Letter to the Editor: Is Cystic Fibrosis Protein a Diagnostic Marker for Individuals Who Harbor the Defective Gene?

Many physicians do not accept the hypothesis put forward in Dr. Chadwick's letter but rather they still accept the statement by the Committee on Therapy regarding the treatment of cystic fibrosis. This document states, "the aim of nebulization therapy in cystic fibrosis is to deposit particles of water or water-containing medication in the bronchial tree at the site of the disease process" and further goes on to state "nebulization or aerosol therapy must not be confused with humidification."

Download Full-text

Letter to the Editor

PEDIATRICS ◽

10.1542/peds.43.5.905b ◽

1969 ◽

Vol 43 (5) ◽

pp. 905-906

Author(s):

Aubrey Milunsky

Keyword(s):

Cystic Fibrosis ◽

Bone Marrow ◽

Clinical Presentation ◽

Pancreatic Insufficiency ◽

Chloride Concentration ◽

Letter To The Editor ◽

Patient Reported ◽

Sweat Sample ◽

Chloride Concentrations

The patient reported in the foregoing letter is of particular interest in view of the recent observations on patients with tnisomy 21 and cystic fibrosis. The multiple possibilities that could explain the clinical presentation have no doubt been considered by the authors. However, the description of "hypoplastic thrombocytopenia" and later pancytopenia in this patient, associated with pancreatic insufficiency, leads to the serious consideration of Shwachman's syndrome (pancreatic insufficiency and bone marrow dysfunction). The wide discrepancy between the sodium and chloride concentrations in the sweat reported in their letter indicates that evaporation of water may have occurred from the sweat sample, leading to an apparently higher sodium and chloride concentration.

Download Full-text

SURFACTANT PROTEIN A IN BRONCHOALVEOLAR LAVAGE FLUID OF CHILDREN WITH CYSTIC FIBROSIS

Critical Care Medicine ◽

10.1097/00003246-200412001-00412 ◽

2004 ◽

Vol 32 (Supplement) ◽

pp. A115

Author(s):

Neal J Thomas ◽

Gavin R Graff ◽

Todd M Umstead ◽

David S Phelps ◽

Joanna Floros

Keyword(s):

Cystic Fibrosis ◽

Bronchoalveolar Lavage ◽

Bronchoalveolar Lavage Fluid ◽

Protein A ◽

Lavage Fluid ◽

Surfactant Protein ◽

Surfactant Protein A

Download Full-text

Adenosine deaminase binding protein, a new diagnostic marker for kidney disease.

Clinical Chemistry ◽

10.1093/clinchem/31.5.679 ◽

1985 ◽

Vol 31 (5) ◽

pp. 679-683 ◽

Cited By ~ 20

Author(s):

R E Thompson ◽

D J Piper ◽

C Galberg ◽

T H Chan ◽

N E Tolkoff-Rubin ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Kidney Disease ◽

Adenosine Deaminase ◽

Allograft Rejection ◽

Renal Allograft ◽

Diagnostic Marker ◽

Binding Protein ◽

Protein A ◽

Standard Curve ◽

Transplant Patients

Abstract This enzyme immunoassay detects adenosine deaminase binding protein (ABP), a glycoprotein that is shed from the brush border of the proximal tubule in kidney damage. Two monoclonal antibodies, URO-4 and URO-4a, each react with different epitopes on ABP and are used as the "sandwich" pair of antibodies. A linear standard curve can be generated by using partly purified ABP isolated from the urine of patients with kidney disease. Release of ABP into the urine appears to reflect the severity of the insult to the nephron. Therefore, measurement of ABP in urine may help distinguish between tubular disease and glomerular disease and indicate renal allograft rejection in renal-transplant patients.

Download Full-text