HUMAN FOLLICLE STIMULATING HORMONE (hFSH): FIRST PROPOSAL FOR THE AMINO ACID SEQUENCE OF THE α-SUBUNIT (hFSHα) AND FIRST DEMONSTRATION OF ITS IDENTITY WITH THE α-SUBUNIT OF HUMAN LUTEINIZING HORMONE (hLHα)

1974 ◽  
Vol 39 (1) ◽  
pp. 199-202 ◽  
Author(s):  
Basudev Shome ◽  
Albert F. Parlow
Keyword(s):  
Amino Acid ◽  
Luteinizing Hormone ◽  
Amino Acid Sequence ◽  
Follicle Stimulating Hormone ◽  
Α Subunit ◽  
Stimulating Hormone

hCG production and activity during pregnancy

2001 ◽  
Vol 12 (3) ◽  
pp. 191-208 ◽  
Author(s):  
H S Randeva ◽  
A Jackson ◽  
E Karteris ◽  
E W Hillhouse
Keyword(s):  
Luteinizing Hormone ◽  
Chorionic Gonadotropin ◽  
Essential Role ◽  
Follicle Stimulating Hormone ◽  
Thyroid Stimulating Hormone ◽  
Β Subunit ◽  
Glycoprotein Hormone ◽  
Α Subunit ◽  
Hormone Specificity ◽  
Stimulating Hormone

Human chorionic gonadotropin (hCG) has an essential role in early pregnancy. It is a member of the glycoprotein hormone family also comprising the pituitary derived follicle stimulating hormone (FSH), luteinizing hormone (LH) and thyroid stimulating hormone (TSH). Each hormone consists of a non-covalently bound α and β subunit. Within a species the α subunit is identical and hormone specificity is determined by the unique β subunit.

Short Communication: Cloning of the red kangaroo (Macropus rufus) follicle stimulating hormone beta subunit

1998 ◽  
Vol 10 (3) ◽  
pp. 289 ◽  
Author(s):  
Katherine Belov ◽  
Gavan A. Harrison ◽  
Desmond W. Cooper
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Follicle Stimulating Hormone ◽  
Hormonal Control ◽  
Beta Subunit ◽  
Brushtail Possum ◽  
Coding Region ◽  
Red Kangaroo ◽  
Antigenic Sites ◽  
Stimulating Hormone

The cDNA encoding the follicle stimulating hormone beta subunit (FSH-β) was isolated from a red kangaroo pituitary cDNA library by using a porcine probe and the nucleotide sequence for the coding region was determined. The highest degree of deduced amino acid sequence identity (91%) was observed between the red kangaroo and another marsupial, the brushtail possum (Trichosurus vulpecula), followed by eutherian species (76%, 75% and 74%, respectively, for pig, mouse and sheep). Based on the deduced red kangaroo FSH-β amino acid sequence, putative antigenic sites have been identified that may prove useful for studying the hormonal control of reproduction in marsupials.

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