Growth hormone treatment of Prader-Willi syndrome has long-term, positive effects on body composition

2015 ◽  
Vol 104 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Charlotte Höybye
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Positive Effects

O0055 IMPACT OF LONG TERM GROWTH HORMONE TREATMENT ON BODY COMPOSITION IN PRADER-WILLI SYNDROME (PWS)

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S28-S29
Author(s):  
A. O. Scheimann ◽  
W. J. Klish ◽  
B. Hayslett ◽  
N. Lafuente ◽  
D. Orellana ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome

scholarly journals Growth hormone treatment for adults with Prader-Willi syndrome: another point of view

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Harry J. Hirsch ◽  
Varda Gross-Tsur
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Motor Development ◽  
Growth Hormone Treatment ◽  
Genetic Diagnosis ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Positive Effects ◽  
Long Term Treatment ◽  
Risk Of Cancer

AbstractGrowth hormone treatment for children with Prader Willi syndrome (PWS) has shown proven benefits not only in increasing final height but also with positive effects on body composition and motor development. In a recent letter to the editor, Hoybye and colleagues recommend growth hormone treatment for adults with PWS based exclusively on the genetic diagnosis and without regard for growth hormone secretory status. We question whether the benefits of growth hormone treatment in PWS adults, mainly improvement in body composition, are significant enough to justify the as yet unkown consequences of long-term treatment in an adult population. Morbidity and mortality in PWS are mainly due to complications of obesity, and growth hormone treatment does not result in a decrease in BMI or waist circumference. Increases in insulin-like factor-1 as a result of growth hormone treatment over the course of several decades in PWS adults raises concern over possible increase risk of cancer. Compliance with daily injections is likely to be poor. We suggest that efforts to provide appropriate dietary and exercise regimens may be more beneficial and cost-effective than advocating for growth hormone treatment for adults with PWS.

scholarly journals Time for a general approval of growth hormone treatment in adults with Prader–Willi syndrome

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Charlotte Höybye ◽  
◽  
Anthony J. Holland ◽  
Daniel J. Driscoll
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Transition Period ◽  
Neurodevelopmental Disorder ◽  
Hormone Treatment ◽  
Psychomotor Development ◽  
Prader Willi Syndrome ◽  
Gh Treatment ◽  
Beneficial Effects ◽  
Positive Effects

AbstractPrader-Willi syndrome (PWS) is a complex, multi-system, neurodevelopmental disorder characterised by neonatal muscular hypotonia, short stature, high risk of obesity, hypogonadism, intellectual disabilities, distinct behavioural/psychiatric problems and abnormal body composition with increased body fat and a deficit of lean body mass. Growth hormone (GH) deficiency and other hormone deficiencies are common due to hypothalamic dysfunction. In children with PWS GH treatment has been widely demonstrated to improve body composition, normalise height and improve psychomotor development. In adults with PWS, GH’s main effects are to maintain normal body structure and metabolism. The positive effects of GH treatment on body composition, physical fitness and beneficial effects on cardiovascular risk markers, behaviour and quality of life in adults with PWS are also well established from several studies. GH treatment is approved for treatment of children with PWS in many countries, but until recently not as a treatment in young adults in the transition period or for adults in general. In this commentary we want to draw attention to the uneven global use of GH treatment, specifically in adults with PWS, and advocate for GH treatment to be approved internationally, not just for children, but also for adults with PWS and based only on the diagnosis of genetically confirmed PWS.

Effects of growth hormone treatment on growth and body composition in Prader-Willi syndrome: a preliminary report

1997 ◽  
Vol 86 (S423) ◽  
pp. 60-62 ◽  
Author(s):  
AC Lindgren ◽  
L. Hagenäs ◽  
J. Müller ◽  
S. Blichfeldt ◽  
M. Rosenborg ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Preliminary Report ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome

scholarly journals Cognitive functioning in children with Prader–Willi syndrome during 8 years of growth hormone treatment

2020 ◽  
Vol 182 (4) ◽  
pp. 405-411
Author(s):  
S H Donze ◽  
L Damen ◽  
E F Mahabier ◽  
A C S Hokken-Koelega
Keyword(s):  
Growth Hormone ◽  
Cognitive Development ◽  
Cognitive Functioning ◽  
Block Design ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Short Term ◽  
Intelligence Scale ◽  
Positive Effects

Objective Children with Prader–Willi syndrome (PWS) have mild to moderate cognitive impairment. Short-term studies showed positive effects of growth hormone (GH) on cognitive development. This study investigated the effects of 8 years of GH on cognitive development in children with PWS. We also investigated whether starting GH during infancy results in higher cognitive functioning after 8 years of GH. Design Longitudinal study in 43 children with PWS during 8 years of GH (median age at GH start 8.1 years). Cognitive functioning after 8 years was compared to another group of 22 children with PWS (median age at GH start 1.4 years). Methods Cognitive functioning was measured by Wechsler Intelligence Scale for Children. Vocabulary, Similarities and Block Design subtests were expressed as standard deviation scores (SDS) and total IQ (TIQ) calculated. Results Estimated mean (95%CI) Block Design SDS changed from −2.2 (−2.6; −1.8) at GH start to −1.8 (−2.2; −1.4) after 8 years of GH (P = 0.18), similarly SDS from −1.5 (−2.1; −0.9) to −1.3 (−1.9; −0.7, P = 0.66) and TIQ from 66 (60; 72) to 69 (63; 75, P = 0.57). Vocabulary SDS remained similar, being −1.9 (−2.3; −1.4) at GH start and −1.9 (−2.4; −1.5) after 8 years (P = 0.85). After 8 years of GH Vocabulary, SDS and TIQ were higher in the children who started GH during infancy, compared to those who started GH later in childhood (P < 0.01, P = 0.04, respectively). Conclusions Cognitive functioning in children with PWS remains similar during long-term GH and develops at the same pace as healthy peers.

Beneficial Effects of Long-Term Growth Hormone Treatment on Adaptive Functioning in Infants With Prader-Willi Syndrome

2015 ◽  
Vol 120 (4) ◽  
pp. 315-327 ◽  
Author(s):  
Sin T. Lo ◽  
Dederieke A. M. Festen ◽  
Roderick F. A. Tummers-de Lind van Wijngaarden ◽  
Philippe J. L. Collin ◽  
Anita C. S. Hokken-Koelega
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Adaptive Functioning ◽  
Controlled Trial ◽  
Hormone Treatment ◽  
Repeated Measurements ◽  
Prader Willi Syndrome ◽  
Beneficial Effects ◽  
Lower Intelligence

Abstract The aim of this study was to investigate the effect of growth hormone treatment on adaptive functioning in children with Prader-Willi syndrome. Vineland Adaptive Behavior Scale (VABS) was assessed during a randomized controlled trial (RCT) and after 7 years of growth hormone treatment. In the RCT, 75 children (42 infants and 33 prepubertal children) with Prader-Willi syndrome were included. Subsequently, 53 children were treated with long-term growth hormone. Our study demonstrates a marked delay in adaptive functioning in infants and children with Prader-Willi syndrome, which was associated with older age and lower intelligence. Results of the repeated measurements show that the earlier growth hormone treatment was started during infancy, the better the adaptive skills were on the long-term.

scholarly journals Efficacy and Safety of Long-Term Continuous Growth Hormone Treatment in Children with Prader-Willi Syndrome

2009 ◽  
Vol 94 (11) ◽  
pp. 4205-4215 ◽  
Author(s):  
Roderick F. A. de Lind van Wijngaarden ◽  
Elbrich P. C. Siemensma ◽  
Dederieke A. M. Festen ◽  
Barto J. Otten ◽  
Edgar G. A. H. van Mil ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Efficacy And Safety ◽  
Continuous Growth

scholarly journals Eight Years of Growth Hormone Treatment in Children With Prader-Willi Syndrome: Maintaining the Positive Effects

2013 ◽  
Vol 98 (10) ◽  
pp. 4013-4022 ◽  
Author(s):  
N. E. Bakker ◽  
R. J. Kuppens ◽  
E. P. C. Siemensma ◽  
R. F. A. Tummers-de Lind van Wijngaarden ◽  
D. A. M. Festen ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Prader Willi Syndrome ◽  
Positive Effects
Sign in / Sign up

Export Citation Format

Share Document