Subcutaneous administration of the amino-terminal fragment of human parathyroid hormone-(1-34): kinetics and biochemical response in estrogenized osteoporotic patients

1993 ◽  
Vol 77 (6) ◽  
pp. 1535-1539 ◽  
Author(s):  
R. Lindsay
Keyword(s):  
Parathyroid Hormone ◽  
Subcutaneous Administration ◽  
Biochemical Response ◽  
Human Parathyroid Hormone ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

Acute Administration of Intact Parathyroid Hormone but Not Its Amino-Terminal Fragment Stimulates Volume of Pancreatic Secretion

Nephron ◽  
1991 ◽  
Vol 57 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Mohamed A. El-Shahawy ◽  
George Z. Fadda ◽  
James R. Wisner, Jr ◽  
Ian G. Renner ◽  
Hidecki Omachi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Pancreatic Secretion ◽  
Acute Administration ◽  
Intact Parathyroid Hormone ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

scholarly journals Selective Uptake of the Synthetic Amino Terminal Fragment of Bovine Parathyroid Hormone by Isolated Perfused Bone

1978 ◽  
Vol 62 (2) ◽  
pp. 256-261 ◽  
Author(s):  
Kevin J. Martin ◽  
Jeffrey J. Freitag ◽  
Mary B. Conrades ◽  
Keith A. Hruska ◽  
Saulo Klahr ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Selective Uptake ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment ◽  
Bovine Parathyroid Hormone

Biologically active amino-terminal fragment of bovine parathyroid hormone prepared by dilute acid hydrolysis

Biochemistry ◽  
1972 ◽  
Vol 11 (10) ◽  
pp. 1973-1979 ◽  
Author(s):  
Henry T. Keutmann ◽  
Bess F. Dawson ◽  
Gerald D. Aurbach ◽  
John T. Potts
Keyword(s):  
Parathyroid Hormone ◽  
Acid Hydrolysis ◽  
Biologically Active ◽  
Dilute Acid ◽  
Dilute Acid Hydrolysis ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment ◽  
Bovine Parathyroid Hormone

scholarly journals Evolution of the hedgehog Gene Family

Genetics ◽  
1996 ◽  
Vol 142 (3) ◽  
pp. 965-972 ◽  
Author(s):  
Sudhir Kumar ◽  
Kristi A Balczarek ◽  
Zhi-Chun Lai
Keyword(s):  
Intercellular Communication ◽  
Short Range ◽  
Gene Duplications ◽  
Future Directions ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Carboxyl Terminal ◽  
Multicellular Organisms ◽  
Amino Terminal Fragment

Abstract Effective intercellular communication is an important feature in the development of multicellular organisms. Secreted hedgehog (hh) protein is essential for both long- and short-range cellular signaling required for body pattern formation in animals. In a molecular evolutionary study, we find that the vertebrate homologs of the Drosophila hh gene arose by two gene duplications: the first gave rise to Desert hh, whereas the second produced the Indian and Sonic hh genes. Both duplications occurred before the emergence of vertebrates and probably before the evolution of chordates. The amino-terminal fragment of the hh precursor, crucial in long- and short-range intercellular communication, evolves two to four times slower than the carboxyl-terminal fragment in both Drosophila hh and its vertebrate homologues, suggesting conservation of mechanism of hh action in animals. A majority of amino acid substitutions in the amino- and carboxyl-terminal fragments are conservative, but the carboxyl-terminal domain has undergone extensive insertion-deletion events while maintaining its autocleavage protease activity. Our results point to similarity of evolutionary constraints among sites of Drosophila and vertebrate hh homologs and suggest some future directions for understanding the role of hh genes in the evolution of developmental complexity in animals.

The amino‐terminal fragment of human urokinase directs a recombinant chimeric toxin to target cells: internalization is toxin mediated

1997 ◽  
Vol 11 (13) ◽  
pp. 1169-1176 ◽  
Author(s):  
M. Serena Fabbrini ◽  
Daniela Carpani ◽  
Iraldo Bello‐Rivero ◽  
Marco R. Soria
Keyword(s):  
Target Cells ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment
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