scholarly journals Long-Term Efficacy of a Single Session of RFA for Benign Thyroid Nodules: A Longitudinal 5-Year Observational Study

2019 ◽  
Vol 104 (9) ◽  
pp. 3751-3756 ◽  
Author(s):  
Maurilio Deandrea ◽  
Pierpaolo Trimboli ◽  
Francesca Garino ◽  
Alberto Mormile ◽  
Gabriella Magliona ◽  
...  
Keyword(s):  
Observational Study ◽  
Thyroid Nodules ◽  
Long Term Results ◽  
Categorical Variables ◽  
Single Session ◽  
Term Efficacy ◽  
Nodule Volume ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Abstract Context Radiofrequency ablation (RFA) of benign thyroid nodules has been gaining consensus. However, no solid information on its long-term efficacy is available. Objective To analyze the long-term results of single-session RFA. Design Retrospective longitudinal observational study. Setting Primary care center. Patients or Other Participants Adult outpatients who underwent a single-session RFA and posttreatment follow-up of least 3 years. Intervention Ultrasound-guided RFA was performed after local anesthesia by “moving-shot” technique. RFA was performed with a median power of 55W and a median time of 14 minutes with an internally cooled 18-gauge electrode with an active 10-mm tip. Main Outcome Measures Objective (trend of nodule volume) and subjective (compressive and cosmetic concerns) response to RFA were evaluated. Continuous variables were analyzed by the Wilcoxon and ANOVA test and their correlations by using the Spearman test. Categorical variables were compared by Pearson χ2 test. Results Two hundred and fifteen patients were included. An early significant reduction of nodule volume was found at 1 year, lasting up to 5 years. A 67% nodule shrinkage was observed at the end of the observation period. The best response was recorded in nodules below 10 mL (79% reduction early and 81% at 5 years). Patients’ symptoms were significantly reduced. Conclusions This study, by demonstrating a durable shrinkage of benign thyroid nodules treated by RFA with an improvement of subjective symptoms, establishes the reliability of RFA as alternative to surgery in the management of thyroid nodules, thus representing a remarkable novelty for clinical practice.

scholarly journals Percutaneous, Ultrasound-guided Laser Ablation of Benign Thyroid Nodules: Results of 10-year Follow-up in 171 Patients

2021 ◽  
Author(s):  
Giovanni Gambelunghe ◽  
Elisa Stefanetti ◽  
Nicola Avenia ◽  
Pierpaolo De Feo
Keyword(s):  
Laser Ablation ◽  
Thyroid Nodules ◽  
Single Session ◽  
Ultrasound Guided ◽  
Prolonged Effect ◽  
Nodule Volume ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Abstract Background Percutaneous, ultrasound-guided laser ablation is effective in nodular thyroid disease. The aim of this study was to evaluate the long-term (10-year) efficacy and safety of laser ablation in the treatment of benign thyroid nodules. Methods Between 2009 and 2010, 171 patients received a single session of laser ablation. Evaluation of nodule volume was performed before treatment, at 6 months, and every year. Results Technique efficacy was achieved in 92% of patients at 1 year. Median nodule volume significantly decreased from 16.7 mL (range: 11.0−97.0 mL) at baseline to 5.0 mL (range: 4.1−32.0 mL) at 1 year, a volume reduction ratio (VRR) of 68%. The benefit of the treatment was durable (p < 0.001 vs baseline at all timepoints), with a VRR of 59% after 10 years. No cases of nodule regrowth >50% were observed at 1 year, although such cases did occur after 4 years (n = 3; 1.7% of the overall cohort) and 7 years (n = 8; 4.7%). There were no further cases of regrowth beyond 7 years. When patients were stratified according to baseline nodule volume (<15 mL, 15−25 mL, or >25 mL), durable results were observed across all 3 categories, with the largest, most prolonged effect observed in patients with nodules <15 mL. Treatment was well tolerated, with only minor, transient complications of fever and local pain, and 98% of patients willing to recommend the treatment. Conclusions Percutaneous, ultrasound-guided laser ablation of benign thyroid nodules provides long-term benefits and the treatment is well tolerated.

scholarly journals Long-Term Results of Thermal Ablation of Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 35 (2) ◽  
pp. 339-350 ◽  
Author(s):  
Se Jin Cho ◽  
Jung Hwan Baek ◽  
Sae Rom Chung ◽  
Young Jun Choi ◽  
Jeong Hyun Lee
Keyword(s):  
Systematic Review ◽  
Thermal Ablation ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Long Term Results ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

scholarly journals Long-Term Results of Ultrasound-Guided Radiofrequency Ablation of Benign Thyroid Nodules: State of the Art and Future Perspectives—A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Hervé Monpeyssen ◽  
Ahmad Alamri ◽  
Adrien Ben Hamou
Keyword(s):  
Systematic Review ◽  
Radiofrequency Ablation ◽  
Thyroid Nodules ◽  
Long Term Results ◽  
Future Perspectives ◽  
Time Duration ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

BackgroundNearly 20 years after the first feasibility study, minimally invasive ultrasound (US)-guided therapeutic techniques are now considered as a safe and effective alternative to surgery for symptomatic benign thyroid nodules. Radiofrequency ablation (RFA) is one of the most widely used treatment in specialized thyroid centers but, due to the relatively recent introduction into clinical practice, there are limited long-term follow-up studies. Aim of our work was to review the outcomes of RFA on solid nonfunctioning and on autonomous thyroid nodules (AFTN) on a long-time period for assessing the results in term of efficacy, complications, and costs and to compare them to the current indications of RFA.MethodsA systematic review was performed using EMBASE and Medline library data between 2008 and 2021. Seventeen studies evaluated RFA for the treatment of benign solid (nonfunctioning or autonomous) thyroid nodules, with an at least 18 months of follow-up. Data extraction and quality assessment were performed by two endocrinologist according to PRISMA guidelines. Anthropometric data, safety and efficacy parameters were collected.ResultsThe majority of the studies was retrospective study and reported 933 nodules, mostly solid. Baseline volume ranged between 6.1 ± 9.6 and 36.3 ± 59.8 ml. Local analgesia was used and the time duration of the treatment was between 5 ± 2 and 22.1 ± 10.9 min. The volume reduction rate at 12 months ranged from 67% to 75% for the nodule treated with a single procedure and reached to 93.6 ± 9.7% for nodules treated with repeat ablations. The regrowth rate at 12 months ranged from 0% to 34%.ConclusionAll the studies under examination consistently validated the long-term clinical efficacy and the substantial safety of RFA for the treatment of benign thyroid nodules. Thermal ablation, however, is an operator-dependent technique and should be performed in centers with specific expertise. The selection of the patients should be rigorous because the nodule size and the structural and functional characteristics influence the appropriateness and the outcomes of the treatment. Future perspectives as the treatment of micro-papillary thyroid cancer or cervical recurrence need further investigations.

Post-Operative Long-Term Results of Patients with Benign Thyroid Nodules

2003 ◽  
Vol 3 (2) ◽  
pp. 136
Author(s):  
Ho Kyun Lee ◽  
Jung Han Yoon ◽  
Young Jong Jeagal
Keyword(s):  
Thyroid Nodules ◽  
Long Term Results ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

scholarly journals Long-Term Outcome of Microwave Ablation for Benign Thyroid Nodules: A 48-Month Follow-up Study

2021 ◽  
Author(s):  
Jia-Rui Du ◽  
Wen-Hui Li ◽  
Cheng-Hai Quan ◽  
Deng-Ke Teng ◽  
Hui Wang
Keyword(s):  
Thyroid Function ◽  
Microwave Ablation ◽  
Thyroid Nodules ◽  
Reduction Rate ◽  
Long Term Results ◽  
Long Term Outcome ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Abstract Purpose The short-term effects of microwave ablation (MWA) in the treatment of benign thyroid nodules (BTNs) were satisfactory in previous studies. However, as a slowly progressing disease, the long-term efficacy of MWA for BTNs at present is not clear. Our study aim was to assess the long-term results of MWA for BTNs after a 48-month follow-up. Methods From June 2015 to September 2017, 148 patients had 148 BTNs lesions. All patients were from China-Japan Union Hospital of Jilin University. Careful ultrasound examinations were performed 1 day, 1 month, 3 months, 6 months, 12 months, and every 6 months after MWA. The volume, volume reduction rate (VRR) recurrence rate of the ablated area and thyroid function were recorded. Results The mean volume of the 148 nodules were 15.6±9.4 cm3 (range: 1.3-48.9 cm3) and 0.6±0.6 cm3 (range: 0-3.5 cm3) before and 48 months after MWA, respectively, for a nodule VRR of 96.9±2.5% (range: 90.4-100%). Two patients (1.35%) had recurrence after MWA. Compared with that before MWA, no significant variation in thyroid function was observed after MWA. Five patients experienced complications (3.38%): two patients (1.35%) had bleeding, two patients (1.35%) had ear pain and toothache during MWA, and one patient (0.68%) had hoarseness after MWA. No cases of oesophageal injury, tracheal injury, infection, skin burn, etc., were reported during or after MWA. Conclusions Over long-term follow-up, MWA is an effective method for treating BTNs and is expected to be a potential first-line treatment.

Single session treatment of benign thyroid nodules with radiofrecuency ablation: results at 6 months in 17 patients

2018 ◽  
Author(s):  
Cristina Familiar ◽  
Salome Merino ◽  
Tomas Ganado ◽  
Ines Jimenez ◽  
Concepcion Sanabria
Keyword(s):  
Thyroid Nodules ◽  
Single Session ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Single-session high-intensity focused ultrasound (HIFU) ablation for benign thyroid nodules: a systematic review

2020 ◽  
Vol 17 (8) ◽  
pp. 759-771
Author(s):  
Eleftherios Spartalis ◽  
Sotirios P. Karagiannis ◽  
Nikolaos Plakopitis ◽  
Maria Anna Theodori ◽  
Dimosthenis Chrysikos ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Thyroid Nodules ◽  
High Intensity Focused Ultrasound ◽  
Single Session ◽  
Hifu Ablation ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid
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