Simultaneous Determination of Acetaminophen and Synthetic Color(s) by Derivative Spectroscopy in Syrup Formulations and Validation by HPLC: Exposure Risk of Colors to Children

Abstract A derivative spectrophotometric procedure was established for simultaneous determination of propranolol HCI (PP) with hydrochlorothiazide (HTZ) and metoprolol tartrate (MTP) with HTZ in tablet preparations. The method uses first- and second-derivative spectra of tablet extract in 0.01 N NaOH solution. Ratios of analyte concentrations in the mixture were determined by the compensation technique. The zero-crossing point (ZCP) was also used to estimate the amounts of PP and HTZ in the formulations, and results were compared with those from the compensation technique. The results were found to be precise and free from interferences.

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Simultaneous determination of amiloride HCl, hydrochlorothiazide and atenolol in combined formulations by derivative spectroscopy

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/s0731-7085(97)00241-0 ◽

1998 ◽

Vol 17 (4-5) ◽

pp. 877-884 ◽

Cited By ~ 47

Author(s):

C.V.N Prasad ◽

C Parihar ◽

K Sunil ◽

P Parimoo

Keyword(s):

Simultaneous Determination ◽

Derivative Spectroscopy

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Simultaneous Determination of Otilonium Bromide and Diazepam by First-Derivative Spectroscopy

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600811209 ◽

1992 ◽

Vol 81 (12) ◽

pp. 1175-1177 ◽

Cited By ~ 5

Author(s):

Carlo Mannucci ◽

Jacopo Bertini ◽

Aldo Cocchini ◽

Andrea Perico ◽

Franco Salvagnini ◽

...

Keyword(s):

Simultaneous Determination ◽

First Derivative ◽

Derivative Spectroscopy

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Simultaneous Determination of Brimonidine Tartrate and Timolol Maleate by First Derivative and Ratio Derivative Spectroscopy

Journal of Analytical & Pharmaceutical Research ◽

10.15406/japlr.2017.04.00120 ◽

2017 ◽

Vol 4 (6) ◽

Author(s):

Mukthinuthalapati Mathrusri Annapurna

Keyword(s):

Simultaneous Determination ◽

Timolol Maleate ◽

First Derivative ◽

Derivative Spectroscopy ◽

Brimonidine Tartrate

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Simultaneous Determination of Atenolol and Amlodipine Using Second Derivative Spectroscopy

Polytechnic Journal ◽

10.25156/ptj.v9n2y2019.pp25-29 ◽

2019 ◽

Vol 9 (2) ◽

pp. 25-29

Author(s):

Muharram Y. Mohammad ◽

Mohammad S. Abdullah ◽

Sangar S. Sabir

Keyword(s):

Simultaneous Determination ◽

Standard Method ◽

Derivative Spectrophotometry ◽

Second Derivative ◽

Zero Crossing ◽

Derivative Spectroscopy ◽

Second Derivative Spectroscopy ◽

Crossing Point ◽

Good Agreement

The present study describes employing second derivative spectrophotometry for simultaneous determination of atenolol and amlodipine in pure form and in commercial formulations. The method is simple, accurate, precise and economic. Zero crossing point technique was used for analysis of the drugs in the combined formulation. The method was found to be linear in the concentration range 5.0-50.0µg/ml of atenolol at 251nm and 5.0-45.0µg/ml of amlodipine at 264nm. The proposed method was successfully applied to determine atenolol and amlodipine in combined dosage as well as in a separate dosage. The obtained results were in good agreement with standard method.

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