scholarly journals THE ROLE OF ATRIAL NATRIURETIC PEPTIDE (ANP) IN CONGENITAL HEART DISEASE

1987 ◽  
Vol 21 (4) ◽  
pp. 189A-189A ◽  
Author(s):  
Alan L Davis ◽  
David S Goldstein ◽  
Stephen Shapiro ◽  
Murray M Pollack
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Atrial Natriuretic

THE ROLE OF ATRIAL NATRIURETIC PEPTIDE IN CONGENITAL HEART DISEASE

1987 ◽  
Vol 15 (4) ◽  
pp. 413
Author(s):  
Alan L. Davis ◽  
David S. Goldstein ◽  
Stephen Shapiro ◽  
Murray M. Pollack
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Atrial Natriuretic

Elevation of atrial natriuretic peptide prohormone. Hemodynamic background of the elevation of N-terminal natriuretic peptide prohormone in children with congenital heart disease

1999 ◽  
Vol 9 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Henrik Holmström ◽  
Christian Hall ◽  
Oddvar Stokke ◽  
Harald Lindberg ◽  
Erik Thaulow
Keyword(s):  
Heart Failure ◽  
Congenital Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Atrial Natriuretic Peptide ◽  
Likelihood Ratio ◽  
Natriuretic Peptide ◽  
Pulmonary Blood Flow ◽  
Congenital Heart ◽  
Atrial Natriuretic

AbstractWe postulated previously that variables related to pulmonary flow are independent predictors of levels of atrial natriuretic peptide in children with congenital heart disease. The aim of this study was to test this hypothesis in relation to other hemodynamic and clinical variables.During catheterization we measured the levels of plasma N-terminal atrial natriuretic peptide prohormone in the plasma of 68 children with congenital heart disease. All had undergone complete clinical, echocardiographic and invasive hemodynamic investigations. The influence on the prohormone was analyzed for 10 different variables in a multiple linear regression model. The variability could be explained in large parts (adjusted R2 = 77.2%) by variations in atrial pressures or sizes, together with the degree of excessive pulmonary blood flow and signs of heart failure.A value for atrial natriuretic peptide prohormone above 800 pmol/1 predicted hemodynamic imbalance (defined as elevated pressures in left or right atrium or the pulmonary arteries, and/or Qp/Qs > 1.5) with a specificity of 94%, a sensitivity of 73%, a positive likelihood ratio of 12.2, and a negative likelihood ratio of 0.29.In conclusion, variables related to pulmonary blood flow are influential determinants of the levels of atrial natriureic peptide in children with congenital heart disease. Atrial pressures, and symptoms of heart failure are also of major importance.

scholarly journals The diagnostic and prognostic role of amino-terminal pro-brain type natriuretic peptides in pediatric cardiac diseases and pulmonary hypertension

2021 ◽  
Vol 5 (Volume 1) ◽  
pp. 21
Author(s):  
Kayirnisa Tilemanbetova ◽  
Taalaibek Kudaiberdiev ◽  
Jalil Sheishenov ◽  
Damirbek Abibillaev
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Pediatric Patients ◽  
Heart Diseases ◽  
Congenital Heart Diseases ◽  
Amino Terminal

Objective: Several studies showed that N-terminal pro-brain type natriuretic peptide (NT-pro-BNP) as the reliable marker both in diagnostic and prognostic workup of pediatric patients with congenital heart disease complicated by pulmonary hypertension. Furthermore, it has well assisted both in therapeutic and surgical management of children with congenital heart diseases. In this review, we aimed to analyze recent studies concerning the role of the NT-pro-BNP in pediatric cardiac patients with pulmonary hypertension. Methods: PubMed, Cochrane, Science Direct and Google Scholar databases were used with the searching of the following words: “amino terminal pro brain type natriuretic peptide”, “pediatric pulmonary hypertension”, “congenital heart diseases”, emphasizing on original research articles published within recent 15 years and in English language. We critically analyzed and summarized the retrieved studies. Conclusion: NT-pro-BNP remains as the reliable diagnostic and prognostic marker of pulmonary hypertension and congenital heart diseases in pediatric patients. NT-pro-BNP and BNP remain as the universal marker of cardiovascular pathology in pediatric population. Improvement of their effectiveness in diagnostic workup in patients with CHD and PH undergoing surgery needs further clarification. Key words: pediatric pulmonary hypertension, N-terminal pro brain type natriuretic peptide, congenital heart disease

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