Simultaneous Determination of Metoprolol-Hydrochlorothiazide and Propranolol-Hydrochlorothiazide in Combined Formulations by Derivative Spectroscopy
1997 ◽
Vol 80
(2)
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pp. 325-330
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Keyword(s):
Abstract A derivative spectrophotometric procedure was established for simultaneous determination of propranolol HCI (PP) with hydrochlorothiazide (HTZ) and metoprolol tartrate (MTP) with HTZ in tablet preparations. The method uses first- and second-derivative spectra of tablet extract in 0.01 N NaOH solution. Ratios of analyte concentrations in the mixture were determined by the compensation technique. The zero-crossing point (ZCP) was also used to estimate the amounts of PP and HTZ in the formulations, and results were compared with those from the compensation technique. The results were found to be precise and free from interferences.
2000 ◽
Vol 65
(5-6)
◽
pp. 339-344
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2001 ◽
Vol 68
(1)
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pp. 1-11
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2004 ◽
Vol 87
(6)
◽
pp. 1323-1328
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2014 ◽
Vol 7
(1)
◽
pp. 2350-2355
1992 ◽
Vol 16
(4)
◽
pp. 214-216
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2002 ◽
Vol 85
(4)
◽
pp. 883-888
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2013 ◽
Vol 2013
◽
pp. 1-8
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