scholarly journals 882 INTERFERON GAMMA MODULATES PROTEIN KINASE C IN MURINE PERITONEAL MACROPHAGES

1985 ◽  
Vol 19 (4) ◽  
pp. 257A-257A
Author(s):  
P L Becton ◽  
T A Hamilton ◽  
S D Somers ◽  
J M Falletta ◽  
D O Adams
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Interferon Gamma ◽  
Peritoneal Macrophages ◽  
Kinase C ◽  
Murine Peritoneal Macrophages

Swainsonine Modulation of Protein Kinase C Activity in Murine Peritoneal Macrophages

1990 ◽  
Vol 2 (10) ◽  
pp. 333-338 ◽  
Author(s):  
Pascal Breton ◽  
Amha Asseffa ◽  
Krzysztof Grzegorzewski ◽  
Steven K. Akiyama ◽  
Sandra L. White ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Peritoneal Macrophages ◽  
Kinase C ◽  
Protein Kinase C Activity ◽  
Murine Peritoneal Macrophages

Protein kinase C activation accelerates proton extrusion by vacuolar-type H+ -ATPases in murine peritoneal macrophages

FEBS Letters ◽  
1994 ◽  
Vol 350 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Tommy Nordström ◽  
Sergio Grinstein ◽  
Guy F. Brisseau ◽  
Morris F. Manolson ◽  
Ori D. Rotstein
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Peritoneal Macrophages ◽  
Proton Extrusion ◽  
Kinase C ◽  
Murine Peritoneal Macrophages ◽  
Protein Kinase C Activation

scholarly journals Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages

1989 ◽  
Vol 260 (2) ◽  
pp. 471-478 ◽  
Author(s):  
H J Pfannkuche ◽  
V Kaever ◽  
D Gemsa ◽  
K Resch
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Peritoneal Macrophages ◽  
Dependent Manner ◽  
Membrane Phospholipids ◽  
Dependent Protein Kinase ◽  
Kinase C ◽  
Dependent Protein ◽  
Dose Dependent ◽  
Mouse Peritoneal Macrophages

Resident mouse peritoneal macrophages synthesized and released prostaglandins (PGs) when challenged with 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1,2-dioctanoyl-sn-glycerol (DiC8). Both stimuli were found to activate Ca2+/phospholipid-dependent protein kinase C (PKC). 1-(5-Isoquinolinesulphonyl)-2-methylpiperazine (‘H-7’) and D-sphingosine, known to inhibit PKC by different mechanisms, were able to decrease the PKC activity of macrophages in a dose-dependent manner. Addition of either PKC inhibitor decreased PG synthesis and also the release of arachidonic acid (AA) from phospholipids induced by TPA or DiC8. Simultaneously TPA or DiC8 also decreased incorporation of free AA into membrane phospholipids of macrophages. AA incorporation could be restored, however, by pretreatment with the PKC inhibitors. Our results demonstrate an involvement of PKC in the regulation of PG synthesis in mouse peritoneal macrophages and provide further evidence that reacylation of released fatty acids may be an important regulatory step.

Sign in / Sign up

Export Citation Format

Share Document