scholarly journals Comparison of Clinical and Biochemical Markers of Hirsutism in Polycystic Ovary Syndrome – A Study from a Teaching Hospital in Sri Ramachandra Institute, Chennai, India

2021 ◽  
Vol 10 (16) ◽  
pp. 1140-1144
Author(s):  
Nandhini Logaprabhu ◽  
Sarmishta Murugesan
Keyword(s):  
Biochemical Markers ◽  
Polycystic Ovarian Syndrome ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Free Androgen Index ◽  
Bioavailable Testosterone ◽  
Ovarian Syndrome

BACKGROUND We wanted to analyse the clinical profile of polycystic ovarian syndrome (PCOS) women with history, examination and ultrasonogram and correlate hirsutism with biochemical markers as free testosterone, dehydro-epiandrosterone sulphate (DHEAS), sex hormone binding globulin (SHBG), free testosterone, DHEAS, and SHBG. METHODS This study is a prospective observational study conducted from 2011 to 2013 in the Department of Obstetrics and Gynaecology, Shree Balaji Medical College and Hospital, Chrompet in patients attending Gynaecology OPD. 100 women visiting the OPD were taken as control and 100 women were taken for PCOS study. RESULTS Hyperandrogenism was studied and all the biochemical markers were significantly higher in polycystic ovarian syndrome patients than in controls (P < 0.0001). The highest AUC-ROC was found for bioavailable testosterone (0.852) followed by free androgen index (0.847) and free testosterone (0.837). Lower AUC-ROC was found for androstenedione, total testosterone and SHBG (0.706, 0.799 and 0.76, respectively). When free androgen index of 4.97 was taken as a cut off value, sensitivity was 71.4 % and specificity was 85.2 %. A cut off of 0.78 nmol / L for bioavailable testosterone had even higher sensitivity of 75.9 %, but slightly lower specificity of 83.3 %. Bioavailable testosterone and free androgen index correlated significantly (all P < 0.05) with DHEAS, LH / FSH ratio, androstenedione and total testosterone. In addition, bioavailable testosterone, free androgen index, and free testosterone correlated significantly with follicle count, ovarian volume, and hirsutism scores. CONCLUSIONS White women have about 20 % of excess of dehydro-epiandrosterone sulphate (DHEAS) and black women have 30 % excess of dehydro-epiandrosterone sulphate (DHEAS) in those having poly cystic ovaries patients. There is an age-associated decline in DHEAS levels which is similar in both control and poly cystic ovaries women, regardless of the race which was seen in this study. KEY WORDS Free Testosterone, Dehydro–Epiandrosterone Sulphate (DHEAS), Sex Hormone Binding Globulin (SHBG)

Total testosterone, free-androgen index, calculated free testosterone, and free testosterone by analog RIA compared in hirsute women and in otherwise-normal women with altered binding of sex-hormone-binding globulin.

1987 ◽  
Vol 33 (8) ◽  
pp. 1372-1375 ◽  
Author(s):  
T J Wilke ◽  
D J Utley
Keyword(s):  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Diagnostic Efficiency ◽  
Hormone Binding ◽  
Clinical Value ◽  
Free Androgen Index ◽  
Normal Limits ◽  
Normal Women

Abstract We compared the clinical value of information on free testosterone as measured with the Coat-A-Count (Diagnostic Products Corp.) radioimmunoassay kit involving a ligand analog with that of total testosterone, the free-androgen index, and free testosterone calculated from concentrations of testosterone, sex-hormone-binding globulin, and albumin, in hirsute women, pregnant women, oral-contraceptive users, women with thyroid disease, and epileptic women taking phenytoin. Total testosterone, the free-androgen index, calculated free testosterone, and free testosterone by RIA were increased in 41-68% of hirsute women. Values for free testosterone increased in the first and third trimesters of pregnancy but remained within normal limits in all non-hirsute groups. Total testosterone was increased in patients having increased sex-hormone-binding globulin, whereas the free-androgen index and, to a lesser extent, calculated free testosterone were significantly decreased. Free testosterone measured by analog RIA not only has greater diagnostic efficiency than total testosterone, it also is technically simpler to determine than the free-androgen index and calculated free testosterone.

Determination of testosterone in serum not bound by sex-hormone-binding globulin: diagnostic value in hirsute women.

1988 ◽  
Vol 34 (9) ◽  
pp. 1826-1829 ◽  
Author(s):  
S Loric ◽  
J Guéchot ◽  
F Duron ◽  
P Aubert ◽  
J Giboudeau
Keyword(s):  
Ammonium Sulfate ◽  
Free Testosterone ◽  
Diagnostic Value ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Ammonium Sulfate Precipitation ◽  
Clinical Value ◽  
Free Androgen Index

Abstract We compared the diagnostic value of information given by total testosterone (I), free testosterone (II), the free androgen index (III), and testosterone not bound by sex-hormone-binding globulin (SHBG) (IV) as measured by a new differential ammonium sulfate precipitation technique, each step of which is conducted at 37 degrees C. SHBG and albuminemia were also measured. To examine the clinical value of IV, we analyzed single blood samples from 15 hirsute women and 15 age-matched healthy control volunteers. Values for I, II, III, and IV testosterone were all significantly higher in the hirsute group (P less than 0.01), whereas SHBG was decreased (P less than 0.01) and albumin concentrations were similar for the two groups. Overlap between values for normal and for hirsute women was 33.3% for I, 13.3% for II, and 0% for III and IV. The presented data suggest that IV measured by ammonium sulfate precipitation is the preferred discriminator for detecting hyperandrogenism, because this assay is technically simpler and less expensive than the II assay for routine investigation. It closely reflects the pool of bioavailable testosterone; thus, its main use might be as a screening test for androgen excess in women.

scholarly journals Association of total testosterone, free testosterone, bioavailable testosterone, sex hormone–binding globulin, and hypertension

Medicine ◽  
2019 ◽  
Vol 98 (20) ◽  
pp. e15628 ◽  
Author(s):  
Qingtao Yang ◽  
Zhenjie Li ◽  
Wencai Li ◽  
Liang Lu ◽  
Haoqiang Wu ◽  
...  
Keyword(s):  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Bioavailable Testosterone

Sex-specific young adult reference ranges for sex hormone concentrations measured on the Siemens ADVIA Centaur/Geschlechtsspezifische Referenzbereiche für Sexualhormonkonzentrationen junger Erwachsener gemessen auf dem Siemens ADVIA Centaur

2012 ◽  
Vol 36 (1) ◽  
Author(s):  
Anke Hannemann ◽  
Nele Friedrich ◽  
Christin Spielhagen ◽  
Matthias Nauck ◽  
Robin Haring
Keyword(s):  
Regression Models ◽  
Free Testosterone ◽  
Dehydroepiandrosterone Sulfate ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Reference Ranges ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Free Androgen Index

AbstractThe present study aims to determine reference ranges for sex hormone concentrations measured on the Siemens ADVIA CentaurThe study sample consisted of 1638 individuals (814 men and 824 women) aged 18–60 years with measured serum concentrations of total testosterone (TT), sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS). Values for free testosterone (free T) and free androgen index (FAI) were calculated. Sex- and age-specific (18 to <25, 25 to <35, 35 to <45, and ≥45 years) reference ranges for these sex hormones were determined using quantile regression models for each sex hormone separately.Sex hormone reference ranges were determined across each single year of age separately for men (TT: 5.60–29.58 nmol/L, SHBG: 17.65–73.64 nmol/L, DHEAS: 0.96–4.43 mg/L, free T: 0.10–0.51 nmol/L, and FAI: 15.04–70.37 nmol/L) and women (TT: 0.77–2.85 nmol/L, SHBG: 27.06–262.76 nmol/L, DHEAS: 0.50–3.15 mg/L, free T: 0.005–0.05 nmol/L, and FAI: 0.51–8.30 nmol/L), respectively.

scholarly journals Testosterone, sex hormone-binding globulin, calculated free testosterone, and oestradiol in male vegans and omnivores

1990 ◽  
Vol 64 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Timothy J. A. Key ◽  
Liane Roe ◽  
Margaret Thorogood ◽  
John W. Moore ◽  
Graham M. G. Clark ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Vegan Diet ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Diet Records

Total testosterone (T), total oestradiol (E2) and sex hormone-binding globulin (SHBG) concentrations were measured in plasma samples from fifty-one male vegans and fifty-seven omnivores of similar age. Free T concentration was estimated by calculation, in comparison with the omnivores, the vegans had 7% higher total T (P = 0.250), 23% higher SHBG (P = 0.001), 3% lower free T (P = 0.580), and 11% higher E2 (P = 0.194). In a subset of eighteen vegans and twenty-two omnivores for whom 4 d diet records were available, there were statistically significant correlations between T and polyunsaturated fatty acids (r 0.37), SHBG and fat (r 0.43 for total fat, 0.46 for saturated fatty acids and 0.33 for polyunsaturated fatty acids), and SHBG and alcohol (r–0.39). It is concluded that a vegan diet causes a substantial increase in SHBG but has little effect on total or free T or on E2.

Peripheral hormone levels in healthy subjects during controlled fasting

1986 ◽  
Vol 113 (3) ◽  
pp. 457-462 ◽  
Author(s):  
Ragnar Tegelman ◽  
Pia Lindeskog ◽  
Kjell Carlström ◽  
Åke Pousette ◽  
Rolf Blomstrand
Keyword(s):  
Protein Binding ◽  
Testosterone Level ◽  
Healthy Subjects ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Metabolic Clearance ◽  
Dehydroepiandrosterone Sulphate ◽  
Hormone Binding

Abstract. The effect of one week of controlled fasting (3 1 of fluid containing 50 g of carbohydrate/day) upon the serum levels of hormones, sex hormone binding globulin, and albumin was studied in healthy subjects. Fasting caused decreased levels of prolactin and T3, no changes in the levels of TSH, FSH, LH, dehydroepiandrosterone, 4-androstene-3,17-dione, total oestrone, and total testosterone, and increased levels of cortisol, dehydroepiandrosterone sulphate and albumin. A significant positive correlation was found between albumin and dehydroepiandrosterone sulphate. Fasting rapidly increased the levels of sex hormone binding globulin and decreased the percentage of free testosterone and the calculated free testosterone level in both sexes. A decreased metabolic clearance of certain steroids (cortisol, dehydroepiandrosterone sulphate) owing to an increased protein binding may be one of the endocrine consequences of fasting. An increased protein binding of testosterone may be outweighed by a decreased gonadal production, thus resulting in an unchanged total testosterone level. The increased sex hormone binding globulin level could not be explained by changes in gonadal and thyroid hormones.

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