Nitrendipine treatment in women with polycystic ovarian syndrome: evidence for a lack of effects of calcium channel blockers on insulin, androgens, and sex hormone-binding globulin

1995 ◽  
Vol 80 (11) ◽  
pp. 3346-3350 ◽  
Author(s):  
R. Pasquali
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Polycystic Ovarian Syndrome ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Channel Blockers ◽  
Hormone Binding ◽  
Ovarian Syndrome

The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome*

1993 ◽  
Vol 60 (4) ◽  
pp. 626-633 ◽  
Author(s):  
Richard P. Buyalos ◽  
Mitchell E. Geffner ◽  
Richard M. Watanabe ◽  
Richard N. Bergman ◽  
Jeffrey A. Gornbein ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Sex Steroids ◽  
Polycystic Ovarian Syndrome ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovarian Syndrome

scholarly journals DETERMINATION OF SERUM SEX HORMONE BINDING GLOBULIN IN POLYCYSTIC OVARIAN SYNDROME & HEALTHY WOMEN

2019 ◽  
Vol 9 (4) ◽  
pp. 381-389
Author(s):  
Razaw O. Ibrahim ◽  
◽  
Shirwan H. Omer ◽  
Chro N. Fattah ◽  
◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Healthy Women ◽  
Ovarian Syndrome

scholarly journals Comparison of Clinical and Biochemical Markers of Hirsutism in Polycystic Ovary Syndrome – A Study from a Teaching Hospital in Sri Ramachandra Institute, Chennai, India

2021 ◽  
Vol 10 (16) ◽  
pp. 1140-1144
Author(s):  
Nandhini Logaprabhu ◽  
Sarmishta Murugesan
Keyword(s):  
Biochemical Markers ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Free Androgen Index ◽  
Bioavailable Testosterone ◽  
Ovarian Syndrome

BACKGROUND We wanted to analyse the clinical profile of polycystic ovarian syndrome (PCOS) women with history, examination and ultrasonogram and correlate hirsutism with biochemical markers as free testosterone, dehydro-epiandrosterone sulphate (DHEAS), sex hormone binding globulin (SHBG), free testosterone, DHEAS, and SHBG. METHODS This study is a prospective observational study conducted from 2011 to 2013 in the Department of Obstetrics and Gynaecology, Shree Balaji Medical College and Hospital, Chrompet in patients attending Gynaecology OPD. 100 women visiting the OPD were taken as control and 100 women were taken for PCOS study. RESULTS Hyperandrogenism was studied and all the biochemical markers were significantly higher in polycystic ovarian syndrome patients than in controls (P < 0.0001). The highest AUC-ROC was found for bioavailable testosterone (0.852) followed by free androgen index (0.847) and free testosterone (0.837). Lower AUC-ROC was found for androstenedione, total testosterone and SHBG (0.706, 0.799 and 0.76, respectively). When free androgen index of 4.97 was taken as a cut off value, sensitivity was 71.4 % and specificity was 85.2 %. A cut off of 0.78 nmol / L for bioavailable testosterone had even higher sensitivity of 75.9 %, but slightly lower specificity of 83.3 %. Bioavailable testosterone and free androgen index correlated significantly (all P < 0.05) with DHEAS, LH / FSH ratio, androstenedione and total testosterone. In addition, bioavailable testosterone, free androgen index, and free testosterone correlated significantly with follicle count, ovarian volume, and hirsutism scores. CONCLUSIONS White women have about 20 % of excess of dehydro-epiandrosterone sulphate (DHEAS) and black women have 30 % excess of dehydro-epiandrosterone sulphate (DHEAS) in those having poly cystic ovaries patients. There is an age-associated decline in DHEAS levels which is similar in both control and poly cystic ovaries women, regardless of the race which was seen in this study. KEY WORDS Free Testosterone, Dehydro–Epiandrosterone Sulphate (DHEAS), Sex Hormone Binding Globulin (SHBG)

scholarly journals Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

2020 ◽  
Vol 21 (21) ◽  
pp. 8191
Author(s):  
Xianqin Qu ◽  
Richard Donnelly
Keyword(s):  
Therapeutic Target ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Alcoholic Fatty Liver ◽  
Clinical Observations ◽  
Early Biomarker ◽  
Ovarian Pathology ◽  
Ovarian Syndrome

Human sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver that binds sex steroids with high affinity and specificity. Clinical observations and reports in the literature have suggested a negative correlation between circulating SHBG levels and markers of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. Decreased SHBG levels increase the bioavailability of androgens, which in turn leads to progression of ovarian pathology, anovulation and the phenotypic characteristics of polycystic ovarian syndrome (PCOS). This review will use a case report to illustrate the inter-relationships between SHBG, NAFLD and PCOS. In particular, we will review the evidence that low hepatic SHBG production may be a key step in the pathogenesis of PCOS. Furthermore, there is emerging evidence that serum SHBG levels may be useful as a diagnostic biomarker and therapeutic target for managing women with PCOS.

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