Influence of blood pressure, heart rate, age, and sex on concentrations of atrial natriuretic factor and cyclic GMP in 124 volunteers.

1989 ◽  
Vol 35 (7) ◽  
pp. 1519-1523 ◽  
Author(s):  
M Wencker ◽  
S Hauptlorenz ◽  
W Moll ◽  
B Puschendorf
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Confidence Interval ◽  
Atrial Natriuretic Factor ◽  
Blood Donation ◽  
Healthy Individuals ◽  
Natriuretic Factor ◽  
Before And After ◽  
Age And Sex ◽  
Atrial Natriuretic

Abstract The significance of increased atrial natriuretic factor (ANF) in relation to blood pressure and age is still controversial. We investigated the influence of blood pressure, age, and some other variables on ANF and its putative second messenger, cGMP. Samples for ANF and cGMP detection were taken from 124 ostensibly healthy individuals who were donating blood. Samples were also collected from 27 volunteers before and after blood donation, to study the influence of bleeding. During blood donation, ANF increased from 78.9 to 87.4 ng/L (P = 0.0035), whereas cGMP remained unchanged. ANF concentrations in 124 healthy individuals, corrected for the influence of bleeding, were 61.5 (SD 26.1) ng/L, with a 95% confidence interval of 10.0 to 112.1 ng/L. Mean cGMP concentrations in plasma were 2.9 (SD 1.45) nmol/L, with a 95% confidence interval of 0.4 to 5.75 nmol/L. Multivariance analysis revealed no significant influence of blood pressure, age, heart rate, or sex on concentrations of either ANF or cGMP in plasma.

Effect of atrial natriuretic factor on arterial baroreceptor control of heart rate and blood pressure in conscious rats

1988 ◽  
Vol 6 (4) ◽  
pp. S284-286 ◽  
Author(s):  
Alberto U. Ferrari ◽  
Anna Daffonchio ◽  
Anita Cavallazzi ◽  
Silvia Gerosa ◽  
Giulio Napoletano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Atrial Natriuretic Factor ◽  
Conscious Rats ◽  
Natriuretic Factor ◽  
Atrial Natriuretic ◽  
Arterial Baroreceptor

Effect of bradykinin B2 receptor antagonist and indomethacin on natriuretic and hypotensive responses to atrial natriuretic factor

1994 ◽  
Vol 72 (12) ◽  
pp. 1561-1566 ◽  
Author(s):  
A. T. Veress ◽  
C. K. Chong ◽  
U. Honrath ◽  
H. Sonnenberg
Keyword(s):  
Blood Pressure ◽  
Receptor Antagonist ◽  
Atrial Natriuretic Factor ◽  
Control Group ◽  
Experimental Conditions ◽  
Intraarterial Infusion ◽  
Natriuretic Factor ◽  
Before And After ◽  
Blood Pressure Responses ◽  
Atrial Natriuretic

The effects of inhibition of bradykinin and prostaglandin on the renal and blood pressure responses to atrial natriuretic factor (ANF) were studied in anesthetized rats. Intraarterial infusion of the receptor antagonist D-Arg[Hyp3,Thi5,8,D-Phe7]bradykinin (BKA) at 14 μg/min, a rate sufficient to block the hypotensive response to 250 μg of bradykinin, did not affect the natriuresis due to injection of ANF (UNaV: control, before ANF, 393 ± 101, after ANF, 2322 ± 400 nmol/min; BKA, before ANF, 261 ± 72, after ANF, 2259 ± 390 nmol/min). In contrast, infusion of indomethacin (Indo) reduced the level of sodium excretion both before and especially after ANF administration (UNaV: Indo, before ANF, 75 ± 15, after ANF, 320 nmol/min). The effect of combining BKA with Indo was not different from the effect of Indo alone (UNaV: BKA + Indo, before ANF, 119 ± 26, after ANF, 469 ± 167 nmol/min). The bradykinin antagonist, with or without Indo, was associated with significant hypotension relative to control. Indo, both in the absence and presence of the antagonist, was associated with a progressive decrease in blood pressure compared with control. However, in each case the hypotensive responses to ANF were not different from those in the control group. We conclude that under the present experimental conditions bradykinin does not modify ANF-induced natriuresis. However, inhibition of prostaglandin synthesis by Indo is associated with renal salt retention, reducing natriuresis both before and after ANF administration.Key words: prostaglandin inhibition, D-Arg[Hyp3,Thi5,8,D-Phe7]bradykinin, atrial natriuretic factor.

Long-term hemodynamic actions of atrial natriuretic factor (99-126) in conscious sheep

1988 ◽  
Vol 254 (4) ◽  
pp. H811-H815 ◽  
Author(s):  
D. G. Parkes ◽  
J. P. Coghlan ◽  
J. G. McDougall ◽  
B. A. Scoggins
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Stroke Volume ◽  
Blood Volume ◽  
Total Peripheral Resistance ◽  
Atrial Natriuretic Factor ◽  
Peripheral Resistance ◽  
Natriuretic Factor ◽  
Atrial Natriuretic

The hemodynamic and metabolic effects of long-term (5 day) infusion of human atrial natriuretic factor (ANF) were examined in conscious chronically instrumented sheep. Infusion of ANF at 20 micrograms/h, a rate below the threshold for an acute natriuretic effect, decreased blood pressure by 9 +/- 1 mmHg on day 5, associated with a fall in calculated total peripheral resistance. On day 1, ANF reduced cardiac output, stroke volume, and blood volume, effects that were associated with an increase in heart rate and calculated total peripheral resistance and a small decrease in blood pressure. On days 4 and 5 there was a small increase in urine volume and sodium excretion. On day 5 an increase in water intake and body weight was observed. No change was seen in plasma concentrations of renin, arginine vasopressin, glucose, adrenocorticotropic hormone, or protein. This study suggests that the short-term hypotensive effect of ANF results from a reduction in cardiac output associated with a fall in both stroke volume and effective blood volume. However, after 5 days of infusion, ANF lowers blood pressure via a reduction in total peripheral resistance.

Trout vascular and renal responses to atrial natriuretic factor and heart extracts

1986 ◽  
Vol 251 (3) ◽  
pp. R639-R642 ◽  
Author(s):  
D. W. Duff ◽  
K. R. Olson
Keyword(s):  
Flow Rate ◽  
Atrial Natriuretic Factor ◽  
Pressor Response ◽  
Aortic Pressure ◽  
Urine Flow ◽  
Urine Flow Rate ◽  
Natriuretic Factor ◽  
Long Duration ◽  
Before And After ◽  
Atrial Natriuretic

Dorsal aortic pressure (DAP), urine flow rate, and urinary K+, Na+, and Cl- were monitored in chronically catheterized unanesthetized rainbow trout before and after injection of saline, tissue extracts, or synthetic (rat, Ile-26) atrial natriuretic factor (ANF). Synthetic ANF (1.0 and 10.0 micrograms/kg body wt) and extracts from trout atria and ventricles increased DAP, urine flow rate, and electrolyte excretion. Saline, skeletal muscle extracts, and 0.1 microgram/kg body wt synthetic ANF had no effect on DAP and only minor effects on renal water and ion excretion. The slow-onset long-duration pressor response to ANF and heart extracts contrasted with a rapid short-acting pressor effect of epinephrine. Synthetic ANF (10 micrograms/kg body wt) and ventricular extracts produced marked increases in Na+ and Cl- excretion but only a mild diuresis. Much of the increase in urine flow rate appears to be due to solvent injection. These results show that trout hearts contain an ANF-like material and that mammalian and piscine ANF produce hemodynamic and renal effects upon intra-arterial injection.

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