scholarly journals Evaluation of manometric temperature measurement (MTM), a process analytical technology tool in freeze drying, part III: Heat and mass transfer measurement

2006 ◽  
Vol 7 (4) ◽  
pp. E105-E111 ◽  
Author(s):  
Xiaolin Charlie Tang ◽  
Steven L. Nail ◽  
Michael J. Pikal
Keyword(s):  
Mass Transfer ◽  
Temperature Measurement ◽  
Heat And Mass Transfer ◽  
Freeze Drying ◽  
Process Analytical Technology ◽  
Transfer Measurement ◽  
Manometric Temperature Measurement ◽  
Technology Tool ◽  
Analytical Technology

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

2018 ◽  
Vol 90 (7) ◽  
pp. 4354-4362 ◽  
Author(s):  
Davinia Brouckaert ◽  
Laurens De Meyer ◽  
Brecht Vanbillemont ◽  
Pieter-Jan Van Bockstal ◽  
Joris Lammens ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Chemical Imaging ◽  
Technology Tool ◽  
Analytical Technology

Temperature Measurement by Sublimation Rate as a Process Analytical Technology Tool in Lyophilization

2019 ◽  
Vol 108 (7) ◽  
pp. 2305-2314 ◽  
Author(s):  
Hidenori Kawasaki ◽  
Toshinori Shimanouchi ◽  
Hiroyuki Sawada ◽  
Hiroshi Hosomi ◽  
Yuta Hamabe ◽  
...  
Keyword(s):  
Temperature Measurement ◽  
Process Analytical Technology ◽  
Sublimation Rate ◽  
Technology Tool ◽  
Analytical Technology

Analysis of Heat and Mass Transfer in Freeze Drying

2003 ◽  
Vol 21 (2) ◽  
pp. 249-263 ◽  
Author(s):  
Farial Jafar ◽  
Mohammed Farid
Keyword(s):  
Mass Transfer ◽  
Heat And Mass Transfer ◽  
Freeze Drying

Coupled Heat and Mass Transfer With One Discrete Sublimation Moving Interface and One Desorption Mushy Zone

1994 ◽  
Vol 116 (1) ◽  
pp. 215-220 ◽  
Author(s):  
Shi-Wen Peng ◽  
Guo-Qian Chen
Keyword(s):  
Mass Transfer ◽  
Exact Solution ◽  
Mushy Zone ◽  
Heat And Mass Transfer ◽  
Freeze Drying ◽  
Zone Model ◽  
Moving Interface

The present work discusses coupled heat and mass transfer during freeze-drying of a rigid product, as well as accelerated freeze-drying where sublimation and desorption occur concurrently. A desorption mushy zone model was developed to describe the desorption drying. An exact solution was obtained for coupled heat and mass transfer with one discrete sublimation moving interface and one desorption mushy zone where mass transfer is controlled by both Fick and Darcy laws. The effects of several parameters on the sublimation and desorption are analyzed and discussed.

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