The diagnostic and prognostic role of amino-terminal pro-brain type natriuretic peptides in pediatric cardiac diseases and pulmonary hypertension

Objective: Several studies showed that N-terminal pro-brain type natriuretic peptide (NT-pro-BNP) as the reliable marker both in diagnostic and prognostic workup of pediatric patients with congenital heart disease complicated by pulmonary hypertension. Furthermore, it has well assisted both in therapeutic and surgical management of children with congenital heart diseases. In this review, we aimed to analyze recent studies concerning the role of the NT-pro-BNP in pediatric cardiac patients with pulmonary hypertension. Methods: PubMed, Cochrane, Science Direct and Google Scholar databases were used with the searching of the following words: “amino terminal pro brain type natriuretic peptide”, “pediatric pulmonary hypertension”, “congenital heart diseases”, emphasizing on original research articles published within recent 15 years and in English language. We critically analyzed and summarized the retrieved studies. Conclusion: NT-pro-BNP remains as the reliable diagnostic and prognostic marker of pulmonary hypertension and congenital heart diseases in pediatric patients. NT-pro-BNP and BNP remain as the universal marker of cardiovascular pathology in pediatric population. Improvement of their effectiveness in diagnostic workup in patients with CHD and PH undergoing surgery needs further clarification. Key words: pediatric pulmonary hypertension, N-terminal pro brain type natriuretic peptide, congenital heart disease

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A LITERATURE REVIEW ON ANALYSIS OF PALM PATTERNS TO DETECT CONGENITAL HEART DISEASES

Biomedical Engineering Applications Basis and Communications ◽

10.4015/s101623722050012x ◽

2020 ◽

Vol 32 (02) ◽

pp. 2050012

Author(s):

Y. Mahesha ◽

C. Nagaraju

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Heart Diseases ◽

Congenital Heart Diseases ◽

Normal People ◽

Different Types ◽

Left And Right ◽

Paper Method

This paper presents the survey on different techniques which can be used to detect congenital heart disease using palm patterns. The congenital heart disease is one of the heart diseases which starts from birth. Research works are carried out towards detecting congenital heart disease before symptom appears using palm patterns so that it avoids critical health problems in future. Researchers have collected palm prints from normal people who are not suffering from any kind of heart disease and from patients who are suffering from different types of congenital heart diseases. These palm prints are collected from different hospitals. The palm prints are taken using ink and paper method. These palm patterns are analyzed to determine the role of palm pattern while detection of the disease. Few researchers have considered only triradius of palm and most of the researchers have considered palm patterns such as whorl, loop, arch and hypothenar pattern. In case of triradius, researchers have calculated position of axial triradius and it is categorized into three types. In case of whorl, loop and arch, they have considered how often they appear in palm of normal people and patients. Few researchers have analyzed both left and right hands of normal people and patients.

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Co-existence of Ventricular Septal Defect and Bronchial Asthma in Two Nigerian Children

Clinical Medicine Insights Case Reports ◽

10.4137/ccrep.s4584 ◽

2010 ◽

Vol 3 ◽

pp. CCRep.S4584 ◽

Cited By ~ 1

Author(s):

F. Bode-Thomas ◽

IH. Hyacinth ◽

CS. Yilgwan

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Ventricular Septal Defect ◽

Congenital Heart ◽

Septal Defect ◽

Heart Diseases ◽

Congenital Heart Diseases ◽

Nigerian Children ◽

Airway Diseases

Congenital heart diseases (CHD) often present with recurrent or chronic breathing difficulties, as do chronic airway diseases such as asthma. Both are relatively common, and may sometimes co-exist. However, there is a paucity of literature from developing countries to that effect. We present two children diagnosed with ventricular septal defect, later also found to have clinical features consistent with co-existing asthma. We highlight the diagnostic challenges we encountered as well as the crucial role of a careful family respiratory history in children with congenital heart disease.

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Prevalence and profile of congenital heart disease and pulmonary hypertension in Down syndrome in a pediatric cardiology service

Revista Paulista de Pediatria ◽

10.1590/0103-0582201432218913 ◽

2014 ◽

Vol 32 (2) ◽

pp. 159-163 ◽

Cited By ~ 17

Author(s):

Felipe Alves Mourato ◽

Lúcia Roberta R. Villachan ◽

Sandra da Silva Mattos

Keyword(s):

Congenital Heart Disease ◽

Pulmonary Hypertension ◽

Down Syndrome ◽

Heart Disease ◽

Congenital Heart ◽

Septal Defect ◽

Heart Diseases ◽

Heart Defects ◽

Descriptive Analysis ◽

Atrioventricular Septal Defect

OBJECTIVE:To determine the frequence and profile of congenital heart defects in Down syndrome patients referred to a pediatric cardiologic center, considering the age of referral, gender, type of heart disease diagnosed by transthoracic echocardiography and its association with pulmonary hypertension at the initial diagnosis.METHODS:Cross-sectional study with retrospective data collection of 138 patients with Down syndrome from a total of 17,873 records. Descriptive analysis of the data was performed, using Epi-Info version 7.RESULTS: Among the 138 patients with Down syndrome, females prevailed (56.1%) and 112 (81.2%) were diagnosed with congenital heart disease. The most common lesion was ostium secundum atrial septal defect, present in 51.8%, followed by atrioventricular septal defect, in 46.4%. Ventricular septal defects were present in 27.7%, while tetralogy of Fallot represented 6.3% of the cases. Other cardiac malformations corresponded to 12.5%. Pulmonary hypertension was associated with 37.5% of the heart diseases. Only 35.5% of the patients were referred before six months of age.CONCLUSIONS: The low percentage of referral until six months of age highlights the need for a better tracking of patients with Down syndrome in the context of congenital heart disease, due to the high frequency and progression of pulmonary hypertension.

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Role of TEE in Improving Diagnostic Accuracy of Congenital Heart Disease

Journal of Perioperative Echocardiography ◽

10.5005/jp-journals-10034-1025 ◽

2014 ◽

Vol 2 (2) ◽

pp. 68-70

Author(s):

Sandeep Singh Rana ◽

Balbir Kumar ◽

Sethu Madhavan J

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Diagnostic Accuracy ◽

Multimodal Imaging ◽

Congenital Heart ◽

Heart Diseases ◽

Associated Lesions ◽

Cardiac Lesions ◽

Intraoperative Period

ABSTRACT Complex congenital heart diseases (CHD) often present as multiple cardiac lesions. The presence of one anomaly should stimulate the physician to perform a comprehensive assessment and look for other associated anomalies.1 Multimodal imaging may be necessary to diagnose such associated lesions as single imaging may occasionally miss them. Transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) are complimentary to each other. Routine use of TEE during intraoperative period may help us to refine diagnosis, detect the missing components and guide effective surgical repair. We present one such case where diagnosis and management were optimized by multimodal imaging. How to cite this article Kumar B, Madhavan JS, Puri GD, Rana SS. Role of TEE in Improving Diagnostic Accuracy of Congenital Heart Disease. J Perioper Echocardiogr 2014;2(2):68-70.

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Amino Terminal Fragment of Pro–B-Type Natriuretic Peptide for Complex Congenital Heart Diseases

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2013.10.083 ◽

2014 ◽

Vol 63 (13) ◽

pp. 1342-1343 ◽

Cited By ~ 1

Author(s):

Massimiliano Cantinotti ◽

Aldo Clerico ◽

Michele Emdin

Keyword(s):

Natriuretic Peptide ◽

Congenital Heart ◽

Heart Diseases ◽

Congenital Heart Diseases ◽

Amino Terminal ◽

Terminal Fragment ◽

Amino Terminal Fragment

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THE ROLE OF ATRIAL NATRIURETIC PEPTIDE (ANP) IN CONGENITAL HEART DISEASE

Pediatric Research ◽

10.1203/00006450-198704010-00137 ◽

1987 ◽

Vol 21 (4) ◽

pp. 189A-189A ◽

Cited By ~ 1

Author(s):

Alan L Davis ◽

David S Goldstein ◽

Stephen Shapiro ◽

Murray M Pollack

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Atrial Natriuretic Peptide ◽

Natriuretic Peptide ◽

Congenital Heart ◽

Atrial Natriuretic

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High prevalence of congenital heart disease at high altitudes in Tibet

European Journal of Preventive Cardiology ◽

10.1177/2047487318812502 ◽

2018 ◽

Vol 26 (7) ◽

pp. 756-759 ◽

Cited By ~ 7

Author(s):

Hua Chun ◽

Yan Yue ◽

Yibin Wang ◽

Zhaxi Dawa ◽

Pu Zhen ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Patent Ductus Arteriosus ◽

High Altitude ◽

Congenital Heart ◽

Septal Defect ◽

Heart Diseases ◽

Ductus Arteriosus ◽

Congenital Heart Diseases ◽

Patent Ductus

Background Previous small sample studies suggested that elevated altitudes might be associated with the incidence of cardiovascular diseases. However, it remains uncertain whether high altitudes (over 3000 m above sea level) are related to congenital heart disease. We therefore explored the prevalence of congenital heart disease in a large cohort of students in the world's largest prefecture-level city with the highest altitude. Methods This cross-sectional study included 84,302 student participants (boys 52.12%, girls 47.88%, with an average age of 10.62 ± 3.33 years). Data were extracted from the screening results among different altitude area schools in Nagqu from June 2016 to August 2017. Students were first screened by performing a physical examination consisting of cardiac auscultations and clinical manifestation screenings. An echocardiography was performed to confirm and identify the subtype of congenital heart disease. Results The prevalence of congenital heart disease among students in Nagqu, Tibet, was 5.21‰ (439 cases). The most common congenital heart disease type was patent ductus arteriosus, representing 66.3% of congenital heart diseases diagnosed in this study, followed by atrial septal defect and ventricular septal defect, representing 20.3% and 9.1% of congenital heart diseases, respectively. Students living in higher altitudes were significantly more prone to have congenital heart disease than students in locations with lower altitudes. The prevalence of congenital heart disease in girls was found to be higher than that of boys. Conclusions The correlation between congenital heart disease and increased altitude is noteworthy. This study's results are the first big data epidemiological investigation to confirm that high altitude is a significant environmental risk factor for congenital heart disease, especially patent ductus arteriosus. Furthermore, the results provide additional support to make a diagnostic and treatment plan to prevent congenital heart disease in high altitude areas.

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