The present work discusses coupled heat and mass transfer during freeze-drying of a rigid product, as well as accelerated freeze-drying where sublimation and desorption occur concurrently. A desorption mushy zone model was developed to describe the desorption drying. An exact solution was obtained for coupled heat and mass transfer with one discrete sublimation moving interface and one desorption mushy zone where mass transfer is controlled by both Fick and Darcy laws. The effects of several parameters on the sublimation and desorption are analyzed and discussed.
Heat and mass transfer scale-up issues during freeze-drying, I: Atypical radiation and the edge vial effect
