scholarly journals Postmenopausal Osteoporosis and the Detection of So-Called Secondary Causes of Low Bone Density

2005 ◽  
Vol 90 (6) ◽  
pp. 3800-3801 ◽  
Author(s):  
Murray J. Favus
2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Bhavna Daswani ◽  
M. Ikram Khatkhatay

Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by “omics” studies in the last decade or so. The molecules in monocytes that are deregulated in low BMD condition may contribute to processes such as monocyte survival, migration/chemotaxis, adhesion, transendothelial migration, and differentiation into the osteoclast lineage. Each of these processes may be crucial to the overall route of osteoclastogenesis and an increase in any/all of these processes can lead to increased bone resorption and subsequently low bone density. Whether these molecules are indeed the cause or effect is an arena currently unexplored.


2007 ◽  
Vol 37 (1) ◽  
pp. 13
Author(s):  
MITCHEL L. ZOLER

2002 ◽  
Vol 34 (5) ◽  
pp. S134
Author(s):  
A Abdelkerim ◽  
A Nattiv ◽  
F Dorey ◽  
S Hecht ◽  
J C Puffer

2017 ◽  
Vol 167 (12) ◽  
pp. 904 ◽  
Author(s):  
Mary Ann Forciea ◽  
Robert M. McLean ◽  
Amir Qaseem

2011 ◽  
Vol 26 (8) ◽  
pp. 1891-1903 ◽  
Author(s):  
Anna Rufo ◽  
Andrea Del Fattore ◽  
Mattia Capulli ◽  
Francesco Carvello ◽  
Loredana De Pasquale ◽  
...  

Author(s):  
Lisa Swartz Topor ◽  
Patrice Melvin ◽  
Courtney Giancaterino ◽  
Catherine M Gordon

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