scholarly journals Neonatal Urinary Cotinine Correlates With Behavioral Alterations in Newborns Prenatally Exposed to Tobacco Smoke

2007 ◽  
Vol 61 (2) ◽  
pp. 257-261 ◽  
Author(s):  
Giuseppina Mansi ◽  
Francesco Raimondi ◽  
Simona Pichini ◽  
Letizia Capasso ◽  
Micaela Sarno ◽  
...  
2012 ◽  
Vol 13 ◽  
pp. S67-S68
Author(s):  
T.F. Leung ◽  
I.H.S. Chan ◽  
T.C. Liu ◽  
W.C. Chan ◽  
H.Y. Sy ◽  
...  

1984 ◽  
Vol 18 ◽  
pp. 229A-229A
Author(s):  
R Etzel ◽  
R Greenberg ◽  
N Haley ◽  
F Loda

2018 ◽  
Vol 56 (5) ◽  
pp. 3736-3750 ◽  
Author(s):  
Anna Maria Tartaglione ◽  
Chiara Cipriani ◽  
Flavia Chiarotti ◽  
Benedetta Perrone ◽  
Emanuela Balestrieri ◽  
...  

2020 ◽  
Vol 42 (1) ◽  
Author(s):  
Yuya Kawasaki ◽  
Yun-Shan Li ◽  
Yuko Ootsuyama ◽  
Kazuhiko Nagata ◽  
Hiroshi Yamato ◽  
...  

Abstract Introduction Urinary nicotine and cotinine levels are often measured as biomarkers for tobacco smoke exposure. However, these biomarkers are not appropriate to evaluate the effects of quitting smoking for several days, because of their short half-lives. In this study, we focused on the changes in the urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) levels of 55 patients in a smoking cessation program, because of the long half-life. At the same time, urinary 7-methylguanine (m7Gua) and 8-hydroxy-2′-deoxyguanosine (8-OHdG), as DNA damage markers of cigarette smoking, were also measured. Results In the subjects who completed the quit-smoking program (18 subjects out of 55), the urinary nicotine and cotinine levels decreased to 1.7 and 0.2% at 8 weeks after the first visit to the clinic. By contrast, the NNAL levels decreased to 12.3% at 8 weeks after quitting smoking. During the same period, the urinary m7Gua levels significantly decreased, from 27.32 μg/mg creatinine to 14.17 μg/mg creatinine by the elimination of subjects who showed increased levels of NNAL during the smoking cessation program. The 8-OHdG levels were also reduced within the same period, but were not significantly different. From the all data analysis, the urinary levels of cotinine and NNAL positively correlated with the level of m7Gua. Conclusions NNAL may be an appropriate exposure marker for evaluating the smoking status of patients in a smoking cessation program. The urinary cotinine and NNAL levels positively correlated with the m7Gua levels.


1999 ◽  
Vol 18 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Gerhard Scherer ◽  
Irmtrud Meger-Kossien ◽  
Kirsten Riedel ◽  
Thomas Renner ◽  
Michael Meger

1 In order to elucidate the role of exposure to environ-mental tobacco smoke (ETS) in various acute and chronic illnesses in children, it is important to assess the degree of exposure by suitable methods. For this purpose, we determined the exposure to ETS in 39 children (4-15 years) and 43 adults (16+ years) by questionnaires, personal diffusion samplers for nicotine, and cotinine measurements in saliva and urine. In addition, the influence of the smoking status and the location of the home (urban or suburban) on the benzene exposure of the children was investigated. 2 On average, the 24 children living in homes with at least one smoker were exposed to ETS for 3.1 h/d. This is significantly longer (P<0.001) than the daily exposure time of the 15 children from nonsmoking homes (0.3 h/d). The nicotine concentrations on the personal samplers worn over 7 days were 0.615 and 0.046 tghn3 for children from smoking and nonsmoking homes, respectively (P <0.001). Average salivary cotinine levels were 1.95 ng/ml in children from smoking homes and 0.11 ng/ml in children from nonsmoking homes (P<0.01). The corresponding urinary cotinine levels were 29.4 and 4.5 ng/mg creatinine (P<0.001). There was no difference in the extent of ETS exposure between children and adults from smoking households. Adults from nonsmoking homes tended to have higher ETS exposure than children from nonsmoking homes. 3 Exposure to benzene, which was determined by means of personal samplers, measurements of benzene in exhaled air and of the urinary benzene metabolite trans, trans-muconic acid, was not significantly related to the smoking status of the home but primarily dependent on the location of the home.


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