Expression of Messenger Ribonucleic Acids That Encode for 3β-Hydroxysteroid Dehydrogenase and Cholesterol Side-Chain Cleavage Enzyme throughout the Luteal Phase of the Macaque Menstrual Cycle*

1991 ◽  
Vol 72 (2) ◽  
pp. 362-366 ◽  
Author(s):  
STEVEN G. BASSETT ◽  
LYNDA L. LITTLE-IHRIG ◽  
J. IAN MASON ◽  
ANTHONY J. ZELEZNIK
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Hydroxysteroid Dehydrogenase ◽  
Side Chain ◽  
Ribonucleic Acids ◽  
Side Chain Cleavage ◽  
Chain Cleavage ◽  
Cleavage Enzyme

scholarly journals Expression of 3b-Hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium

2003 ◽  
Vol 35 (3) ◽  
pp. 160-166 ◽  
Author(s):  
Hee Sub Rhee ◽  
Seon Hee Oh ◽  
Bum Joo Ko ◽  
Dong Min Han ◽  
Byung Hun Jeon ◽  
...  
Keyword(s):  
Hydroxysteroid Dehydrogenase ◽  
Side Chain ◽  
Side Chain Cleavage ◽  
Uterine Endometrium ◽  
Chain Cleavage ◽  
Cleavage Enzyme ◽  
Human Uterine Endometrium

scholarly journals Liver Receptor Homolog-1 and Steroidogenic Factor-1 Have Similar Actions on Rat Granulosa Cell Steroidogenesis

Endocrinology ◽  
2007 ◽  
Vol 148 (2) ◽  
pp. 726-734 ◽  
Author(s):  
Deeksha Saxena ◽  
Rosalba Escamilla-Hernandez ◽  
Lynda Little-Ihrig ◽  
Anthony J. Zeleznik
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cells ◽  
Hydroxysteroid Dehydrogenase ◽  
Side Chain ◽  
Steroidogenic Factor 1 ◽  
Side Chain Cleavage ◽  
Progesterone Production ◽  
Chain Cleavage ◽  
Estrogen Production ◽  
Cleavage Enzyme

Granulosa cells express the closely related orphan nuclear receptors steroidogenic factor-1 (SF-1) and liver receptor homolog-1 (LRH-1). To determine whether SF-1 and LRH-1 have differential effects on steroid production, we compared the effects of overexpressing LRH-1 and SF-1 on estrogen and progesterone production by undifferentiated rat granulosa cells. Adenovirus mediated overexpression of LRH-1 or SF-1 had qualitatively similar effects. Neither LRH-1 nor SF-1 alone stimulated estrogen or progesterone production, but when combined with FSH and testosterone, each significantly augmented progesterone production and mRNAs for cholesterol side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase above that observed with FSH alone, with SF-1 being more effective than LRH-1. LRH-1 did not augment FSH-stimulated estrogen production, whereas SF-1 produced only a slight (∼30%) augmentation of FSH-stimulated estrogen production. The stimulatory actions of both were reduced by overexpression of dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1. Expression of either LRH-1 or SF-1 together with constitutively active protein kinase B in the absence of FSH stimulated progesterone production and mRNAs for 3β-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage enzyme but did not stimulate estrogen production or mRNA for aromatase. These findings demonstrate that LRH-1 and SF-1 have qualitatively similar actions on FSH-stimulated estrogen and progesterone production, which would suggest that these factors may have overlapping actions in the regulation of steroidogenesis that accompanies granulosa cell differentiation.

P450 side-chain cleavage enzyme autoantibodies in canine Addison's disease

2013 ◽  
pp. 1-1
Author(s):  
Alisdair Boag ◽  
Kerry McLaughlin ◽  
Mike Christie ◽  
Peter Graham ◽  
Harriet Syme ◽  
...  
Keyword(s):  
Addison’S Disease ◽  
Side Chain ◽  
Addison's Disease ◽  
Side Chain Cleavage ◽  
Chain Cleavage ◽  
Cleavage Enzyme

Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme complex

1989 ◽  
Vol 998 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Sergei A. Usanov ◽  
Paavo Honkakoski ◽  
Matti A. Lang ◽  
Markku Pasanen ◽  
Olavi Pelkonen ◽  
...  
Keyword(s):  
Side Chain ◽  
Enzyme Complex ◽  
Side Chain Cleavage ◽  
Chain Cleavage ◽  
Cleavage Enzyme
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