Alteration in insulin-like growth factor-binding proteins (IGFBPs) and IGFBP-3 protease activity in serum and urine from acute and chronic renal failure

1994 ◽  
Vol 79 (5) ◽  
pp. 1376-1382 ◽  
Author(s):  
D. Y. Lee
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Protease Activity ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Serum And Urine ◽  
Igfbp 3

Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure

1996 ◽  
Vol 10 (3) ◽  
pp. 343-347 ◽  
Author(s):  
David R. Powell ◽  
Frances Liu ◽  
Bonita K. Baker ◽  
Phillip D. K. Lee ◽  
Raymond L. Hintz
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Growth Inhibitors ◽  
Factor Binding

Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure

1996 ◽  
Vol 10 (3) ◽  
pp. 343-347 ◽  
Author(s):  
David R. Powell ◽  
Frances Liu ◽  
Bonita K. Baker ◽  
Phillip D. K. Lee ◽  
Raymond L. Hintz
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Growth Inhibitors ◽  
Factor Binding

Insulin-like growth factor binding protein-3 protease activity in the urine of children with chronic renal failure

1993 ◽  
Vol 7 (4) ◽  
pp. 416-423 ◽  
Author(s):  
Dae-Yeol Lee ◽  
Pinchas Cohen ◽  
Alan M. Krensky ◽  
Ron G. Rosenfeld ◽  
Peter D. Yorgin
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Protease Activity ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Impaired Postprandial Regulation of Insulin-Like Growth Factor Binding Protein-1 in Children with Chronic Renal Failure

1997 ◽  
Vol 82 (9) ◽  
pp. 2832-2835 ◽  
Author(s):  
Dieter Haffner ◽  
Werner F. Blum ◽  
Udo Heinrich ◽  
Otto Mehls ◽  
Burkhard Tönshoff
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Profiling of Insulin-like Growth Factor Binding Proteins (IGFBPs) in Obesity and Their Association with Ox-LDL and Hs-CRP in Adolescents

2021 ◽  
Author(s):  
Abdur Rahman ◽  
Maha M. Hammad ◽  
Irina Al Khairi ◽  
Preethi Cherian ◽  
Reem Al-Sabah ◽  
...  
Keyword(s):  
Growth Factor ◽  
Weight Status ◽  
Binding Proteins ◽  
Overweight And Obesity ◽  
Insulin Like Growth Factor ◽  
Central Adiposity ◽  
Metabolic Complications ◽  
Factor Binding ◽  
Hs Crp ◽  
Igfbp 3

Insulin-like growth factor binding proteins (IGFBPs) are critical modulators of the metabolism. In adults, IGFBPs are associated with obesity and insulin resistance but the association of IGFBPs with metabolic homeostasis in children and adolescents is not fully characterized. In this study we investigated the association of plasma IGFBPs (IGFBP-1, 3 and 7) with weight status, central adiposity and cardiovascular disease markers Hs-CRP and Ox-LDL. A total of 420 adolescents (age 11-14 years) were randomly recruited from public middle schools in Kuwait. IGFBPs were measured using bead-based multiplexing while Hs-CRP and Ox-LDL were measured using ELISA. IGFBP-1 levels were significantly lower in obese and overweight participants compared to normal weight children. Only IGFBP-1 was negatively associated with waist circumference to height (WC/Ht) ratio. IGFBP-1 was negatively correlated with Hs-CRP while IGFBP-3 and IGFBP-7 were negatively correlated with Ox-LDL. These data demonstrate a robust negative association of IGFBP-1, but not IGFBP-3 or -7, with overweight and obesity, and the inflammation marker Hs-CRP. Central adiposity (WC/Ht ratio) was a stronger predictor of IGFBP-1 than BMI-for-age z-score. IGFBP-1 could thus be used as a sensitive predictive diagnostic tool for obesity and its subsequent effects in screening and monitoring of obesity-related metabolic complications in adolescents.

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