scholarly journals Dopamine Receptor Expression and Function in Corticotroph Pituitary Tumors

2004 ◽  
Vol 89 (5) ◽  
pp. 2452-2462 ◽  
Author(s):  
Rosario Pivonello ◽  
Diego Ferone ◽  
Wouter W. de Herder ◽  
Johan M. Kros ◽  
Maria Laura Del Basso De Caro ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Pituitary Tumors ◽  
Receptor Expression ◽  
And Function

scholarly journals Dopamine Receptor Expression and Function in Clinically Nonfunctioning Pituitary Tumors: Comparison with the Effectiveness of Cabergoline Treatment

2004 ◽  
Vol 89 (4) ◽  
pp. 1674-1683 ◽  
Author(s):  
Rosario Pivonello ◽  
Carmela Matrone ◽  
Mariagiovanna Filippella ◽  
Luigi M. Cavallo ◽  
Carolina Di Somma ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Receptor ◽  
Pituitary Tumors ◽  
Receptor Expression ◽  
Treatment Schedule ◽  
Α Subunit ◽  
Tumor Mass ◽  
Isoform Expression ◽  
And Function

Abstract The aim of this study was to correlate dopamine receptors and D2 isoform expression with the cabergoline effect on α-subunit secretion in vitro and tumor mass in vivo in clinically nonfunctioning pituitary tumors. Eighteen patients were subjected to neurosurgery, and a tumor sample was used for dopamine receptor and D2 isoform expression evaluation by RT-PCR and the in vitro functional studies. After neurosurgery, nine of 18 patients with persistent tumor were treated with cabergoline and tumor mass was evaluated before and after 1 yr treatment. D2 receptor was expressed in 67% of cases. D2long was found in 50%, D2short in 17%, and both D2 isoforms in 33% of cases. D4 receptor was also expressed in 17% of cases. The in vitro inhibition of α-subunit concentration was found in 56% of cases and was associated with D2 expression (χ2 = 5.6; P < 0.05). After 1 yr of cabergoline treatment, tumor shrinkage was evident in 56% of patients and was associated with D2 expression (χ2 = 5.6; P < 0.05). The expression of D2short rather than D2long isoform is associated with the most favorable response of the tumor to cabergoline treatment. In conclusion, this study demonstrates D2 receptor expression and function in nearly 70% of cases, suggesting a role of this drug in the treatment schedule of clinically nonfunctioning pituitary tumors.

Dopamine Receptor Expression and Function in Clinically Nonfunctioning Pituitary Tumors: Comparison With the Effectiveness of Cabergoline Treatment

2005 ◽  
Vol 60 (1) ◽  
pp. 33-34
Author(s):  
Rosario Pivonello ◽  
Carmela Matrone ◽  
Mariagiovanna Filippella ◽  
Luigi M. Cavallo ◽  
Carolina di Somma ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Pituitary Tumors ◽  
Receptor Expression ◽  
And Function

scholarly journals Dopamine Receptor Expression and Function in Corticotroph Ectopic Tumors

2007 ◽  
Vol 92 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Rosario Pivonello ◽  
Diego Ferone ◽  
Wouter W. de Herder ◽  
Antongiulio Faggiano ◽  
Lisa Bodei ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Receptor Expression ◽  
And Function

D3 dopamine receptor regulation of D5 receptor expression and function in renal proximal tubule cells

2012 ◽  
Vol 35 (6) ◽  
pp. 639-647 ◽  
Author(s):  
Hefei Huang ◽  
Hongmei Ren ◽  
Caiyu Chen ◽  
Xiaoyan Wang ◽  
Jian Yang ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Dopamine Receptor ◽  
Renal Proximal Tubule ◽  
Receptor Expression ◽  
Receptor Regulation ◽  
Proximal Tubule Cells ◽  
Tubule Cells ◽  
Renal Proximal Tubule Cells ◽  
And Function
Sign in / Sign up

Export Citation Format

Share Document