Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure

1996 ◽  
Vol 10 (3) ◽  
pp. 343-347 ◽  
Author(s):  
David R. Powell ◽  
Frances Liu ◽  
Bonita K. Baker ◽  
Phillip D. K. Lee ◽  
Raymond L. Hintz
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Growth Inhibitors ◽  
Factor Binding

Insulin-like growth factor binding proteins as growth inhibitors in children with chronic renal failure

1996 ◽  
Vol 10 (3) ◽  
pp. 343-347 ◽  
Author(s):  
David R. Powell ◽  
Frances Liu ◽  
Bonita K. Baker ◽  
Phillip D. K. Lee ◽  
Raymond L. Hintz
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Growth Inhibitors ◽  
Factor Binding

scholarly journals Impaired Postprandial Regulation of Insulin-Like Growth Factor Binding Protein-1 in Children with Chronic Renal Failure

1997 ◽  
Vol 82 (9) ◽  
pp. 2832-2835 ◽  
Author(s):  
Dieter Haffner ◽  
Werner F. Blum ◽  
Udo Heinrich ◽  
Otto Mehls ◽  
Burkhard Tönshoff
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Bioactivity of a 29-Kilodalton Insulin-Like Growth Factor Binding Protein-3 Fragment Present in Excess in Chronic Renal Failure Serum

1997 ◽  
Vol 42 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Susan K Durham ◽  
Subburaman Mohan ◽  
Frances Liu ◽  
Bonita K Baker ◽  
Phillip D K Lee ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

1993 ◽  
Vol 33 (2) ◽  
pp. 136-143 ◽  
Author(s):  
David R Powell ◽  
Francis Liu ◽  
Bonita Baker ◽  
Philip D K Lee ◽  
Craig W Belsha ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Insulin-like growth factor-1 and its binding proteins during a low-protein diet in chronic renal failure.

1995 ◽  
Vol 6 (5) ◽  
pp. 1427-1433
Author(s):  
D Fouque ◽  
Y Le Bouc ◽  
M Laville ◽  
F Combarnous ◽  
M O Joly ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Growth Factor ◽  
Protein Intake ◽  
Binding Proteins ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Insulin Like Growth Factor ◽  
Low Protein ◽  
Keto Acids

The effects of a low-protein diet on the serum insulin-like growth factor (IGF)-1 and IGF binding proteins (IGFBP) were investigated during a 3-month controlled study in 12 adult chronic renal failure patients. Six patients were randomly supplemented with keto acids (Cetolog, Clintec, Velizy, France). Protein intake was prescribed so that both groups were isonitrogenous. Dietary survey included a monthly 3-day food record and a 24-h urinary urea measurement. After a 4- to 6-wk equilibrium period (1.11 g of protein, 32 kcal/kg body wt per day), patients reduced their protein intake to 0.71 g protein/kg body wt per day. Energy intake was kept constant (31 kcal/kg body wt per day) during the 3-month period. Serum IGF-1 levels were in normal range and, for 11 of the 12 patients, were correlated with the GFR (P = 0.01). These serum IGF-1 values did not decrease after reducing the protein intake. By Western ligand blotting, serum IGFBP1, IGFBP2, and IGFBP4 levels were significantly higher than normal adults, whereas the IGFBP3 level was not increased. IGFBP were not modified when protein intake was reduced. The IGFBP1 level was elevated despite a normal insulin level. IGFBP4 changes were inversely correlated with IGF-1 variations. There was no difference between groups receiving or not receiving the keto acids. Thus, in adult chronic renal failure, reducing protein intake by 40% did not modify the growth hormone/IGF-1/IGFBP axis.

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