Angiotensin II Receptor and Postreceptor Events in Adrenal Glomerulosa Cells from Streptozotocin-Induced Diabetic Rats with Hypoaldosteronism Division of Endocrinology

Endocrinology ◽  
1991 ◽  
Vol 129 (5) ◽  
pp. 2729-2733 ◽  
Author(s):  
SADAHIDE AZUKIZAWA ◽  
MIHOKO KANEKO ◽  
SHIGERU NAKANO ◽  
TOSHIKAZU KIGOSHI ◽  
KENZO UCHIDA ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Angiotensin Ii Receptor ◽  
Glomerulosa Cells

trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats

Biochimie ◽  
2021 ◽  
Vol 185 ◽  
pp. 117-127
Author(s):  
Zahra Samadi-Noshahr ◽  
Alireza Ebrahimzadeh-Bideskan ◽  
Mosa-Al-Reza Hadjzadeh ◽  
Mohammad Naser Shafei ◽  
Hossein Salmani ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renal Injury ◽  
Diabetic Rats ◽  
Angiotensin Ii Receptor

Internalisation of the type I angiotensin II receptor (ATI) and angiotensin II function in the rat adrenal zona glomerulosa cell.

1994 ◽  
Vol 141 (2) ◽  
pp. R5-R9 ◽  
Author(s):  
G. P. Vinson ◽  
M. M. Ho. ◽  
J.R. Puddefoot ◽  
R. Teja ◽  
S. Barker
Keyword(s):  
Monoclonal Antibody ◽  
Plasma Membrane ◽  
Angiotensin Ii ◽  
Zona Glomerulosa ◽  
Type I ◽  
Specific Monoclonal Antibody ◽  
Angiotensin Ii Receptor ◽  
Cellular Localisation ◽  
Glomerulosa Cells

ABSTRACT Little is known about the cellular localisation of the angiotensin II (AII) type 1 receptor (ATI) in the rat adrenal glomerulosa cell, but some studies have suggested that receptor internalisation and recycling may occur. Using a specific monoclonal antibody (6313/G2) to the first extracellular domain, we show here that most of the receptor is internalised in the unstimulated cell. When viable glomerulosa cells are incubated with 6313/G2, the receptor is transiently concentrated on the cell surface, and aldosterone output is stimulated. This stimulated output is enhanced by neither threshold nor maximal stimulatory concentrations of All amide, although the antibody does not inhibit All binding to the receptor. Conversely, the stimulatory actions of the antibody and those of ACTH are additive. The data suggest that recycling to the plasma membrane is constitutive, or regulated by unknown factors. Retention of the ATI receptor in the membrane is alone enough to allow sufficient G protein interaction to generate maximal stimulatory events.

scholarly journals The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats

2020 ◽  
Vol 142 (3) ◽  
pp. 124-126 ◽  
Author(s):  
Asadur Rahman ◽  
Shamshad J. Sherajee ◽  
Kazi Rafiq ◽  
Hideki Kobara ◽  
Tsutomu Masaki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Angiotensin Ii Receptor ◽  
Neprilysin Inhibitor ◽  
Type 2 Diabetic

H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats

Biochimie ◽  
2016 ◽  
Vol 131 ◽  
pp. 68-76 ◽  
Author(s):  
Anuradha Pandey ◽  
Santosh Kumar Goru ◽  
Almesh Kadakol ◽  
Vajir Malek ◽  
Nisha Sharma ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renal Fibrosis ◽  
Diabetic Rats ◽  
Macrophage Infiltration ◽  
Angiotensin Ii Receptor ◽  
Type 2 Diabetic

Antihyperglycemic action of angiotensin II receptor antagonist, valsartan, in streptozotocin-induced diabetic rats

2003 ◽  
Vol 21 (4) ◽  
pp. 761-769 ◽  
Author(s):  
Paul Chan ◽  
Kar-Lok Wong ◽  
I-Min Liu ◽  
Thing-Fong Tzeng ◽  
Tzu-Lin Yang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Diabetic Rats ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist

A monoclonal antibody to a conserved sequence in the extracellular domain recognizes the angiotensin II AT1 receptor in mammalian target tissues

1993 ◽  
Vol 11 (2) ◽  
pp. 241-245 ◽  
Author(s):  
S Barker ◽  
W Marchant ◽  
M M Ho ◽  
J R Puddefoot ◽  
J P Hinson ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Vascular Endothelium ◽  
Extracellular Domain ◽  
Angiotensin Ii Receptor ◽  
Conserved Sequence ◽  
Initial Characterization ◽  
Rat Liver Cells ◽  
Receptor Cdna ◽  
Glomerulosa Cells

ABSTRACT We have generated hybridomas which secrete monoclonal antibodies to the AT1 subtype of the angiotensin II receptor (AT1 receptor). These were obtained after immunization of Balb C/c mice with synthetic peptides representing sequences from either the extracellular domain (residues 8-17) or the intracellular domain (residues 229-237) of the AT1 receptor. Hybridoma populations were first screened for the production of antibodies which bound to rat liver cells. Further selection, and cloning by limiting dilution, was carried out for antibodies which bound specifically to rat adrenal glomerulosa cells. Confirmation that the antibody designated 6313/G2 interacted with the angiotensin II receptor was obtained using COS-7 cells transfected with AT1A receptor cDNA. In particular, the initial characterization of 6313/G2 showed specific immunofluorescence of vascular endothelium.

Sign in / Sign up

Export Citation Format

Share Document