scholarly journals Regulation of endothelin production and secretion in cultured collecting duct cells by endogenous transforming growth factor-beta.

Endocrinology ◽  
1996 ◽  
Vol 137 (11) ◽  
pp. 5000-5008 ◽  
Author(s):  
J B Schnermann ◽  
X L Zhu ◽  
X Shu ◽  
T Yang ◽  
Y G Huang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Collecting Duct ◽  
Duct Cells ◽  
Collecting Duct Cells ◽  
Growth Factor Beta

scholarly journals Expression of transforming growth factor beta 1 in the submandibular gland of the rat.

1991 ◽  
Vol 39 (12) ◽  
pp. 1707-1711 ◽  
Author(s):  
O Amano ◽  
T Tsuji ◽  
T Nakamura ◽  
S Iseki
Keyword(s):  
Growth Factor ◽  
Submandibular Gland ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Secretory Granules ◽  
Female Rats ◽  
Tgf Beta ◽  
Duct Cells ◽  
Growth Factor Beta ◽  
Rat Submandibular Gland

We employed immunocytochemical and in situ hybridization techniques to study the expression of transforming growth factor beta 1 (TGF-beta 1) in rat submandibular gland. Immunoreactivity for TGF-beta 1 was observed in the cells of granular convoluted tubules (GCTs), striated ducts, and excretory ducts, whereas it was absent in the intercalated ducts and secretory acini in both male and female rats. Immunoelectron microscopy revealed the ultrastructural localization of TGF-beta 1 in the secretory granules of GCT cells. On the other hand, signals for rat TGF-beta 1 mRNA were abundant in the GCT and striated duct cells but were lacking in the excretory duct cells. These results provided evidence for the production of TGF-beta 1 in the GCTs and striated ducts of rat submandibular gland.

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