46079.6 (61.8, 102.6)3 – 6534.03158.1 (40.8, 82.6)6 – 9321.21237.4 (21.2, 35.8)9 – 12152.5532.8 (13.6, 78.7)> 125.90-Conclusion:Mortality is uncommon during the first 12 years of follow-up for newly diagnosed SLE patients. However, development of damage appears to be higher in the first 3 years before stabilizing to a lower rate subsequently.Acknowledgements:Versus Arthritis, VIfor PharmaDisclosure of Interests:Chee-Seng Yee Consultant of: Bristol Myer Squibb, ImmuPharma, Grant/research support from: Vifor Pharma, Vernon Farewell: None declared, Mohammed Akil: None declared, Peter Lanyon: None declared, Christopher John Edwards Consultant of: Glaxo Smith Kline, Roche, Grant/research support from: Glaxo Smith Kline, Roche, David Isenberg: None declared, Anisur Rahman: None declared, Lee-Suan Teh: None declared, Sofia Tosounidou: None declared, Robert Stevens: None declared, Ahtiveer Prabu: None declared, Bridget Griffiths: None declared, Neil McHugh: None declared, Ian N. Bruce: None declared, Yasmeen Ahmad: None declared, Munther Khamashta: None declared, Caroline Gordon Speakers bureau: UCB, Consultant of: Center for Disease Control, Astra-Zeneca, MGP, Sanofi and UCB

TranSyT, the Transport Systems Tracker

The importance and rate of development of GSM models have been growing for the last years, increasing the demand for software solutions that automatise several steps of this process. However, since TRIAGE's release, software development for automatic integration of transport reactions into models has stalled. Here we present the Transport Systems Tracker (TranSyT), the next iteration of TRIAGE. Unlike its predecessor, TranSyT does not rely on manual curation to expand its internal database, derived from highly-curated records retrieved from TCDB and complemented with information from other data sources. TranSyT compiles information regarding TC families, transport proteins, and derives reactions into its internal database, making it available for rapid annotation of complete genomes. All transport reactions have GPR associations and can be exported with identifiers from four different metabolite databases. TranSyT is currently available as a plugin for merlin v4.0 and an app for KBase.

DIGITALIZATION OF THE ECONOMY DURING A PANDEMIC: ACCELERATING THE RATE OF DEVELOPMENT

The spread of COVID-19 contributes to changing economic and social life in many countries. One of the most striking consequences of the current pandemic can already be called the accelerated introduction of digital technologies in a variety of areas. This article is devoted to the issues ofdigitalization of the economy of both countries and the world as a whole in the context of the coronavirus pandemic. Changes in the development trends of the digital technology market in China were analyzed.

Rhyzopertha dominica (lesser grain borer).

Females of R. dominica lay between 200 and 500 eggs in their lifetime. The eggs are laid loose in grain. The lowest temperature at which R. dominica can complete development is 20°C; at this temperature, the development from egg to adult takes 90 days. The fastest rate of development occurs at 34°C; at this temperature the egg takes 2 days, the larvae 17 days, and the pupae 3 days to complete development. R. dominica is unable to complete development between 38 and 40°C. Adults live for 4-8 months. Under optimal conditions of 34°C and 14% grain moisture content, there is a 20-fold increase in the population of R. dominica after 4 weeks. It can successfully infest grain at 9% moisture content, but has higher fecundity, a faster rate of development, and lower mortality on grain of a higher moisture content. Adult males produce an aggregation pheromone in the frass that attracts both male and female adults. Adults are good flyers, and can be trapped in pheromone-baited flight traps placed several kilometres from grain stores. Adults can bore into intact kernels. The larvae of R. dominica are mobile.