Central C-type natriuretic peptide but not atrial natriuretic factor lowers blood pressure and adrenocortical secretion in normal conscious sheep.

Endocrinology ◽  
1992 ◽  
Vol 131 (4) ◽  
pp. 1721-1726 ◽  
Author(s):  
C J Charles ◽  
A M Richards ◽  
E A Espiner
Keyword(s):  
Blood Pressure ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
Conscious Sheep ◽  
Atrial Natriuretic

Long-term hemodynamic actions of atrial natriuretic factor (99-126) in conscious sheep

1988 ◽  
Vol 254 (4) ◽  
pp. H811-H815 ◽  
Author(s):  
D. G. Parkes ◽  
J. P. Coghlan ◽  
J. G. McDougall ◽  
B. A. Scoggins
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Stroke Volume ◽  
Blood Volume ◽  
Total Peripheral Resistance ◽  
Atrial Natriuretic Factor ◽  
Peripheral Resistance ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

The hemodynamic and metabolic effects of long-term (5 day) infusion of human atrial natriuretic factor (ANF) were examined in conscious chronically instrumented sheep. Infusion of ANF at 20 micrograms/h, a rate below the threshold for an acute natriuretic effect, decreased blood pressure by 9 +/- 1 mmHg on day 5, associated with a fall in calculated total peripheral resistance. On day 1, ANF reduced cardiac output, stroke volume, and blood volume, effects that were associated with an increase in heart rate and calculated total peripheral resistance and a small decrease in blood pressure. On days 4 and 5 there was a small increase in urine volume and sodium excretion. On day 5 an increase in water intake and body weight was observed. No change was seen in plasma concentrations of renin, arginine vasopressin, glucose, adrenocorticotropic hormone, or protein. This study suggests that the short-term hypotensive effect of ANF results from a reduction in cardiac output associated with a fall in both stroke volume and effective blood volume. However, after 5 days of infusion, ANF lowers blood pressure via a reduction in total peripheral resistance.

Evidence for Atrial Natriuretic Factor Induced Natriuretic Peptide Receptor Subtype Switching in Rat Proximal Tubular Cells during Culture

1998 ◽  
Vol 6 (2) ◽  
pp. 104-111 ◽  
Author(s):  
Sanjay K. Mistry ◽  
Prabal K. Chatterjee ◽  
Roshan P. Weerackody ◽  
Gabrielle M. Hawksworth ◽  
Rachel M. Knott ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Atrial Natriuretic Factor ◽  
Receptor Subtype ◽  
Natriuretic Peptide Receptor ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Peptide Receptor ◽  
Natriuretic Factor ◽  
Proximal Tubular ◽  
Atrial Natriuretic

Influence of blood pressure, heart rate, age, and sex on concentrations of atrial natriuretic factor and cyclic GMP in 124 volunteers.

1989 ◽  
Vol 35 (7) ◽  
pp. 1519-1523 ◽  
Author(s):  
M Wencker ◽  
S Hauptlorenz ◽  
W Moll ◽  
B Puschendorf
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Confidence Interval ◽  
Atrial Natriuretic Factor ◽  
Blood Donation ◽  
Healthy Individuals ◽  
Natriuretic Factor ◽  
Before And After ◽  
Age And Sex ◽  
Atrial Natriuretic

Abstract The significance of increased atrial natriuretic factor (ANF) in relation to blood pressure and age is still controversial. We investigated the influence of blood pressure, age, and some other variables on ANF and its putative second messenger, cGMP. Samples for ANF and cGMP detection were taken from 124 ostensibly healthy individuals who were donating blood. Samples were also collected from 27 volunteers before and after blood donation, to study the influence of bleeding. During blood donation, ANF increased from 78.9 to 87.4 ng/L (P = 0.0035), whereas cGMP remained unchanged. ANF concentrations in 124 healthy individuals, corrected for the influence of bleeding, were 61.5 (SD 26.1) ng/L, with a 95% confidence interval of 10.0 to 112.1 ng/L. Mean cGMP concentrations in plasma were 2.9 (SD 1.45) nmol/L, with a 95% confidence interval of 0.4 to 5.75 nmol/L. Multivariance analysis revealed no significant influence of blood pressure, age, heart rate, or sex on concentrations of either ANF or cGMP in plasma.

Plasma Atrial Natriuretic Factor and Blood Pressure Drops during Hemodialysis

Nephron ◽  
1994 ◽  
Vol 68 (3) ◽  
pp. 301-307
Author(s):  
B. Viron ◽  
J.C. Dussaule ◽  
V. Roger ◽  
J.P. Wolf ◽  
R. Ardaillou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Atrial Natriuretic Factor ◽  
Pressure Drops ◽  
Natriuretic Factor ◽  
Atrial Natriuretic
Sign in / Sign up

Export Citation Format

Share Document