Leptin and Leptin Receptor Are Expressed in the Human Endometrium and Endometrial Leptin Secretion Is Regulated by the Human Blastocyst

2000 ◽  
Vol 85 (12) ◽  
pp. 4883-4888 ◽  
Author(s):  
R. R. Gonzalez
Keyword(s):  
Leptin Receptor ◽  
Human Endometrium ◽  
Human Blastocyst

scholarly journals R-203. Expression of leptin receptor isoforms in the human endometrium

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 370-370
Author(s):  
N.D. Quinton ◽  
T.C. Li ◽  
R.J.M. Ross ◽  
E.M. Tuckerman ◽  
A.I.F. Blakemore ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Human Endometrium ◽  
Receptor Isoforms

scholarly journals P-251. Functional leptin receptor located in human endometrium

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 266-267 ◽  
Author(s):  
J. Alfer ◽  
I. Classen-Linke ◽  
W. Rath ◽  
H.M. Beier
Keyword(s):  
Leptin Receptor ◽  
Human Endometrium

scholarly journals Leptin and Leptin Receptor Are Expressed in the Human Endometrium and Endometrial Leptin Secretion Is Regulated by the Human Blastocyst1

2000 ◽  
Vol 85 (12) ◽  
pp. 4883-4888 ◽  
Author(s):  
Rubén René González ◽  
Pedro Caballero-Campo ◽  
Melinda Jasper ◽  
Amparo Mercader ◽  
Luigi Devoto ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Human Endometrium

scholarly journals Expression of Leptin Receptor in Human Endometrium and Fluctuation during the Menstrual Cycle

2000 ◽  
Vol 85 (5) ◽  
pp. 1946-1950 ◽  
Author(s):  
Jo Kitawaki ◽  
Hisato Koshiba ◽  
Hiroaki Ishihara ◽  
Izumi Kusuki ◽  
Katsumi Tsukamoto ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Splice Variants ◽  
Human Endometrium ◽  
Messenger Ribonucleic Acid ◽  
Leptin Receptors ◽  
Decidual Tissue ◽  
Long Form ◽  
Uterine Diseases ◽  
Disease Free

Abstract Leptin is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors (OB-R). Accumulated evidence shows that leptin is involved in the stimulation of reproductive functions and that local expression of leptin and OB-R in the ovary, oocyte, embryo, and placenta plays a role in early development. To investigate the role of leptin in implantation, we examined the expression of OB-R and leptin in the human endometrium. Northern and Western blot analyses and RT-PCR showed that the long form of OB-R (OB-RL) messenger ribonucleic acid (mRNA) and protein were expressed. In contrast, leptin mRNA or protein was not detected. All of the splice variants of OB-R (OB-RT) and OB-RL transcripts were expressed in 90% and 84% of the cases, respectively. OB-R mRNA expression peaked in the early secretory phase. Decidual tissue of early gestation also expressed OB-RT and OB-RL. Their incidence and abundance were comparable among endometria with benign uterine diseases and disease-free endometria and were not related to a body mass index within the normal range. The present results indicate that OB-R, but not leptin, is expressed in the human endometrium.

P 53 and p56: A new signaling pathway in human endometrium and endometrial adenocarcinomas

1997 ◽  
Vol 4 (2) ◽  
pp. 103-109
Author(s):  
G COUCHMAN ◽  
R BENTLEY ◽  
M TSAO ◽  
K RASZMANN ◽  
J MCLACHLAN ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Human Endometrium ◽  
P 53

Direct effects of hCG on the human endometrium

1998 ◽  
Vol 5 (1) ◽  
pp. 109A-109A ◽  
Author(s):  
R FANCHIN ◽  
E PELTIER ◽  
C RIGHINI ◽  
F OLIVENNES ◽  
R FRYDMAN ◽  
...  
Keyword(s):  
Human Endometrium ◽  
Direct Effects

Expression and immunohistochemical localization of leptin and leptin receptor in normal and preeclamptic placenta

1998 ◽  
Vol 5 (1) ◽  
pp. 137A-137A
Author(s):  
J MCCARTHY ◽  
D MISRA ◽  
A KANBOURSHAKIR ◽  
L MINICH ◽  
D LYKINS ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Immunohistochemical Localization
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