scholarly journals Efficacy and Safety of Long-Term Continuous Growth Hormone Treatment in Children with Prader-Willi Syndrome

2009 ◽  
Vol 94 (11) ◽  
pp. 4205-4215 ◽  
Author(s):  
Roderick F. A. de Lind van Wijngaarden ◽  
Elbrich P. C. Siemensma ◽  
Dederieke A. M. Festen ◽  
Barto J. Otten ◽  
Edgar G. A. H. van Mil ◽  
...  
2010 ◽  
Vol 20 ◽  
pp. S35
Author(s):  
R.F.A. de Lind van Wijngaarden ◽  
E.P.C. Siemensma ◽  
D.A.M. Festen ◽  
B.J. Otten ◽  
A.C.S. Hokken-Koelega

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S28-S29
Author(s):  
A. O. Scheimann ◽  
W. J. Klish ◽  
B. Hayslett ◽  
N. Lafuente ◽  
D. Orellana ◽  
...  

Author(s):  
Sin T. Lo ◽  
Dederieke A. M. Festen ◽  
Roderick F. A. Tummers-de Lind van Wijngaarden ◽  
Philippe J. L. Collin ◽  
Anita C. S. Hokken-Koelega

Abstract The aim of this study was to investigate the effect of growth hormone treatment on adaptive functioning in children with Prader-Willi syndrome. Vineland Adaptive Behavior Scale (VABS) was assessed during a randomized controlled trial (RCT) and after 7 years of growth hormone treatment. In the RCT, 75 children (42 infants and 33 prepubertal children) with Prader-Willi syndrome were included. Subsequently, 53 children were treated with long-term growth hormone. Our study demonstrates a marked delay in adaptive functioning in infants and children with Prader-Willi syndrome, which was associated with older age and lower intelligence. Results of the repeated measurements show that the earlier growth hormone treatment was started during infancy, the better the adaptive skills were on the long-term.


2005 ◽  
Vol 90 (9) ◽  
pp. 5247-5253 ◽  
Author(s):  
Stephen F. Kemp ◽  
Joyce Kuntze ◽  
Kenneth M. Attie ◽  
Thomas Maneatis ◽  
S. Butler ◽  
...  

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