BLOOD-BORNE ADRENOCORTICOTROPIN BINDS SPECIFICALLY TO THE MEDIAN EMINENCE-ARCUATE REGION OF THE RAT HYPOTHALAMUS

ABSTRACT Melatonin-binding sites have previously been identified in the suprachiasmatic nucleus (SCN) and median eminence (ME) of the rat. We have further investigated the localization of melatonin-binding sites in the rat hypothalamus and pituitary using the ligand [125I] iodomelatonin and in-vitro autoradiography. The presence of specific melatonin-binding sites in the SCN is confirmed; however the second area of melatonin binding is identified as the pars tuberalis of the pituitary and not the ME as previously described. No other areas which bound melatonin were found in either the pituitary or the hypothalamus.

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Corticotropin Releasing Factor (CRF): Origin and Course of Afferent Pathways to the Median Eminence (ME) of the Rat Hypothalamus

Neuroendocrinology ◽

10.1159/000123996 ◽

1984 ◽

Vol 39 (4) ◽

pp. 296-306 ◽

Cited By ~ 58

Author(s):

Istvan Merchenthaler ◽

Mary A. Hynes ◽

Sandor Vigh ◽

Andrew V. Schally ◽

Peter Petrusz

Keyword(s):

Median Eminence ◽

Corticotropin Releasing Factor ◽

Afferent Pathways ◽

Rat Hypothalamus

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Differential Development of Insulin-Like Growth Factor I Binding in the Suprachiasmatic Nucleus and Median Eminence of the Rat Hypothalamus

Neuroendocrinology ◽

10.1159/000125945 ◽

1991 ◽

Vol 54 (5) ◽

pp. 504-514 ◽

Cited By ~ 6

Author(s):

Kathleen M. Michels ◽

Juan M. Saavedra

Keyword(s):

Growth Factor ◽

Suprachiasmatic Nucleus ◽

Median Eminence ◽

Insulin Like Growth Factor ◽

Rat Hypothalamus ◽

Factor I ◽

Differential Development ◽

Growth Factor I

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Some cellular characteristics of somatostatin neurons and terminals in the periventricular nucleus of the rat hypothalamus and median eminence. Electron microscopic immunohistochemistry

Brain Research ◽

10.1016/0006-8993(83)91153-8 ◽

1983 ◽

Vol 258 (2) ◽

pp. 291-295 ◽

Cited By ~ 20

Author(s):

Y. Ibata ◽

H.L. Obata ◽

S. Kubo ◽

K. Fukui ◽

H. Okamura ◽

...

Keyword(s):

Median Eminence ◽

Electron Microscopic ◽

Rat Hypothalamus ◽

Periventricular Nucleus ◽

Somatostatin Neurons

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Suppression by Corticosterone of Adrenocorticotropin Release from Adenohypophyses Incubated in Krebs–Ringer Bicarbonate Ultrafiltered Plasma

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y72-023 ◽

1972 ◽

Vol 50 (2) ◽

pp. 164-168

Author(s):

Jacob Kraicer ◽

John V. Milligan ◽

Duncan G. Sinclair

Keyword(s):

Plasma Protein ◽

Median Eminence ◽

Acid Extract ◽

Factor Activity ◽

Rat Hypothalamus ◽

Adrenalectomized Rats

Adenohypophyses were incubated in plasma obtained from adrenalectomized rats and pressure dialyzed against Krebs–Ringer bicarbonate. Corticosterone, in concentrations between 20 and 40 μg/100 ml of ultrafiltered plasma protein, suppressed the augmented release of adrenocorticotropin induced by a crude acid extract of rat hypothalamus–stalk–median eminence. Thus corticosterone, in concentrations and conditions comparable to those found in the circulation, will act directly on the adenohypophysis to decrease its response to corticosterone-releasing factor activity.

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